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Laküner infarkt ve anjiotensin dönüştürücü enzim gen polimorfizmi arasındaki ilişki English

Year 2013, Volume: 10 Issue: 3, 131 - 136, 01.12.2013

Abstract

Amaç: Serebral laküner infarktlar ile anjiyotensin dönüştürücü enzim ADE gen polimorfizmi arası ilişkiyi araştırmak.Materyal ve metot: Çalışmaya bilgisayarlı tomografisinde laküner infarkt tespit edilen 23 hasta ile bilgisayarlı tomografisi normal olan 26 kontrol dahil edildi. Risk faktörleri olarak yaş, cinsiyet, hipertansiyon, diyabet, kalp hastalığı, hiperlipidemi ve sigara içimi alındı. Polimerize zincir reaksiyonu kullanılarak ADE geninde insersiyon delesyonlar araştırıldı.Bulgular: Laküner infarkt grubunda ortalama hiperlipidemi insidansı ve ortalama yaş kontrol grubundan daha yüksek bulundu p

References

  • ) Markus HS, Barley J, Lunt R, Bland MJ, Jeffery S, Carter ND, et al. Angiotensin converting enzyme gene deletion polymorpism.A new risk factor for lacunar stroke but not carotid atheroma. Stroke 1995; 26(8): 33.
  • ) Hassan A, Markus HS. Genetics and ischaemic stroke. Brain 2000; 123(9): 1784-812.
  • ) Kario K, Kanai N, Saito K, Nagon N, Matsuo T, Shimada K. Ischaemic stroke and the gene for angiotensin converting enzyme in Japanese hypertensives. Circulation 1996; 93(9): 1630-33.
  • ) Rigat B, Hubert C, Alhene-Gelas F, Cambien F, Corvol P,Soubrier F. An insertion/deletion polymorhism in the angiotensin converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990; 86(4): 1343-46.
  • ) Agerholm-Larsen B, Tybaerg-Hansen A, Frikke- Schmidt R, Gronholdt MLM, Jensen G, Nordestaard BG. ACE gene polymorphism as a risk factor for ischaemic cerebrovascular disease. Ann Intern Med. ; 127(5): 346-55. ) Hassan A, Lansburry A, Catto AT, Guthrie A, Spencer J, Craven C, et al. Angiotensin converting enzyme insertion/deletion genotype is associated with leukoaraiosis in lacunar syndromes. J Neurol Neurosurg Psychiatry. 2002; 72(3): 343-46.
  • ) Rigat B, Hubert C, Corvol P, Soubrier F. PCR detection of insertion/deletion polymorphism of the human angiotensın converting enzyme gene (dcp1) (dipeptidyl carboxypeptidase 1). Nucleic Acids Res 1992; 20(6)
  • ) Horowitz DR, Tuhrim S, Weinberger JM, Rudolf SH. Mechanisms in lacunar infarction. Stroke 1992; 23(3): 27.
  • ) Munshi A, Sultana S, Kaul S, Reddy BP, Alladi S, J y o t h y A . A n g i o t e n s i n - c o n v e r t i n g e n z y m e insertion/deletion polymorphism and the risk of ischemic stroke in a south ındian population. J Neurol Sci. 2008; (1-2): 132-5.
  • ) Saidi S, Zammiti W, Slamia LB, Ammou SB, Almawi WY, Mahjoub T. Interaction of angiotensin-converting enzyme and apolipoprotein E gene polymorphisms in ischemic stroke involving large-vessel disease. J Thromb Thrombolysis 2009; 27(1): 68-74.
  • ) Li CM, Zhang C, Lu XL, Feng HY, Su QX, Zeng Y, et al. Relationship between angiotensin converting enzyme gene and ischemic stroke. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue.2007; 19(6): 321-4.
  • ) Kostulas K, Huang WX, Crisby M,Jin YP, He B, Lannfelt L et al. An angiotensin-converting enzyme gene polymorphism suggests a genetic distinction between ischaemic stroke and carotid stenosis. Eur J Clin Invest.1999; 29(6): 478-83.
  • ) Pullicino P, Kwen PL, Greenberg S, Becker AL, Glenister N. Angiotensin converting enzyme gene and lacunar stroke. Stroke 1996; 27(3): 569-70.
  • ) Seino Y, Ikeda U, Maeda Y, Haga Y, Yashima H, Shimada K. Angiotensin converting enzyme gene polymorphism and plasminogen activator inhibitor I levels in subjects with cerebral infarction. Journal of Thrombosis and Thrombolysis 1998; 5(3): 263-67.
  • ) Sharma P. Meta-analysis of the ace gene in ischaemic stroke. J neurol neurosurg psychiatry 1998; (2): 227-30.
  • ) Szolnoki Z, Somogyvari F, Kondacs A, Szabo M, Fodor L. Evaluation of the roles of the Leiden V mutation and ACE I/D polymorphism in subtypes of ıschaemic stroke. J Neurol. 2001; 248(9): 756-61.
  • ) Pera J, Slowik A, Dziedzic T, Wloch D, Szczudlik A. ACE I/D polymorphism in different etiologies of ischemic stroke. Acta Neurol Scand. 2006; 114(5): 320
  • ) Celiker G, Can U, Verdi H, Yazici AC, Ozbek N, Atac FB. Prevalence of thrombophilic mutations and ACE I/D polymorphism in Turkish ischemic stroke patients. Clin Appl Thromb Hemost. 2009; 15(4): 415-20.
  • ) Tuncer N, Tuglular S, Kiliç G, Sazci A, Us O, Kara I. Evaluation of the angiotensin-converting enzyme insertion/deletion plymorhism and the risk of ischaemic stroke. J Clin Neuroscience 2006; 13(2): 224-7.

