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Deneysel Üçlü Subaraknoid Kanama Modelinde Resveratrolün Vazospazm Üzerine Etkisi

Year 2008, Volume: 5 Issue: 3, 9 - 15, 01.12.2008

Abstract

Amaç Anevrizmal subaraknoid kanamayı takiben gelişen serebral vazospazmın mortalite ve morbidite üzerinde önemli etkileri vardır. Yapılmış olan pek çok çalışmaya rağmen serebral vazospazmın kesin nedeni ve etiyolojisi bilinmemektedir ve uygun bir tedavi yöntemi de henüz belirlenmemiştir. Bu çalışmada resveratrolün üçlü subaraknoid kanama SAK modeli ile tavşan baziler arterinde oluşturulan akut serebral vazospazm üzerine etkisi anjiyografik olarak incelenmiştir Gereç ve yöntem Bu çalşımada 6 grup Yeni Zelanda tavşanında deneysel olarak oluşturulan üçlü subaraknoid kanama modelinde resveratrol ve çözücüsü dimetil sülfoksitin baziler arterdeki vazospazm üzerine etkisi anjiyografi ile değerlendirilmiştir. Her grupta 8 tavşan bulunuyordu ve toplam 48 tavşan çalışmaya dahil edildi. Bulgular SAK - tavşanlarda 3. Grup resveratrol öncesi ve sonrası ölçümler arasında istatistiksel olarak bir fark yoktu p>0.05 . tedavi için resveratrolün kullanıldığı SAK + grupta 6. Grup 15. Dakika ve 72. Saatte elde edilen baziler arter çapları karşılaştırıldığında anlamlı bir düzelme olduğu görüldü p

