Case Report
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Kingella Denitrificans’ın Neden Olduğu Kateterle İlişkili Kan Dolaşımı Enfeksiyonu: Bir Vaka Raporu

Year 2025, Volume: 22 Issue: 3, 618 - 620, 29.09.2025
https://doi.org/10.35440/hutfd.1649413

Abstract

Kingella denitrificans, nadir görülmesine rağmen insanlarda patojen olabilen gram-negatif bir kokobasildir. Literatürde endokardit ve peritonit gibi enfeksiyonlara dair vakalar bildirilmiştir. Bu çalışmada, daha önce belgelenmemiş Kingella denitrificans kaynaklı kateterle ilişkili bir kan dolaşımı enfeksiyonunu sunuyoruz. Mikroorganizma için bir antibiyogram testi yapılmamış olmasına rağmen, intravenöz meropenem tedavisi ve enfekte olmuş kalıcı tünelli subklavyen kateterin çıkarılmasıyla klinik ve laboratuvar bulgularında iyileşme sağlanmıştır.

References

  • 1. Murphy TF. Moraxella catarrhalis, Kingella, and Other Gram-Negative Cocci. In: Bennett JE, Dolin R, Blaser MJ (eds). Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. Elsevier: Amsterdam, The Netherlands; 2019, pp: 2628-35
  • 2. Yagupsky P, Greenberg D. Kingella species. In: Sarah S. Long (ed) Principles and Practice of Pediatric Infectious Diseases. Philadelphia Elsevier Inc 2012, p: 919-922.
  • 3. Lehenaff R, Tamashiro R, Nascimento MM, Lee K, Jenkins R, Whitlock J, et al. Subgingival microbiome of deep and shal-low periodontal sites in patients with rheumatoid arthritis: a pilot study. BMC Oral Health. 2021;21(1):248. https://doi.org/10.17026/dans-zsb-wg2f
  • 4. Weir S, Lee LW, Marrs CF. Type-4 pili of Kingella denitrifi-cans. Gene. 1997;192(1):171-6. https://doi.org/10.1016/S0378-1119(96)00828-1
  • 5. Kocyigit I, Öztürk F, Kargi S, Uzun I, Unal A, Tokgoz B. Perito-neal Dialysis-Related Peritonitis Due toKingella Denitrificans: The First Case Report. Perit Dial Int. 2014;34(7):819-20. https://doi.org/10.3747/pdi.2013.00149
  • 6. Khan JA, Sharp S, Mann KR, Brewer J. Case Report: Kingella denitrificans Prosthetic Endocarditis. Am J Med Sci. 1986; 291(3):187-9. https://doi.org/10.1097/00000441-198603000-00009
  • 7. Maccato M, McLean W, Riddle G, Faro S. Isolation of Kingella denitrificans from amniotic fluid in a woman with chorioam-nionitis. A case report. J Reprod Med. 1991; 36(9):685-7.
  • 8. Knapp JS, Johnson SR, Zenilman JM, Roberts MC, Morse SA. High-level tetracycline resistance resulting from TetM in strains of Neisseria spp., Kingella denitrificans, and Eikenella corrodens. Antimicrob Agents Chemother. 1988; 32(5):765-7. https://doi.org/10.1128/aac.32.5.765
  • 9. Matuschek E, Åhman J, Kahlmeter G, Yagupsky P. Antimicro-bial susceptibility testing of Kingella kingae with broth mic-rodilution and disk diffusion using EUCAST recommended media. Clinical Microbiology and Infection. 2018; 24(4):396-401. https://doi.org/10.1016/j.cmi.2017.07.019
  • 10. Baang JH, Inagaki K, Nagel J, Ramani K, Stillwell TL, Mack M, et al. Inpatient Diagnosis and Treatment of Catheter-Related Bloodstream Infection [Internet]. Ann Arbor (MI): Michigan Medicine University of Michigan; 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK589895/

Catheter-Related Bloodstream Infection Caused by Kingella Denitrificans: A Case Report

Year 2025, Volume: 22 Issue: 3, 618 - 620, 29.09.2025
https://doi.org/10.35440/hutfd.1649413

Abstract

Kingella denitrificans is a gram-negative coccobacillus that, although rare, can be a human pathogen. Infections such as endocarditis and peritonitis have been reported in the literature. Here, we report a previously undocumented catheter-related bloodstream infection caused by Kingella denitrificans. Although an antibiogram was not performed for the microorganism, clinical and laboratory findings improved with intravenous meropenem treatment and the re-moval of the infected permanent tunneled subclavian catheter.