The relationship between angiotensin converting enzyme gene polimorphism and lacunar infarction

Year 2013, Volume: 10 Issue: 3, 131 - 136, 01.12.2013

Abstract

Background: To evaluate the relationship between polymorphisms of the angiotensin converting enzyme ACE gene and cerebral lacunar infarction.Methods: We included 23 patients with cerebral lacunar infarct confirmed with computerized tomography CT , and 26 controls with normal CT scans. We considered age, sex, hypertension, diabetes mellitus, cardiac disease, hyperlipidemia and smoking as risk factors. Insertions or deletions I/D in the ACE gene were detected using polymerase chain reaction PCR .Results: The average incidence of hyperlipidemia and mean age were higher in the lacunar infarct group p

References

  • ) Markus HS, Barley J, Lunt R, Bland MJ, Jeffery S, Carter ND, et al. Angiotensin converting enzyme gene deletion polymorpism.A new risk factor for lacunar stroke but not carotid atheroma. Stroke 1995; 26(8): 33.
  • ) Hassan A, Markus HS. Genetics and ischaemic stroke. Brain 2000; 123(9): 1784-812.
  • ) Kario K, Kanai N, Saito K, Nagon N, Matsuo T, Shimada K. Ischaemic stroke and the gene for angiotensin converting enzyme in Japanese hypertensives. Circulation 1996; 93(9): 1630-33.
  • ) Rigat B, Hubert C, Alhene-Gelas F, Cambien F, Corvol P,Soubrier F. An insertion/deletion polymorhism in the angiotensin converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990; 86(4): 1343-46.
  • ) Agerholm-Larsen B, Tybaerg-Hansen A, Frikke- Schmidt R, Gronholdt MLM, Jensen G, Nordestaard BG. ACE gene polymorphism as a risk factor for ischaemic cerebrovascular disease. Ann Intern Med. ; 127(5): 346-55. ) Hassan A, Lansburry A, Catto AT, Guthrie A, Spencer J, Craven C, et al. Angiotensin converting enzyme insertion/deletion genotype is associated with leukoaraiosis in lacunar syndromes. J Neurol Neurosurg Psychiatry. 2002; 72(3): 343-46.
  • ) Rigat B, Hubert C, Corvol P, Soubrier F. PCR detection of insertion/deletion polymorphism of the human angiotensın converting enzyme gene (dcp1) (dipeptidyl carboxypeptidase 1). Nucleic Acids Res 1992; 20(6)
  • ) Horowitz DR, Tuhrim S, Weinberger JM, Rudolf SH. Mechanisms in lacunar infarction. Stroke 1992; 23(3): 27.
  • ) Munshi A, Sultana S, Kaul S, Reddy BP, Alladi S, J y o t h y A . A n g i o t e n s i n - c o n v e r t i n g e n z y m e insertion/deletion polymorphism and the risk of ischemic stroke in a south ındian population. J Neurol Sci. 2008; (1-2): 132-5.
