Investigation of the Effect of Maternal Stress Caused by Earthquake and Covid-19 Epidemic on Pre/eclampsia

Year 2024, Issue: 23, 708 - 721, 31.08.2024

Özlem Koç , Ahmet Şenocak , Bünyamin Çim , Salih Kavak

Abstract

Aim: To examine the effects of the earthquake that occurred in Elazig on January 24, 2020 and the COVID-19 epidemic that spread throughout Turkey on April 1, 2020, on the pre/eclampsia spectrum.
Method: The study was conducted by retrospectively examining the files of pregnant women who applied to the Fırat University Faculty of Medicine, Department of Obstetrics and Gynecology for birth between July 1, 2019 and March 1, 2021. The cases in group 1 were determined by examining the pregnant women who gave birth between July 1, 2019 – January 1, 2020, those with pre-eclampsia, HELLP syndrome, and superimposed preeclampsia, and the cases in group 2 with the same diagnoses between September 1, 2020 and March 1, 2021.
Results: A total of 605 deliveries took place between July 1, 2019 and January 1, 2020 (group 1). A total of 654 births took place between September 1, 2020 - March 1, 2021 (group 2). While the incidence of preeclampsia and related diseases was 4.8% in group 1, it was 7.5% in group 2 (change rate +56.2%). Severe preeclampsia (+103.3%) was the disease whose frequency increased the most after maternal stress.
Conclusion: In the study, it was determined that maternal stress significantly increased the incidence of preeclampsia and related diseases. After events that cause severe stress, health care providers need to be prepared.

Keywords

COVID-19 pandemic, earthquake, maternal stress, pre/eclampsia

Deprem ve COVID-19 Salgınının Neden Olduğu Maternal Stresin Pre/eklampsi Üzerine Olan Etkisinin İncelenmesi

Abstract

Amaç: 24 Ocak 2020 tarihinde Elazığ’da meydana gelen deprem ve 1 Nisan 2020’de Türkiye geneline yayılan COVID-19 salgınının pre/eklampsi spekturumu üzerine olan etkilerinin incelenmesi.
Yöntem: Çalışma 1 Temmuz 2019 ile 1 Mart 2021 tarihleri arasında doğum için Fırat Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Kliniği’ne başvuran gebelerin dosyalarının retrospektif olarak incelenmesi yoluyla yapıldı. Grup 1’deki olgular 1 Temmuz 2019 – 1 Ocak 2020 tarihleri arasında doğum yapan gebelerin pre-eklampsi, HELLP sendromu ve süperempoze preeklampsi olanlar ve Grup 2’deki olgular 1 Eylül 2020 – 1 Mart 2021 tarihleri arasında aynı tanılara sahip olan gebelerin incelenmesi yoluyla belirlendi.
Bulgular: 1 Temmuz 2019 – 1 Ocak 2020 tarihleri arasında (Grup 1) toplam 605 doğum gerçekleşti. 1 Eylül 2020 – 1 Mart 2021 tarihleri arasında (Grup 2) toplam 654 doğum gerçekleşti. Grup 1’de preeklampsi ve ilişkili hastalıkların insidansı %4,8 iken, Grup 2’de bu oran %7,5 olarak gerçekleşmiştir (değişim oranı +%56,2). Maternal stres sonrası sıklığı en fazla artan hastalık şiddetli preeklampsi (+%103,3) olmuştur.
Sonuç: Çalışmada, maternal stresin preeklampsi ve ilişkili hastalıkların insidansını belirgin derecede arttırdığı tespit edilmiştir. Ağır strese neden olan olaylar sonrasında, sağlık hizmeti sunucularının hazırlıklı olması gerekmektedir.