References

  • Heros RC, Zervas NT, Varsos V. Cerebral vasospasm after subarachnoid hemorrhage: an update. Ann Neurol, 1983; 14: 599-608.
  • Cook DA. Mechanisms of cerebral vasospasm in subarachnoid hemorrhage. Pharmacol Ther, 1995; 66: 259-284.
  • Bell TE, Kongable GL. Innovations in aneurysmal intracisternal t-PA for the prevention of vasospasm. J Neurosci Nurs, 1996; 28: 107- 113.
  • hemorrhage: 4. Miburn JM, Moran CJ, Cross DT. Increase in diameters of vasospastic intracranial arteries by intraarterial papaverine administration. J Neurosurg, 1998; 88: 38-42.
  • Elmali N, Esenkaya I, Harma A, et al. Effect of resveratrol in experimental osteoarthritis in rabbits. Inflamm Res, 2005; 54: 158–162. 6.
  • Goldberg D, Tsang E, Karuanchiri A, et al. Method to assay the concentrations of phenolic constituents of biological interest in wines. Anal Chem, 1996; 68: 1688–1694.
  • Das S, Alagappan VK, Bagchi D, et al. Coordinated induction of iNOS-VEGF-KDR- eNOS after resveratrol consumption: a potential preconditioning
  • Pharmacol, 2005; 42: 281-289. resveratrol the heart. Vascul 8. Bhat KPL, Kosmeder JW, Pezzuto JM. Biological
  • Antioxid Redox Signal, 2001; 3:1041–1064. of resveratrol. 9. Kimura Y. New anticancer agents: in vitro and in vivo evaluation of the antitumor and antimetastatic actions of various compounds isolated from medicinal plants. In Vivo, 2005;19: 37-60.
  • Dobrydneva Y, Williams RL, Blackmore PF. Trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br J Pharmacol, 1999; 128:149–157.
  • Sancak T, Silav G, Egemen N, Aldur M. Subarachnoid heamorrhage-induced chronic cerebral vasospasm in the rabbit: IV-DSA versus IA-DSA.Acta Neurochir (Wien) 2002; 144: 929-931.
  • Wang Q, Xu J, Rottinghaus GE, et al. Resveratrol protects against global cerebral ischemic injury in gerbils. Brain Res, 2002; 958: 439–447.
  • Sinha K, Chaudhary G, Gupta YK. Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats. Life Sci, 2002; 71: 655–665.
  • Kassel NF, Peerless SJ, Durward QJ. Treatment vasospasm expansion and induced arterial hypertension. Neurosurg, 1982; 11: 337-343.
  • Yano K, Kuroda T, Tanabe Y. Preventive therapy against delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: trials of thromboxane A2 synthetase inhibitor and hyperdynamic therapy. Acta Neurochir (Wien), 1993; 125: 15-19.
  • Feigin VL, Rinkel GJE, Algra A. Calcium antagonists in patients with aneurysmal subarachnoid hemorrhage. Neurology, 1998; 50: 876-882.
  • Haley EC Jr, Kassel NF, Torner JC. A randomized controlled trial of high dose intravenous
  • subarachnoid hemorrhage: a report of the cooperative aneurysm study. J Neurosurg, 1993; 78: 537-547. in
  • aneurysmal 18. Fandino J, Kaku Y, Schuknecht B. Improvement of cerebral oxygenation patterns and metabolic validation of super selective intraarterial infusion of papaverine for the treatment of cerebral vasospasm. J Neurosurg, 1998; 89: 93-100.
  • Polin RS, Hansen CA, German P. Intra- arterially administered papaverine treatment of Neurosurg, 1997; 42: 1256-1267.
  • vasospasm. 20. Shiokawa K, Kasuya H, Miyajima M, Izawa M, Takakura K. Prophylactic effect of papaverine
  • cerebral vasospasm in dogs. Neurosurg, 1998; 42: 109-116. pellets on 21. Alabadi JA, Torregrosa G, Miranda FJ, et al. Impairment of the modulatory role of nitric oxide on the endothelin-1-elicited contraction of cerebral arteries: a pathogenetic factor in cerebral hemorrhage. Neurosurg, 1997; 41: 245-252.
  • Pluta RM, Oldfield EH, Boock RJ. Reversal and prevention of cerebral vasospasm by intracarotid infusions of nitric oxide donors in a primate model of subarachnoid hemorrhage. J Neurosurg, 1997; 87: 746-751.