  • ) Saidi S, Zammiti W, Slamia LB, Ammou SB, Almawi WY, Mahjoub T. Interaction of angiotensin-converting enzyme and apolipoprotein E gene polymorphisms in ischemic stroke involving large-vessel disease. J Thromb Thrombolysis 2009; 27(1): 68-74.
  • ) Li CM, Zhang C, Lu XL, Feng HY, Su QX, Zeng Y, et al. Relationship between angiotensin converting enzyme gene and ischemic stroke. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue.2007; 19(6): 321-4.
  • ) Kostulas K, Huang WX, Crisby M,Jin YP, He B, Lannfelt L et al. An angiotensin-converting enzyme gene polymorphism suggests a genetic distinction between ischaemic stroke and carotid stenosis. Eur J Clin Invest.1999; 29(6): 478-83.
  • ) Pullicino P, Kwen PL, Greenberg S, Becker AL, Glenister N. Angiotensin converting enzyme gene and lacunar stroke. Stroke 1996; 27(3): 569-70.
  • ) Seino Y, Ikeda U, Maeda Y, Haga Y, Yashima H, Shimada K. Angiotensin converting enzyme gene polymorphism and plasminogen activator inhibitor I levels in subjects with cerebral infarction. Journal of Thrombosis and Thrombolysis 1998; 5(3): 263-67.
  • ) Sharma P. Meta-analysis of the ace gene in ischaemic stroke. J neurol neurosurg psychiatry 1998; (2): 227-30.
  • ) Szolnoki Z, Somogyvari F, Kondacs A, Szabo M, Fodor L. Evaluation of the roles of the Leiden V mutation and ACE I/D polymorphism in subtypes of ıschaemic stroke. J Neurol. 2001; 248(9): 756-61.
  • ) Pera J, Slowik A, Dziedzic T, Wloch D, Szczudlik A. ACE I/D polymorphism in different etiologies of ischemic stroke. Acta Neurol Scand. 2006; 114(5): 320
  • ) Celiker G, Can U, Verdi H, Yazici AC, Ozbek N, Atac FB. Prevalence of thrombophilic mutations and ACE I/D polymorphism in Turkish ischemic stroke patients. Clin Appl Thromb Hemost. 2009; 15(4): 415-20.
  • ) Tuncer N, Tuglular S, Kiliç G, Sazci A, Us O, Kara I. Evaluation of the angiotensin-converting enzyme insertion/deletion plymorhism and the risk of ischaemic stroke. J Clin Neuroscience 2006; 13(2): 224-7.
There are 18 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Handan Akar This is me

Nilgün Cengiz This is me

Abdülkerim Bedir This is me

Musa Kazım Onar This is me

Publication Date December 1, 2013
Published in Issue Year 2013 Volume: 10 Issue: 3

Cite

Vancouver Akar H, Cengiz N, Bedir A, Onar MK. The relationship between angiotensin converting enzyme gene polimorphism and lacunar infarction. Harran Üniversitesi Tıp Fakültesi Dergisi. 2013;10(3):131-6.

Harran Üniversitesi Tıp Fakültesi Dergisi  / Journal of Harran University Medical Faculty