Romatizmal mitral darlığında fetuin-A düzeyleri ve ekokardiyografi bulguları ile ilişkisi Türkçe

Ahmet Çelik; Hatice Sezen; Yusuf Sezen; Elif Şahin; Sefa Çiftçi; Metin Kılınç

Romatizmal mitral darlığında fetuin-A düzeyleri ve ekokardiyografi bulguları ile ilişkisi Türkçe

Year 2013, Volume: 10 Issue: 3, 124 - 130, 01.12.2013

Ahmet Çelik Hatice Sezen Yusuf Sezen Elif Şahin Sefa Çiftçi Metin Kılınç

Abstract

Amaç: Fetuin-A, dolaşımda bulunan, distrofik vasküler ve valvüler kalsifikasyon oluşumunu önleyen bir akut faz proteinidir. Bu çalışmanın amacı, Romatizmal Mitral Darlığı olan hastalarda serum fetuin-A düzeylerinin sağlıklı kişilere göre ne yönde değiştiğini ve ekokardiyografi bulguları ile ilişkili olup olmadığını belirlemektir.Materyal ve metod: Tanısı Ekokardiyografi ile konmuş, Romatizmal Mitral Darlığı olan elli hasta ve yaş ve cinsiyet karşılaştırmalı elli iki sağlıklı kişi çalışmaya dahil edildi. Her bireyin serum Fetuin-A düzeyi ELISA metodu ile ölçüldü.Bulgular: Hastalar ile kontrol grubu arasında serum Fetuin-A düzeyleri yönünden anlamlı fark yoktu sırasıyla 29,35±6,41 ng/mL ve 27,64±6,35 ng/mL; p=0,262 . Hastalarda Ekokardiyografi ile belirlenen Wilkins kalsifikasyon skoru ile serum Fetuin-A düzeyleri arasında anlamlı korelasyon bulunmadı.Sonuç: Hastaların kullanmakta oldukları antimikrobiyal ve antiinflamatuar ilaçların etkisiyle serum FetuinA düzeylerinin düşmesi önlenmiş olabilir. İki boyutlu Ekokardiyografi ile değerlendirildiğinde Mitral kapaktaki kalsifikasyonun derecesi ile serum fetuin-A düzeyi arasında anlamlı bir ilişki bulunmamıştır

