Babesiosis’li köpeklerde tedavi öncesi ve sonrası haptoglobin, seruloplazmin ve bazı biyokimyasal parametrelerin seviyelerinin belirlenmesi

Year 2019, , 77 - 80, 01.07.2019

Ekin Emre Erkılıç

https://doi.org/10.31196/huvfd.592564

Cited By: 1

Abstract

Bu çalışmada babesiosis ile doğal enfekte köpeklerde
tedavi öncesi ve sonrası haptoglobin (Hp), seruloplazmin (Cp) ve bazı
biyokimyasal parametrelerin seviyelerinin belirlenmesi amaçlanmıştır.
Çalışmanın hayvan materyalini, iştahsızlık, ikterus ve hemoglobinüri
şikayetleri olan farklı yaş ve cinsiyette 10 köpek oluşturdu. Klinik muayeneler
ve Giemsa boyama sonrasında eritrositler içerisinde etkenlerin görülmesi ile
tanı kondu. Tanı sonrasında tedavi öncesi ve sonrası hayvanlardan kan alınarak
serumları ayrıştırıldı. Bu serumlarda Alanin aminotransferaz (ALT) ve Aspartat
aminotransferaz (AST) enzim aktiviteleri, Hp, Cp, üre ve kreatinin seviyeleri
belirlendi. Tedavi öncesi ALT (P<0.05) ve AST (P<0.05) enzim aktiviteleri
ile üre (P<0.05), kreatinin (P<0.05) ve Cp (P<0.001), seviyeleri
tedavi sonrasına göre yüksek belirlendi. Hp seviyesi ise tedavi öncesinde
tedavi sonrasına göre düşük bulundu (P<0.001). Sonuç olarak Babesiosis’li
köpeklerde ALT ve AST enzim aktiviteleri ile üre, kreatinin, Hp ve Cp
seviyelerinde önemli değişikliklerin olduğu belirlendi. Köpeklerde babesiosis
hastalığının prognozunda ve tedavi sürecinde bu parametrelerin takibinin önemli
olabileceği kanaatine varıldı. 

Keywords

Köpek, Babesiosis, Haptoglobin, Seruloplazmin

Thanks

Çalışmanın biyokimyasal analizlerin yapılmasında destek olan Doç. Dr. Oğuz MERHAN’a yardımlarından dolayı teşekkür ederim.

Determination of haptoglobin, ceruloplasmin and some biochemical parameters before and after treatment in dogs with babesiosis

Abstract

In this study, it was aimed
to determine haptoglobin (Hp), ceruloplasmin (Cp) and some biochemical
parameters levels before and after treatment in dogs naturally infected with
babesiosis. Animal material of the study consisted of 10 dogs of different age
and sex. There were icterus, hemoglobinuria and lack of appetite in dogs. After
clinical examination and Giemsa staining, disease was diagnosed by the presence
of agents in erythrocytes. After diagnosis, blood samples were taken from
animals before and after treatment and sera was separated. In these sera,
Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST) enzyme
activities, Hp, Cp, urea and creatinine levels were determined. Pre-treatment
ALT (P<0.05) and AST (P<0.05) enzyme activities, urea (P<0.05),
creatinine (P<0.05) and Cp (P<0.001) levels were determined higher than
post-treatment. Pre-treatment Hp level was determined lower compared to
post-treatment level (P<0.001). As a result, significant changes in ALT and
AST enzyme activities, urea, creatinine, Hp and Cp levels were determined in
dogs with Babesiosis. It was concluded that follow-up of these parameters may
be important in the prognosis and treatment process of the disease in dogs.

Keywords

Dog, Babesiosis, Haptoglobin, Ceruloplasmin

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