The effect of antenatal magnesium sulphate administration on patent ductus arteriozus in very low birth weight preterms

Year 2019, Volume: 16 Issue: 2, 213 - 217, 29.08.2019

Ufuk Çakır , Cüneyt Tayman

https://doi.org/10.35440/hutfd.471717

Cited By: 1

Abstract

Background: The prevalence of patent ductus arteriosus (PDA) is inversely
proportional to gestational age and birth weight, and may lead to many
premature morbidities and mortality. There are contradictory results regarding
the fact that magnesium sulphate (MgSO4), that is used as tocolytic in
premature labor, increases the frequency of PDA. In our study, we aimed to
determine the effect of antenatal MgSO4 application on haemodynamically
significant PDA (hsPDA) in very low birth weight (VLBW; <1500g) premature infants.

Methods:
We retrospectively evaluated the medical records of VLBW preterm infants with
very low birth weight (VLBW; <1500g) between January 2013 and December
2016.The demographic and clinical characteristics of the infants were recorded.
The preterms included in the study were divided into two groups as with hsPDA
and without hsPDA. Demographic, clinical features and MgSO4 administration were
compared between two groups.

Results:
A total of 602 VLBW infans were included. 257 (42.7%) infants had hsPDA, and 11
(1.8%) infants with hsPDA had PDA ligation due to being unresponsive to medical
treatment. The rate of administration of antenatal MgSO4 in the hsPDA group was
61.8% (n = 159), and the rate of antenatal MgSO4 administration in the
non-hsPDA group was found to be statistically significant (31.6%) (n = 109) (p
<0.001).

Conclusions: In our study, the rate of antenatal MgSO4 administration and
premature morbidities were found to be higher in the hsPDA group than infants
without hsPDA.

 

Keywords:
Hemodynamically significant patent ductus arteriosus, premature, very low birth
weight, magnesium sulfate

Keywords

Hemodynamically significant patent ductus arteriosus, premature, very low birth weight, magnesium sulfate

Çok düşük doğum ağırlıklı prematürelerde antenatal magnezyum sülfat kullanımının patent duktus arteriozusa etkisi

Abstract

Amaç: Patent duktus arteriozus (PDA) sıklığı, gebelik haftası ve doğum
ağırlığıyla ters orantılıdır ve birçok prematüre morbiditesine ve mortalitesine
neden olabilir. Erken eyleminde tokolitik olarak kullanılan magnezyum sülfatın
(MgSO4) PDA sıklığını artırdığıyla ilgili çelişkili sonuçlar vardır.
Çalışmamızda çok düşük doğum ağırlıklı (ÇDDA; <1500g) prematürelerde
antenatal MgSO4 uygulanmasının hemodinamik anlamlı PDA’nın (haPDA) üzerine etkisini
belirlenmesi amaçlanmıştır.

Materyal ve
metod: Çalışmamızda Ocak 2013
ile Aralık 2016 tarihleri arasında ünitemizde izlenen, ÇDDA bebekler
retrospektif olarak incelendi. Bebeklerin demografik ve klinik özellikleri
kayıt edildi. Çalışmaya dahil edilen prematürelerin haPDA’sı olan ve olmayanlar
olarak iki gruba ayrılarak, demografik, klinik özellikleri ve MgSO4 uygulanması
açından karşılaştırıldı.

Bulgular: Toplam 602 ÇDDA bebeğin dahil edildiği çalışmamızda, 257 bebekte
(%42,7) haPDA saptandı ve 11 bebeğe (%1,8) PDA ligasyonu uygulandı. Hemodinamik
anlamlı PDA grubunda antenatal MgSO4 uygulanma oranı %61,8 (n=159), haPDA
olmayan gruptaki antenatal MgSO4 uygulanma oranına %31,6 (n=109) göre
istatistiksel olarak anlamlı yüksek olarak tespit edildi (p<0,001).

Sonuç: Çalışmamızda ÇDDA’lı bebeklerde haPDA grubunda antenatal MgSO4
kullanım oranı ve prematüre morbiditeleri daha yüksek olarak bulundu.  

 

Anahtar
kelimeler: Hemodinamik anlamlı
patent duktus arteriozus, prematüre, çok düşük doğum ağırlığı, magnezyum sülfat

Keywords

Hemodinamik anlamlı patent duktus arteriozus, prematüre, çok düşük doğum ağırlığı, magnezyum sülfat

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