Keywords

COVID-19 pandemisi, deprem, maternal stres, pre/eklampsi

References

• 1. Chen CH. Revision and validation of a scale to assess pregnancy stress. J Nurs Res. 2015;23(1):25–32. doi: 10.1097/jnr.0000000000000047.
• 2. Catalano R, Bruckner T, Gould J, Eskenazi B, Anderson E. Sex ratios in California following the terrorist attacks of September 11, 2001. Hum. Reprod. 2005;20:1221–1227. doi: 10.1093/humrep/deh763.
• 3. James WH, Valentine J. A further note on the rises in sex ratio at birth during and just after the two World Wars. J. Theor. Biol. 2014;363:404–411. doi: 10.1016/j.jtbi.2014.08.004.
• 4. Dunkel Schetter C, Tanner L. Anxiety, depression and stress in pregnancy: implications for mothers, children, research, and practice. Curr Opin Psychiatry. 2012;25:141-8. doi: 10.1097/YCO.0b013e3283503680.
• 5. Coussons-Read ME. Effects of prenatal stress on pregnancy and human development: Mechanisms and pathways. Obstetric Medicine. 2013;6(2):52–57. doi: 10.1177/1753495x12473751.
• 6. Breitkopf CR, Primeau AL, Levine ER, Olson GL, Wu HZ, Berenson AB. Anxiety symptoms during pregnancy and postpartum. Journal of Psychosomatic Obstetrics and Gynecology. 2006;27(3):157-62. doi: 10.1080/01674820500523521.
• 7. Kramer MS, Lydon J, Seguin L, et al. Stress pathways to spontaneous preterm birth: the role of stressors, psychological distress and stress hormones. Am J Epidemiol. 2009;169:1319-1326. doi: 10.1093/aje/kwp061.
• 8. Li S, Chen H. Modeling the epidemic dynamics and control of COVID-19 outbreak in China. Quant Biol. 2020;11:1-9. doi: 10.1007/s40484-020-0199-0.
• 9. Li S, Wang Y, Xue J, Zhao N, Zhu T. The impact of COVID-19 epidemic declaration on psychological consequences: a study on active Weibo users. Int J Environ Res Public Health. 2020;17(6):2032.
• 10. Türkiye İstatistik Kurumu (TÜİK). Coronavirus disease (COVID19) data in Turkey [Online]. Available from: https://www.tuik.gov.tr/. Accessed March 8, 2021.
• 11. Boğaziçi University Kandilli Observatory and Earthquake Research Institute Regional Earthquake-Tsunami Monitoring and Evaluation Center. Earthquake data in Turkey [Online]. Available from: : https://www.koeri.boun.edu.tr/. Accessed March 8, 2021.
• 12. Mertol HC, Akış T, Tunç G. 24.01.2020 Elazig-Sivrice Earthquake Assessment Report, Atılım University, Department of Civil Engineering October 2021;1-130.
• 13. Atatürk University Earthquake Research Center 24 January 2020 (20:55 TT) Mw=6.8, Elazig Sivrice Earthquake Assessment Report 2020;1-20.
• 14. Şıkoğlu E, Güney YE. A Geographical Assessment on the Reflection of the 24 January 2020 Sivrice (Elazig) Earthquake in the City Center. Journal of Direnclilik. 2020;4(2):275-292.
• 15. Tegethoff M, Greene N, Olsen J, Meyer AH, Meinlschmidt G. Maternal psychosocial adversity during pregnancy is associated with length of gestation and offspring size at birth: evidence from a populationbased cohort study. Psychosom Med. 2010;72:419-426.
• 16. Torche F, Kleinhaus K. Prenatal stress, gestational age and secondary sex ratio: the sex-specific effects of exposure to a natural disaster in early pregnancy. Hum Reprod. 2012;27(2):558-67.
• 17. Wang C, Pan R, Wan X, et al. Immediate psychological responses and associated factors during the initial stage of the 2019 Coronavirus Disease (COVID-19) Epidemic among the General Population in China. Int J Environ Res Public Health. 2020;17(5):1729.
• 18. Hamel L, Salganicoff A. Is there a widening gender gap in coronavirus stress? Kaiser Family Foundation 2020. https://www.kff.org/coronavirus-policy-watch/is-there-widening-gender-gap-in-coronavirusstress.
• 19. Kario K, McEwen BS, Pickering TG. Disasters and the heart: a review of the effects of earthquake-induced stress on cardiovascular disease. Hypertens Res. 2003;26(5):355-367.
• 20. Anwar J, Mpofu E, Matthews LR, Brock KE. Risk factors of posttraumatic stress disorder after an earthquake disaster. J Nerv Ment Dis. 2013;201(12):1045–52.
• 21. Ren J, Jiang X, Yao J, et al. Depression, social support, and coping styles among pregnant women after the Lushan earthquake in Ya'an, China. PLoS ONE. 2015;10(8):1–19.
• 22. Gluckman PD, Hanson MA, Cooper C, Thornburg KL. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med. 2008;359(1):61-73.
• 23. Li N, Wang Y, Yu L, et al. Long-term effects of earthquake experience of young persons on cardiovascular disease risk factors. Arch Med Sci: AMS. 2017;13(1):75-81.
• 24. Hales CN, Barker DJ. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia. 1992;35(7):595-601.
• 25. Hochberg Z, Feil R, Constancia M, et al. Child health, developmental plasticity, and epigenetic programming. Endocr Rev. 2011;32(2):159-224.
• 26. Mastrolia SA, Cetin I. (2020). The “Great Obstetrical Syndromes”. In: Petraglia F, Fauser B. (eds) Female Reproductive Dysfunction. Endocrinology. Springer, Cham. 2020: 411-430.
• 27. Romero R. Prenatal medicine: the child is the father of the man. 1996. J Matern Fetal Neonatal Med. 2009;22(8):636-639.
• 28. Brosens I, Pijnenborg R, Vercruysse L, Romero R. The “great obstetrical syndromes” are associated with disorders of deep placentation. Am J Obstet Gynecol. 2011;204(3):193-201.
• 29. Khong Y, Brosens I. Defective deep placentation. Best Pract Res Clin Obstet Gynaecol. 2011;25(3):301-311.
• 30. Brosens I. Morphological changes in the utero-placental bed in pregnancy hyptertension. Clin Obstet Gynaecol. 1977;4(3):573-93.
• 31. Aardema MW, Oosterhof H, Timmer A, Van Rooy I, Aarnoudse JG. Uterine artery Doppler flow and uteroplacental vascular pathology in normal pregnancies and pregnancies complicated by pre-eclampsia and small for gestational age fetuses. Placenta. 2001;22:405–411.
• 32. Espinoza J, Romero R, Yeon MK, et al. Normal and abnormal transformation of the spiral arteries during pregnancy. J Perinat Med. 2006;34:447–458.
• 33. Haig D. Maternal-fetal interactions and MHC polymorphism. J Reprod Immunol. 1997;35(2):101–109.
• 34. Goddard KA, Tromp G, Romero R, et al. Candidate-gene association study of mothers with pre-eclampsia, and their infants, analyzing 775 SNPs in 190 genes. Hum Hered. 2007;63(1):1–16.
• 35. Parimi N, Tromp G, Kuivaniemi H, et al. Analytical approaches to detect maternal/fetal genotype incompatibilities that increase risk of pre-eclampsia. BMC Med Genet. 2008;9:60.
• 36. Wadhwa PD, Culhane JF, Rauh V, Barve SS. Stress and preterm birth: neuroendocrine, immune/inflammatory, and vascular mechanisms. Matern Child Health J. 2001;5(2):119-25.
• 37. Torche F. The Effect of Maternal Stress on Birth Outcomes: Exploiting a Natural Experiment. Demography. 2011;48(4):1473-91.
• 38. Doğer E, Cakıroğlu Y, