Diyabetik Hastalarda Trombosit Dağılım Genişliği (PDW), Ortalama Trombosit Hacmi (MPV) ve Vitamin D Düzeyi Arasındaki İlişkinin İncelenmesi

Öz

Amaç: Bu çalışmanın amacı, Tip 2 diabetes mellitus hastalarında vitamin D düzeyleri ile tam kan sayımı parametrelerinden ortalama trombosit hacmi (MPV) ve trombosit dağılım genişliği (PDW) düzeyleri arasındaki potansiyel ilişkinin varlığını araştırmaktır. Yöntem: Bu çalışmaya Atlas Üniversitesi Medicine Hastanesi’ne 2013-2016 yıllarında check-up taraması yapılan 1581 hasta dahil edilmiştir. Hastalarda açlık glukoz düzeylerine bakılarak kontrol grubu, bozulmuş açlık glukoz grubu ve diabetes mellitus grubu şeklinde üç gruba ayırarak retrospektif olarak inceleme yapılmıştır. İstatistiksel analizler için Shapiro-Wilks, Oneway ANOVA, Tukey HDS, Kruskal Wallis, Mann Whitney U ve Ki-Kare testleri yapılmıştır. Ayrıca, değişkenler arasındaki doğrusal ilişkinin şiddeti ve yönünün belirlenmesinde korelasyon analizine (Pearson, Spearman’ın Rho testi) başvurulmuştur. Bulgular: Yapılan istatiksel analizlerde diabetes mellitus grubunda, bozulmuş açlık glukoz grubunda ve kontrol grubunda ortalama trombosit hacmi ve trombosit dağılım genişliği ile 25(OH)D3 vitamini düzeyi açısından istatistiksel olarak anlamlı düzeyde bir korelasyon tespit edilmemiştir (p>0,05). Sonuç: Bu çalışmanın sonucunda ortaya çıkan bulgular ışığında; 25(OH)D3 vitamin eksikliğinin, diabetes mellitus gelişiminde rol oynayabileceği düşünülmüştür. Yine benzer şekilde bu çalışmada ortaya çıkan bulgular ışığında hemogramın birer parametresi olan PDW ve MPV’nin, diabetes mellitusun komplikasyonlarında risk artışına neden olan gösterge şeklinde kullanımı söz konusu olabilir.

Anahtar Kelimeler

• Vitamin D
• MPV
• PDW
• tip 2 diyabet
• hemogram

Investigation of the Relationship between Platelet Distribution Width (PDW), Mean Platelet Volume (MPV) and Vitamin D Levels in Diabetic Patients

Abstract

Aim: This study aims to investigate the potential relationship between vitamin D levels and mean platelet volume and platelet distribution width levels of complete blood count parameters in Type 2 diabetes mellitus patients. Method: A total of 1581 patients who underwent check-up screening at Atlas University Medicine Hospital between 2013 and 2016 were included in this study. The fasting glucose levels of the patients were retrospectively examined by dividing them into three groups: the control group, the impaired fasting glucose group, and the diabetes mellitus group. Shapiro-Wilks, Oneway ANOVA, Tukey HDS, Kruskal-Wallis, Mann Whitney U, and Chi-Square tests were used for statistical analysis. In addition, correlation analysis (Pearson, Spearman's Rho test) was used to determine the intensity and direction of the linear relationship between the variables. Results: The statistical analyses did not reveal a statistically significant correlation between mean platelet volume and platelet distribution width and 25(OH)D3 vitamin levels in the diabetes mellitus group, the impaired fasting glucose group, and the control group (p>0.05). Conclusion: In light of the findings of this study, it was thought that 25(OH)D3 vitamin deficiency may play a role in the development of diabetes mellitus. Similarly, PDW and MPV, as hemogram parameters, could potentially serve as indicators of an increased risk for diabetes mellitus complications.

Keywords

• Vitamin D
• MPV
• PDW
• type 2 diabetes
• hemogram

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