  • Kwan AL, Bavbek M, Jeng AY, et al. Prevention and reversal of cerebral vasospasm by an endothelin-converting enzyme inhibitor, CGS 26303, in an experimental model of subarachnoid hemorrhage. J Neurosurg, 1997; 87: 281-286.
  • Kwan AL, Lin CL, Yanamoto H, et al. Systemic administration of the potassium channel activator cromakalim attenuates cerebral
  • subarachnoid hemorrhage. Neurosurg, 1998; 42: 347-350. after experimental The effect of intrathecal sodium nitroprusside on severe chronic vasospasm. Neurol Res, 1993; 15: 310–315.
  • Chyatte D, Fode NC, Nichols DA, Sundt TM Jr. Preliminary report: effects of high dose methylprednisolone on delayed cerebral ischemia in patients at high risk for vasospasm after aneurysmal subarachnoid hemorrhage. Neurosurg, 1987; 21: 157-160.
  • Bagdatoglu C, Guleryuz A, et al. Resolution of cerebral vasospasm with trapidil; an animal model. J Clin Neurosci, 2002; 9: 429–432.
  • Egemen N, Baskaya MK, Turker RK, et al. Protection by iloprost (stable analogue of prostacyclin) of endothelial damage due to chronic vasospasm in dogs: an electron microscope study. Neurol Res, 1995; 17: 301- 306.
  • Egemen N, Turker RK, Sanlidilek U. The effect of iloprost on chronic cerebral vasospasm. Gen Pharmac, 1993; 24: 403-409. 30. Ergun H, Bagdatoglu C, Ugur H, et al. Vasorelaxant
  • experimental vasospasm model in rabbits. Neurol Res, 2000; 22: 815-818.
  • on 31. Li HF, Chen SA, Wu SN. Evidence for the stimulatory effect of resveratrol on Ca(2+)- activated K+ current in vascular endothelial cells. Cardiovasc Res, 2000; 45: 1035-1045.
  • Manna KS, Mukhopadhyay A, Aggarwal BB. suppresses activation of nuclear transcription factors NF- B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. J Immunol, 2000; 164: 6509-6519.
  • TNF-induced 33. Olas B, Wachowicz B, Saluk-Juszczak J, Zieliński T. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thromb Res, 2002; 15: 141–145.
  • Cain AE, Tanner DM, Khalil RA. Endothelin-1--induced coronary smooth muscle contraction via MAPK-dependent and MAPK-independent [Ca(2+)]
  • Hypertension, 2002; 39: 543-549. of sensitization pathways. 35. El-Mowafy AM, White RE. Resveratrol inhibits translocation in coronary artery smooth muscle: reversal of endothelin-1 stimulatory effects. FEBS Lett, 1999; 14: 63-67.
  • nuclear Naderali EK, Smith SL, Doyle PJ, Williams G. The mechanism of resveratrol-induced vasorelaxation differs in the mesenteric resistance arteries of lean and obese rats. Clin Sci (Lond), 2001; 100: 55-60.
  • Naderali EK, Doyle PJ, Williams G. Resveratrol mesenteric and uterine arteries from female guinea-pigs. Clin Sci (Lond), 2000; 98: 537- 543.
  • Voldby B, Enevoldsen EM, Jensen FT. Cerebrovascular reactivity in patients with ruptured intracranial aneurysms. J Neurosurg, 1985; 62: 59-67. vasorelaxation of 39. Yundt KD, Grubb RL, Diringer MN, Powers WJ.
  • parenchymal vessels is impaired during cerebral vasospasm. J Cereb Blood Flow Metab, 1998; 18: 419-424.
  • of 40. Bederson JB, Levy AL, Ding WH, et al. Acute vasoconstriction after subarachnoid hemorrhage. Neurosurg, 1998; 42: 352-362.
  • Morikawa E, Moskowitz MA, Huang Z, et al. L-arginine infusion promotes nitric oxide- dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat. Stroke, 1994; 25: 429-435. 42. Zhang F, Iadecola C. Nitroprusside improves blood flow and reduces brain damage after focal ischemia. Neuroreport, 1993; 4: 559- 562.
  • Hino A, Tokuyama Y, Weir B, et al. Changes in endothelial nitric oxide synthase mRNA during hemorrhage in monkeys. Neurosurg, 1996; 39: 562-567. after
  • subarachnoid 44. Cho HG, Shin HK, Shin YW, Lee JH, Hong KW. Role of nitric oxide in the CBF autoregulation during acute stage after subarachnoid haemorrhage in rat pial artery. Fundam Clin Pharmacol, 2003; 17: 563 -573. Correspondence address: Fuat TORUN (MD)

