Vitamin D in a Nutshell
Abstract
This review comprises the synthesis, function,
measurement and also the recommendations of Vitamin D and its derivates. In
light of the evidence provided by clinical trials, deficient vitamin D levels
were found to be correlated with higher incidences of rickets, skeletal
disorders, diabetes, obesity, cardio vascular disorders, asthma, depression,
schizophrenia and immune disorders. Vitamin D supplementation which is
available at low cost and with a wide therapeutic window, should be implemented
to the population and should be monitored only in patients with a high risk of
kidney and liver diseases, hyperparathyroidism, sarcoidosis, tuberculosis and
histoplasmosis.
Keywords
References
- Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014;21(3):319-329. doi:10.1016/j.chembiol.2013.12.016.
- Calcium I of M (US) C to RDRI for VD and, Ross AC, Taylor CL, Yaktine AL, Valle HB Del. Dietary Reference Intakes for Calcium and Vitamin D. National Academies Press (US); 2011. doi:10.17226/13050.
- Havinga E. Vitamin D, example and challenge. Experientia. 1973;29(10):1181-1193. http://www.ncbi.nlm.nih.gov/pubmed/4758912. Accessed January 26, 2017.
- Jäpelt RB, Jakobsen J. Vitamin D in plants: a review of occurrence, analysis, and biosynthesis. Front Plant Sci. 2013;4:136. doi:10.3389/fpls.2013.00136.
- Chun RF, Peercy BE, Orwoll ES, Nielson CM, Adams JS, Hewison M. Vitamin D and DBP: The free hormone hypothesis revisited. J Steroid Biochem Mol Biol. 2014;144 (PART A):132-137. doi:10.1016/j.jsbmb.2013.09.012.
- Tripkovic L, Lambert H, Hart K, et al. Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. Am J Clin Nutr. 2012;95(6):1357-1364. doi:10.3945/ajcn.111.031070.
- Gressner OA, Lahme B, Gressner AM. Gc-globulin (vitamin D binding protein) is synthesized and secreted by hepatocytes and internalized by hepatic stellate cells through Ca2+-dependent interaction with the megalin/gp330 receptor. Clin Chim Acta. 2008;390(1-2):28-37. doi:10.1016/j.cca.2007.12.011.
- Christakos S, Ajibade D V, Dhawan P, Fechner AJ, Mady LJ. Vitamin D: metabolism. Endocrinol Metab Clin North Am. 2010;39(2):243-53, table of contents. doi:10.1016/j.ecl.2010.02.002.
Details
Primary Language
Turkish
Subjects
Clinical Sciences
Journal Section
Review
Authors
Başak Gökçe Çöl
İSTANBUL GELİŞİM ÜNİVERSİTESİ
Türkiye
Eda Merve Kurtuluş
İSTANBUL GELİŞİM ÜNİVERSİTESİ
Türkiye
Fuzail Mohammed Majoo
This is me
İSTANBUL GELİŞİM ÜNİVERSİTESİ
Türkiye
Publication Date
April 26, 2017
Submission Date
February 20, 2017
Acceptance Date
April 4, 2017
Published in Issue
Year 2017 Number: 1