Deneysel Üçlü Subaraknoid Kanama Modelinde Resveratrolün Vazospazm Üzerine Etkisi

Yıl 2008, Cilt: 5 Sayı: 3, 9 - 15, 01.12.2008

Fuat Torun Hakan Tuna Tanzer Sancak Emine Demırel Celal Bagdatoglu Nihat Egemen

Öz

Amaç Anevrizmal subaraknoid kanamayı takiben gelişen serebral vazospazmın mortalite ve morbidite üzerinde önemli etkileri vardır. Yapılmış olan pek çok çalışmaya rağmen serebral vazospazmın kesin nedeni ve etiyolojisi bilinmemektedir ve uygun bir tedavi yöntemi de henüz belirlenmemiştir. Bu çalışmada resveratrolün üçlü subaraknoid kanama SAK modeli ile tavşan baziler arterinde oluşturulan akut serebral vazospazm üzerine etkisi anjiyografik olarak incelenmiştir Gereç ve yöntem Bu çalşımada 6 grup Yeni Zelanda tavşanında deneysel olarak oluşturulan üçlü subaraknoid kanama modelinde resveratrol ve çözücüsü dimetil sülfoksitin baziler arterdeki vazospazm üzerine etkisi anjiyografi ile değerlendirilmiştir. Her grupta 8 tavşan bulunuyordu ve toplam 48 tavşan çalışmaya dahil edildi. Bulgular SAK - tavşanlarda 3. Grup resveratrol öncesi ve sonrası ölçümler arasında istatistiksel olarak bir fark yoktu p>0.05 . tedavi için resveratrolün kullanıldığı SAK + grupta 6. Grup 15. Dakika ve 72. Saatte elde edilen baziler arter çapları karşılaştırıldığında anlamlı bir düzelme olduğu görüldü p

Anahtar Kelimeler

Resveratrol, serebral vasospasm, anjiyografi, basiller arter, tavşan

The Effect Of Resveratrol On Vasospasm In Experimental Triple Subarachnoid Hemorrhage Model

Öz

Backgraund Cerebral vasospasm which follows aneurysmal subarachnoid hemorrhage has an important impact on mortality and morbidity. Despite many studies, the exact etiology and pathogenesis of cerebral vasospasm have yet to be fully understood and an appropriate treatment method has not yet been identified. In this study, the effects of resveratrol on acute phase of vasospasm, which was developed in the basilar artery by a triple subarachnoid hemorrhage SAH model, were examined angiographically in rabbits. Methods In this study, the effects of resveratrol and its solvent dimethyl sulfoxide DMSO on the basilar arterial vasospasm were evaluated by angiography in an experimental triple subarachnoid hemorrhage model which was performed on 6 groups of New Zealand rabbits. Each group consisting of 8 rabbits and forty-eight rabbits were studied totally. Results Statistical analysis to compare measurements before and after resveratrol in SAH - rabbits Group 3 revealed no difference p>0.05 . In the SAH + group in which resveratrol was used for treatment Group 6 , comparison of the basilar artery diameter obtained at the 15th minute and 72nd hour of SAH showed significant improvement p

Anahtar Kelimeler

Resveratrol, cerebral vasospasm, angiography, basilar artery, rabbit

Kaynakça

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