The Effect Of Resveratrol On Vasospasm In Experimental Triple Subarachnoid Hemorrhage Model

Year 2008, Volume: 5 Issue: 3, 9 - 15, 01.12.2008

Abstract

Backgraund Cerebral vasospasm which follows aneurysmal subarachnoid hemorrhage has an important impact on mortality and morbidity. Despite many studies, the exact etiology and pathogenesis of cerebral vasospasm have yet to be fully understood and an appropriate treatment method has not yet been identified. In this study, the effects of resveratrol on acute phase of vasospasm, which was developed in the basilar artery by a triple subarachnoid hemorrhage SAH model, were examined angiographically in rabbits. Methods In this study, the effects of resveratrol and its solvent dimethyl sulfoxide DMSO on the basilar arterial vasospasm were evaluated by angiography in an experimental triple subarachnoid hemorrhage model which was performed on 6 groups of New Zealand rabbits. Each group consisting of 8 rabbits and forty-eight rabbits were studied totally. Results Statistical analysis to compare measurements before and after resveratrol in SAH - rabbits Group 3 revealed no difference p>0.05 . In the SAH + group in which resveratrol was used for treatment Group 6 , comparison of the basilar artery diameter obtained at the 15th minute and 72nd hour of SAH showed significant improvement p

References

  • Heros RC, Zervas NT, Varsos V. Cerebral vasospasm after subarachnoid hemorrhage: an update. Ann Neurol, 1983; 14: 599-608.
  • Cook DA. Mechanisms of cerebral vasospasm in subarachnoid hemorrhage. Pharmacol Ther, 1995; 66: 259-284.
  • Bell TE, Kongable GL. Innovations in aneurysmal intracisternal t-PA for the prevention of vasospasm. J Neurosci Nurs, 1996; 28: 107- 113.
  • hemorrhage: 4. Miburn JM, Moran CJ, Cross DT. Increase in diameters of vasospastic intracranial arteries by intraarterial papaverine administration. J Neurosurg, 1998; 88: 38-42.
  • Elmali N, Esenkaya I, Harma A, et al. Effect of resveratrol in experimental osteoarthritis in rabbits. Inflamm Res, 2005; 54: 158–162. 6.
  • Goldberg D, Tsang E, Karuanchiri A, et al. Method to assay the concentrations of phenolic constituents of biological interest in wines. Anal Chem, 1996; 68: 1688–1694.
  • Das S, Alagappan VK, Bagchi D, et al. Coordinated induction of iNOS-VEGF-KDR- eNOS after resveratrol consumption: a potential preconditioning
  • Pharmacol, 2005; 42: 281-289. resveratrol the heart. Vascul 8. Bhat KPL, Kosmeder JW, Pezzuto JM. Biological
  • Antioxid Redox Signal, 2001; 3:1041–1064. of resveratrol. 9. Kimura Y. New anticancer agents: in vitro and in vivo evaluation of the antitumor and antimetastatic actions of various compounds isolated from medicinal plants. In Vivo, 2005;19: 37-60.
  • Dobrydneva Y, Williams RL, Blackmore PF. Trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br J Pharmacol, 1999; 128:149–157.
  • Sancak T, Silav G, Egemen N, Aldur M. Subarachnoid heamorrhage-induced chronic cerebral vasospasm in the rabbit: IV-DSA versus IA-DSA.Acta Neurochir (Wien) 2002; 144: 929-931.
  • Wang Q, Xu J, Rottinghaus GE, et al. Resveratrol protects against global cerebral ischemic injury in gerbils. Brain Res, 2002; 958: 439–447.
  • Sinha K, Chaudhary G, Gupta YK. Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats. Life Sci, 2002; 71: 655–665.
  • Kassel NF, Peerless SJ, Durward QJ. Treatment vasospasm expansion and induced arterial hypertension. Neurosurg, 1982; 11: 337-343.
  • Yano K, Kuroda T, Tanabe Y. Preventive therapy against delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: trials of thromboxane A2 synthetase inhibitor and hyperdynamic therapy. Acta Neurochir (Wien), 1993; 125: 15-19.
  • Feigin VL, Rinkel GJE, Algra A. Calcium antagonists in patients with aneurysmal subarachnoid hemorrhage. Neurology, 1998; 50: 876-882.
  • Haley EC Jr, Kassel NF, Torner JC. A randomized controlled trial of high dose intravenous
  • subarachnoid hemorrhage: a report of the cooperative aneurysm study. J Neurosurg, 1993; 78: 537-547. in
  • aneurysmal 18. Fandino J, Kaku Y, Schuknecht B. Improvement of cerebral oxygenation patterns and metabolic validation of super selective intraarterial infusion of papaverine for the treatment of cerebral vasospasm. J Neurosurg, 1998; 89: 93-100.
  • Polin RS, Hansen CA, German P. Intra- arterially administered papaverine treatment of Neurosurg, 1997; 42: 1256-1267.
  • vasospasm. 20. Shiokawa K, Kasuya H, Miyajima M, Izawa M, Takakura K. Prophylactic effect of papaverine
  • cerebral vasospasm in dogs. Neurosurg, 1998; 42: 109-116. pellets on 21. Alabadi JA, Torregrosa G, Miranda FJ, et al. Impairment of the modulatory role of nitric oxide on the endothelin-1-elicited contraction of cerebral arteries: a pathogenetic factor in cerebral hemorrhage. Neurosurg, 1997; 41: 245-252.