Keywords

Fetuin-A, romatizmal kalp kastalığı, ekokardiyografi

References

) Arnaud P, Kalabay L. Alpha2-HS glycoprotein: a protein in search of a function. Diabetes Metab Res Rev. ; 18(4): 311-4. ) Ketteler M, Bongartz P, Westenfeld R, et al. J. Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study. Lancet. 2003; (9360): 827-33.
) Reynolds JL, Skepper JN, McNair R, et al. Multifunctional roles for serum protein fetuin-a in inhibition of human vascular smooth muscle cell calcification. J Am Soc Nephrol. 2005; 16 (10): 2920-30.
) Schafer C, Heiss A, Schwarz A, et al. The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin- A is a systemically acting inhibitor of ectopic calcification. J Clin Invest. 2003; 112(3): 357-66.
) Carapetis JR, Steer AC, Mulholland EK, Weber M. (et al). The global burden of group A streptococcal diseases. Lancet Infect Dis. 2005; 5(11): 685-94.
) Pedrazzini GB, Faletra F, Vassalli G, et al. Mitral regurgitation. Swiss Med Wkly. 2010; 140(3-4): 36-43.
) Chandrashekhar Y, Westaby S, Narula J. Mitral stenosis. Lancet. 2009; 374: 1271-83.
) Schiller NB, Shah PM, Crawford M, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr. 1989; 2: 358
) Ali SK, Eldaim IN, Osman SH, et al. Clinical and echocardiographic features of children with rheumatic heart disease and their serum cytokine profile. Pan Afr Med J. 2012; 13: 36.
) Davutoglu V, Celik A, Aksoy M. Contribution of selected serum inflammatory mediators to the progression of chronic rheumatic valve disease, subsequent valve calcification and NYHA functional class. J Heart Valve Dis. 2005; 14(2): 251-6.
) Wilkins GT, Weyman AE, Abascal VM, et al. Percutaneous balloon dilatation of the mitral valve: an analysis of echocardiographic variables related to outcome and the mechanism of dilatation. Br Heart J. ; 60(4): 299. ) Price PA, Lim JE. The inhibition of calcium phosphate precipitation by fetuin is accompanied by the formation of a fetuin-mineral complex. J Biol Chem. 2003; 278(24): 52.
) Cagli K, Basar N, Cagli K, et al. Association of serum fetuin-A with valvular calcium concentration in rheumatic mitral valve disease. J Heart Valve Dis. 2010; 19(5): 636
) Afsar CU, Uzun H, Yurdakul S, et al. Association of serum fetuin-A levels with heart valve calcification and other biomarkers of inflammation among persons with acute coronary syndrome. Clin Invest Med. 2012; 35(4): 15.
) Ix JH, Chertow GM, Shlipak MG, et al. Association of fetuin-A with mitral annular calcification and aortic stenosis among persons with coronary heart disease: data from the Heart and Soul Study. Circulation. 2007; 115(19): 9.
) Kaden JJ, Reinöhl JO, Blesch B, et al. Systemic and local levels of fetuin-A in calcific aortic valve stenosis. Int J Mol Med. 2007; 20(2): 193-7.
) Wang AY, Woo J, Lam CW, et al. Associations of serum fetuin-A with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients. Nephrol Dial Transplant. 2005; 20(8): 1676-85.
) El-Shehaby AM, Zakaria A, El-Khatib M, et al. Association of fetuin-A and cardiac calcification and inflammation levels in hemodialysis patients. Scand J Clin Lab Invest. 2010; 70(8): 575-82.
) Adamczyk T, Mizia-Stec K, Mizia M, et al. Biomarkers of calcification and atherosclerosis in patients with degenerative aortic stenosis in relation to concomitant coronary artery disease. Pol Arch Med Wewn. 2012; 122(1-2): 14-21.

Fetuin-A levels in rheumatismal mitral stenosis and its relationship with echocardiographic findings

Year 2013, Volume: 10 Issue: 3, 124 - 130, 01.12.2013

Ahmet Çelik Hatice Sezen Yusuf Sezen Elif Şahin Sefa Çiftçi Metin Kılınç

Abstract

Background: Fetuin-A is an acute phase protein that exists in circulation and prevents the formation of dystrophic vascular and valvular calcification. The aim of this study was to determine how serum fetuin-A levels changed in Rheumatic Mitral Stenosis patients when compared to healthy control subjects and whether it was associated with echocardiographical data.Methods: Fifty Rheumatic Mitral Stenosis patients diagnosed by echocardiography and age-sex matched fifty-two control subjects were included into the study. Serum fetuin-A level of each subject was measured by ELISA method.Results: There was no significant difference between patients and controls in serum fetuin-A levels respectively 27,64±6,35 ng/mL and 29,35±6,41 ng/mL; p=0,262 . In additon, no significant correlation was found between Wilkins calcification score determined by echocardiography and serum fetuin-A levels in patients.Conclusions: Decrease of serum fetuin-A levels might have been inhibited due to the usage of antimicrobial and antiinflammatory drugs of patients. A significant relationship wasn't found when serum fetuin-A levels and calcification in the mitral valve determined by ecocardiographic data were correlated in these patients