References

  • 1. Murphy TF. Moraxella catarrhalis, Kingella, and Other Gram-Negative Cocci. In: Bennett JE, Dolin R, Blaser MJ (eds). Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. Elsevier: Amsterdam, The Netherlands; 2019, pp: 2628-35
  • 2. Yagupsky P, Greenberg D. Kingella species. In: Sarah S. Long (ed) Principles and Practice of Pediatric Infectious Diseases. Philadelphia Elsevier Inc 2012, p: 919-922.
  • 3. Lehenaff R, Tamashiro R, Nascimento MM, Lee K, Jenkins R, Whitlock J, et al. Subgingival microbiome of deep and shal-low periodontal sites in patients with rheumatoid arthritis: a pilot study. BMC Oral Health. 2021;21(1):248. https://doi.org/10.17026/dans-zsb-wg2f
  • 4. Weir S, Lee LW, Marrs CF. Type-4 pili of Kingella denitrifi-cans. Gene. 1997;192(1):171-6. https://doi.org/10.1016/S0378-1119(96)00828-1
  • 5. Kocyigit I, Öztürk F, Kargi S, Uzun I, Unal A, Tokgoz B. Perito-neal Dialysis-Related Peritonitis Due toKingella Denitrificans: The First Case Report. Perit Dial Int. 2014;34(7):819-20. https://doi.org/10.3747/pdi.2013.00149
  • 6. Khan JA, Sharp S, Mann KR, Brewer J. Case Report: Kingella denitrificans Prosthetic Endocarditis. Am J Med Sci. 1986; 291(3):187-9. https://doi.org/10.1097/00000441-198603000-00009
  • 7. Maccato M, McLean W, Riddle G, Faro S. Isolation of Kingella denitrificans from amniotic fluid in a woman with chorioam-nionitis. A case report. J Reprod Med. 1991; 36(9):685-7.
  • 8. Knapp JS, Johnson SR, Zenilman JM, Roberts MC, Morse SA. High-level tetracycline resistance resulting from TetM in strains of Neisseria spp., Kingella denitrificans, and Eikenella corrodens. Antimicrob Agents Chemother. 1988; 32(5):765-7. https://doi.org/10.1128/aac.32.5.765
  • 9. Matuschek E, Åhman J, Kahlmeter G, Yagupsky P. Antimicro-bial susceptibility testing of Kingella kingae with broth mic-rodilution and disk diffusion using EUCAST recommended media. Clinical Microbiology and Infection. 2018; 24(4):396-401. https://doi.org/10.1016/j.cmi.2017.07.019
  • 10. Baang JH, Inagaki K, Nagel J, Ramani K, Stillwell TL, Mack M, et al. Inpatient Diagnosis and Treatment of Catheter-Related Bloodstream Infection [Internet]. Ann Arbor (MI): Michigan Medicine University of Michigan; 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK589895/
There are 10 citations in total.

Details

Primary Language English
Subjects Infectious Diseases
Journal Section Case Report
Authors

Murtaza Öz 0000-0003-3415-5927

Özlem Aldemir 0000-0002-9356-7510

Early Pub Date September 29, 2025
Publication Date September 29, 2025
Submission Date March 1, 2025
Acceptance Date July 16, 2025
Published in Issue Year 2025 Volume: 22 Issue: 3

Cite

Vancouver Öz M, Aldemir Ö. Catheter-Related Bloodstream Infection Caused by Kingella Denitrificans: A Case Report. Harran Üniversitesi Tıp Fakültesi Dergisi. 2025;22(3):618-20.