  • Pluta RM, Oldfield EH, Boock RJ. Reversal and prevention of cerebral vasospasm by intracarotid infusions of nitric oxide donors in a primate model of subarachnoid hemorrhage. J Neurosurg, 1997; 87: 746-751.
  • Kwan AL, Bavbek M, Jeng AY, et al. Prevention and reversal of cerebral vasospasm by an endothelin-converting enzyme inhibitor, CGS 26303, in an experimental model of subarachnoid hemorrhage. J Neurosurg, 1997; 87: 281-286.
  • Kwan AL, Lin CL, Yanamoto H, et al. Systemic administration of the potassium channel activator cromakalim attenuates cerebral
  • subarachnoid hemorrhage. Neurosurg, 1998; 42: 347-350. after experimental The effect of intrathecal sodium nitroprusside on severe chronic vasospasm. Neurol Res, 1993; 15: 310–315.
  • Chyatte D, Fode NC, Nichols DA, Sundt TM Jr. Preliminary report: effects of high dose methylprednisolone on delayed cerebral ischemia in patients at high risk for vasospasm after aneurysmal subarachnoid hemorrhage. Neurosurg, 1987; 21: 157-160.
  • Bagdatoglu C, Guleryuz A, et al. Resolution of cerebral vasospasm with trapidil; an animal model. J Clin Neurosci, 2002; 9: 429–432.
  • Egemen N, Baskaya MK, Turker RK, et al. Protection by iloprost (stable analogue of prostacyclin) of endothelial damage due to chronic vasospasm in dogs: an electron microscope study. Neurol Res, 1995; 17: 301- 306.
  • Egemen N, Turker RK, Sanlidilek U. The effect of iloprost on chronic cerebral vasospasm. Gen Pharmac, 1993; 24: 403-409. 30. Ergun H, Bagdatoglu C, Ugur H, et al. Vasorelaxant
  • experimental vasospasm model in rabbits. Neurol Res, 2000; 22: 815-818.
  • on 31. Li HF, Chen SA, Wu SN. Evidence for the stimulatory effect of resveratrol on Ca(2+)- activated K+ current in vascular endothelial cells. Cardiovasc Res, 2000; 45: 1035-1045.
  • Manna KS, Mukhopadhyay A, Aggarwal BB. suppresses activation of nuclear transcription factors NF- B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. J Immunol, 2000; 164: 6509-6519.
  • TNF-induced 33. Olas B, Wachowicz B, Saluk-Juszczak J, Zieliński T. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thromb Res, 2002; 15: 141–145.
  • Cain AE, Tanner DM, Khalil RA. Endothelin-1--induced coronary smooth muscle contraction via MAPK-dependent and MAPK-independent [Ca(2+)]
  • Hypertension, 2002; 39: 543-549. of sensitization pathways. 35. El-Mowafy AM, White RE. Resveratrol inhibits translocation in coronary artery smooth muscle: reversal of endothelin-1 stimulatory effects. FEBS Lett, 1999; 14: 63-67.
  • nuclear Naderali EK, Smith SL, Doyle PJ, Williams G. The mechanism of resveratrol-induced vasorelaxation differs in the mesenteric resistance arteries of lean and obese rats. Clin Sci (Lond), 2001; 100: 55-60.
  • Naderali EK, Doyle PJ, Williams G. Resveratrol mesenteric and uterine arteries from female guinea-pigs. Clin Sci (Lond), 2000; 98: 537- 543.
  • Voldby B, Enevoldsen EM, Jensen FT. Cerebrovascular reactivity in patients with ruptured intracranial aneurysms. J Neurosurg, 1985; 62: 59-67. vasorelaxation of 39. Yundt KD, Grubb RL, Diringer MN, Powers WJ.
  • parenchymal vessels is impaired during cerebral vasospasm. J Cereb Blood Flow Metab, 1998; 18: 419-424.
  • of 40. Bederson JB, Levy AL, Ding WH, et al. Acute vasoconstriction after subarachnoid hemorrhage. Neurosurg, 1998; 42: 352-362.
  • Morikawa E, Moskowitz MA, Huang Z, et al. L-arginine infusion promotes nitric oxide- dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat. Stroke, 1994; 25: 429-435. 42. Zhang F, Iadecola C. Nitroprusside improves blood flow and reduces brain damage after focal ischemia. Neuroreport, 1993; 4: 559- 562.
  • Hino A, Tokuyama Y, Weir B, et al. Changes in endothelial nitric oxide synthase mRNA during hemorrhage in monkeys. Neurosurg, 1996; 39: 562-567. after
  • subarachnoid 44. Cho HG, Shin HK, Shin YW, Lee JH, Hong KW. Role of nitric oxide in the CBF autoregulation during acute stage after subarachnoid haemorrhage in rat pial artery. Fundam Clin Pharmacol, 2003; 17: 563 -573. Correspondence address: Fuat TORUN (MD)
There are 44 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Fuat Torun This is me

Hakan Tuna This is me

Tanzer Sancak This is me

Emine Demırel This is me

Celal Bagdatoglu This is me

Nihat Egemen This is me

Publication Date December 1, 2008
Published in Issue Year 2008 Volume: 5 Issue: 3

Cite

Vancouver Torun F, Tuna H, Sancak T, Demırel E, Bagdatoglu C, Egemen N. The Effect Of Resveratrol On Vasospasm In Experimental Triple Subarachnoid Hemorrhage Model. Harran Üniversitesi Tıp Fakültesi Dergisi. 2008;5(3):9-15.

Harran Üniversitesi Tıp Fakültesi Dergisi  / Journal of Harran University Medical Faculty