Keywords

Fetuin-A, rheumatismal heart disease, echocardiography

References

) Arnaud P, Kalabay L. Alpha2-HS glycoprotein: a protein in search of a function. Diabetes Metab Res Rev. ; 18(4): 311-4. ) Ketteler M, Bongartz P, Westenfeld R, et al. J. Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study. Lancet. 2003; (9360): 827-33.
) Reynolds JL, Skepper JN, McNair R, et al. Multifunctional roles for serum protein fetuin-a in inhibition of human vascular smooth muscle cell calcification. J Am Soc Nephrol. 2005; 16 (10): 2920-30.
) Schafer C, Heiss A, Schwarz A, et al. The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin- A is a systemically acting inhibitor of ectopic calcification. J Clin Invest. 2003; 112(3): 357-66.
) Carapetis JR, Steer AC, Mulholland EK, Weber M. (et al). The global burden of group A streptococcal diseases. Lancet Infect Dis. 2005; 5(11): 685-94.
) Pedrazzini GB, Faletra F, Vassalli G, et al. Mitral regurgitation. Swiss Med Wkly. 2010; 140(3-4): 36-43.
) Chandrashekhar Y, Westaby S, Narula J. Mitral stenosis. Lancet. 2009; 374: 1271-83.
) Schiller NB, Shah PM, Crawford M, et al. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms. J Am Soc Echocardiogr. 1989; 2: 358
) Ali SK, Eldaim IN, Osman SH, et al. Clinical and echocardiographic features of children with rheumatic heart disease and their serum cytokine profile. Pan Afr Med J. 2012; 13: 36.
) Davutoglu V, Celik A, Aksoy M. Contribution of selected serum inflammatory mediators to the progression of chronic rheumatic valve disease, subsequent valve calcification and NYHA functional class. J Heart Valve Dis. 2005; 14(2): 251-6.
) Wilkins GT, Weyman AE, Abascal VM, et al. Percutaneous balloon dilatation of the mitral valve: an analysis of echocardiographic variables related to outcome and the mechanism of dilatation. Br Heart J. ; 60(4): 299. ) Price PA, Lim JE. The inhibition of calcium phosphate precipitation by fetuin is accompanied by the formation of a fetuin-mineral complex. J Biol Chem. 2003; 278(24): 52.
) Cagli K, Basar N, Cagli K, et al. Association of serum fetuin-A with valvular calcium concentration in rheumatic mitral valve disease. J Heart Valve Dis. 2010; 19(5): 636
) Afsar CU, Uzun H, Yurdakul S, et al. Association of serum fetuin-A levels with heart valve calcification and other biomarkers of inflammation among persons with acute coronary syndrome. Clin Invest Med. 2012; 35(4): 15.
) Ix JH, Chertow GM, Shlipak MG, et al. Association of fetuin-A with mitral annular calcification and aortic stenosis among persons with coronary heart disease: data from the Heart and Soul Study. Circulation. 2007; 115(19): 9.
) Kaden JJ, Reinöhl JO, Blesch B, et al. Systemic and local levels of fetuin-A in calcific aortic valve stenosis. Int J Mol Med. 2007; 20(2): 193-7.
) Wang AY, Woo J, Lam CW, et al. Associations of serum fetuin-A with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients. Nephrol Dial Transplant. 2005; 20(8): 1676-85.
) El-Shehaby AM, Zakaria A, El-Khatib M, et al. Association of fetuin-A and cardiac calcification and inflammation levels in hemodialysis patients. Scand J Clin Lab Invest. 2010; 70(8): 575-82.
) Adamczyk T, Mizia-Stec K, Mizia M, et al. Biomarkers of calcification and atherosclerosis in patients with degenerative aortic stenosis in relation to concomitant coronary artery disease. Pol Arch Med Wewn. 2012; 122(1-2): 14-21.

There are 17 citations in total.

Details

Primary Language	Turkish
Journal Section	Research Article
Authors	Ahmet Çelik Hatice Sezen This is me Yusuf Sezen This is me Elif Şahin This is me Sefa Çiftçi This is me Metin Kılınç This is me
Publication Date	December 1, 2013
Published in Issue	Year 2013 Volume: 10 Issue: 3

Cite

Vancouver	Çelik A, Sezen H, Sezen Y, Şahin E, Çiftçi S, Kılınç M. Romatizmal mitral darlığında fetuin-A düzeyleri ve ekokardiyografi bulguları ile ilişkisi Türkçe. Harran Üniversitesi Tıp Fakültesi Dergisi. 2013;10(3):124-30.