Investigation of dysfunctional HDL using myeloperoxidase / paraoxonase ratio in lymphoma

Year 2019, Volume: 16 Issue: 2, 358 - 364, 29.08.2019

Salim Neşelioğlu Gültekin Pekcan Gamze Gök Emine Feyza Yurt Özcan Erel

https://doi.org/10.35440/hutfd.579011

Cited By: 2

Abstract

Background: The aim of this
study is to investigate the myeloperoxidase/paraoxonase ratio which indicates
dysfunction of high-density lipoprotein in various types of lymphoma
characterized by abnormal lipid metabolism, oxidative stress, and inflammation.

Methods: Thirty lymphoma
patients and 30 healthy subjects were enrolled in this study. Serum
myeloperoxidase, paraoxonase, arylesterase, lipid hydroperoxide and routine
biochemistry tests levels were measured on an automated analyzer. The diagnosis
of lymphoma patients was made according to the histological examination of the
biopsy material.

Results: Compared with
healthy control group; the albumin, arylesterase, high-density lipoprotein,
thiol, and Hemoglobin levels were significantly lower while myeloperoxidase /
paraoxonase, myeloperoxidase/arylesterase, and lipid hydroperoxide levels were
significantly higher, in patients with lymphoma. Also, lipid hydroperoxide
level was significantly correlated with myeloperoxidase / paraoxonase and
myeloperoxidase / arylesterase (r= 0.330, p=0.046; r=
0.588, p< 0.001, respectively).

Conclusions: We think that
dysfunctional high-density lipoprotein is an important factor in the
inflammatory process, atherosclerosis, oxidative stress, and impaired lipid
metabolism that can be observed in patients with lymphoma. We believe that in
the future the myeloperoxidase/paraoxonase ratio can be used as a treatment
criterion to prevent diseases that cause dysfunctional high-density
lipoprotein.

Keywords

Arylesterase, Dysfunctional HDL, Lipd hydroperoxide, Myeloperoxidase/paraoxonase ratio, Paraoxonase

Lenfomada miyeloperoksidaz/paraoksonaz oranı kullanılarak disfonksiyonel HDL’nin araştırılması

Abstract

Amaç: Bu çalışmanın amacı, anormal lipid metabolizması, oksidatif stres ve
inflamasyon ile karakterize çeşitli lenfoma tiplerinde disfonksiyonel HDL'yi
gösteren miyeloperoksidaz / paraoksonaz oranını araştırmaktır.

Materyal ve Metot: Çalışmaya 30 lenfoma hastası ve 30 sağlıklı birey alındı. Otomatik
analizörde serum myeloperoksidaz, paraoksonaz, arilesteraz, lipid hidroperoksit
parametrelerinin ve rutin biyokimya testlerinin düzeyleri ölçüldü. Lenfoma
hastalarının tanısı biyopsi materyalinin histolojik incelemesine göre konuldu.

Bulgular: Sağlıklı kontrol grubu ile karşılaştırıldığında; albumin, arilesteraz,
HDL, tiyol ve Hemoglobin seviyeleri anlamlı derecede düşükken, myeloperoksidaz
/ paraoksonaz oranı, myeloperoksidaz / arilesteraz oranı ve lipid hidroperoksit
seviyeleri, lenfomalı hastalarda anlamlı olarak daha yüksekti. Ayrıca lipid
hidroperoksit düzeyi, miyeloperoksidaz / paraoksonaz oranı ve miyeloperoksidaz
/ paraoksonaz oranı ile anlamlı şekilde ilişkiliydi (sırasıyla r= 0.330, p=0.046; r=
0.588, p< 0.001)

Sonuç: Biz disfonksiyonel HDL'nin, lenfoma hastalarında gözlenen inflamatuar
süreç, ateroskleroz, oksidatif stres ve bozulmuş lipid metabolizmasında önemli
bir faktör olduğunu düşünüyoruz. Gelecekte myeloperoxidase / paraoxonase
oranının, disfonksiyonel HDL'ye sebep olan hastalıkları önlemek için bir tedavi
kriteri olarak kullanılabileceğine inanıyoruz.

Keywords

Arilesteraz, Disfonksiyonel HDL, Lipit hidroperoksit, Myeloperoksidaz/paraoksonaz oranı, Paraoksonaz

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