Determination of haptoglobin, ceruloplasmin and some biochemical parameters before and after treatment in dogs with babesiosis

Abstract

In this study, it was aimed to determine haptoglobin (Hp), ceruloplasmin (Cp) and some biochemical parameters levels before and after treatment in dogs naturally infected with babesiosis. Animal material of the study consisted of 10 dogs of different age and sex. There were icterus, hemoglobinuria and lack of appetite in dogs. After clinical examination and Giemsa staining, disease was diagnosed by the presence of agents in erythrocytes. After diagnosis, blood samples were taken from animals before and after treatment and sera was separated. In these sera, Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) enzyme activities, Hp, Cp, urea and creatinine levels were determined. Pre-treatment ALT (P<0.05) and AST (P<0.05) enzyme activities, urea (P<0.05), creatinine (P<0.05) and Cp (P<0.001) levels were determined higher than post-treatment. Pre-treatment Hp level was determined lower compared to post-treatment level (P<0.001). As a result, significant changes in ALT and AST enzyme activities, urea, creatinine, Hp and Cp levels were determined in dogs with Babesiosis. It was concluded that follow-up of these parameters may be important in the prognosis and treatment process of the disease in dogs.

Keywords

• Dog,Babesiosis,Haptoglobin,Ceruloplasmin

Babesiosis’li köpeklerde tedavi öncesi ve sonrası haptoglobin, seruloplazmin ve bazı biyokimyasal parametrelerin seviyelerinin belirlenmesi

Abstract

Bu çalışmada babesiosis ile doğal enfekte köpeklerde tedavi öncesi ve sonrası haptoglobin (Hp), seruloplazmin (Cp) ve bazı biyokimyasal parametrelerin seviyelerinin belirlenmesi amaçlanmıştır. Çalışmanın hayvan materyalini, iştahsızlık, ikterus ve hemoglobinüri şikayetleri olan farklı yaş ve cinsiyette 10 köpek oluşturdu. Klinik muayeneler ve Giemsa boyama sonrasında eritrositler içerisinde etkenlerin görülmesi ile tanı kondu. Tanı sonrasında tedavi öncesi ve sonrası hayvanlardan kan alınarak serumları ayrıştırıldı. Bu serumlarda Alanin aminotransferaz (ALT) ve Aspartat aminotransferaz (AST) enzim aktiviteleri, Hp, Cp, üre ve kreatinin seviyeleri belirlendi. Tedavi öncesi ALT (P<0.05) ve AST (P<0.05) enzim aktiviteleri ile üre (P<0.05), kreatinin (P<0.05) ve Cp (P<0.001), seviyeleri tedavi sonrasına göre yüksek belirlendi. Hp seviyesi ise tedavi öncesinde tedavi sonrasına göre düşük bulundu (P<0.001). Sonuç olarak Babesiosis’li köpeklerde ALT ve AST enzim aktiviteleri ile üre, kreatinin, Hp ve Cp seviyelerinde önemli değişikliklerin olduğu belirlendi. Köpeklerde babesiosis hastalığının prognozunda ve tedavi sürecinde bu parametrelerin takibinin önemli olabileceği kanaatine varıldı. 

Keywords

• Köpek,Babesiosis,Haptoglobin,Seruloplazmin

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