Pulmoner arter basıncının serum seruloplazmin düzeyi ile ilişkisi Türkçe

Year 2012, Volume: 9 Issue: 3, 104 - 111, 01.12.2012

Zekeriya Kaya Atilla Esmer Ramazan Asoğlu Ali Yıldız Turgay Ulaş Hatice Sezen Mehmet Salih Aydın Abdullah Taşkın Nurten Aksoy

Abstract

Amaç: Pulmoner arter basıncı yüksekliği PAB etiyolojisinde pek çok faktörün olduğu kompleks bir hastalıktır. Demir metabolizmasında, bakır taşınmasında görevleri olan, aynı zamanda antioksidan ve akut faz reaktanı bir enzim olan seruloplazminin Cp pulmoner arteryel hipertansiyon PAH hastalarında düzeyleri bilinmemektedir. Bu çalışma PAB ile serum Cp düzeyinin ilişkisini araştırmak üzere planlandı.Materyal ve metod: Çalışmaya kardiyoloji ekokardiyografi laboratuarına başvuran ve PAB ölçülen 100 ardışık olgu alındı. Altta yatan nedene bakılmaksızın sistolik PAB 40 mm Hg ve üstündeki 50 hasta ise PAH grubu olarak; 40 mmHg altında olan 50 hasta kontrol grubu olarak ayrıldı. Tüm olgularda serum Cp düzeyi spektrofotometrik olarak bakıldı. Bulgular: PAH grubunda serum Cp düzeyi kontrollere göre yüksekti 668,1±107,4 μg/dL'e karşılık 623,3±101,1 μg/dL; p=0,012 . Pearson korelâsyon analizinde serum Cp düzeyi ile PAB, açlık kan şekeri ve hemoglobin düzeyi arasındaki ilişki anlamlı iken p=0,003 lineer regresyon analizinde bağımsız ilişki izlenmedi p=0,068 . Sonuç: PAH'da serum Cp artışı, bu enzimin akut faz reaktanı, hipoksi tarafından indüklenebilir bir enzim olması, PAH sırasında artan bazı oksidanlar tarafından oksidatif modifikasyona uğrayarak oksidan gibi davranması ile ilişkili olabileceğini düşündürmektedir

Keywords

Pulmoner hipertansiyon, seruloplazmin

The relationship between pulmonary artery pressure and ceruloplasmin levels

Abstract

Background: Increased pulmonary artery pressure PAP is a complex disease and unknown etiology. Ceruloplasmin Cp is a plasma protein associated with iron metabolism and copper transport, an antioxidant and an acute phase reactant. Cp levels are not known in pulmonary arterial hypertension PAH . This study was designed to investigate the relationship between PAP and serum Cp levels.Methods: One hundred consecutive patients, who admitted to cardiology echocardiography laboratory and PAP pressure can be measured, were included in this study. Regardless of the underlying cause, PAH group 50 patient with systolic PAP 40 mm Hg and above, and control group 50 patient with PAP less than 40 mmHg. In all cases, serum Cp levels were determined spectrophotometrically.Results: Serum Cp levels 668.1 ± 107.4 μg/dL vs. 623.3 ± 101.1 μg/dL, p = 0.012 were higher in PAH group than in controls. Pearson's correlation analysis showed a significant relationship among serum Cp levels, fasting blood glucose and hemoglobin level p=0,003 . With linear regression analysis, only independent relationship among serum Cp, the level of fasting blood glucose and hemoglobin p = 0.068 .Conclusions: Increased Cp in patient PAH might be related to features of acute phase reactant of this enzyme, inducible by hypoxia, act as oxidant with undergoes oxidative modification by some increased oxidants in PAH

Keywords

Pulmonary hypertension, ceruloplasmin

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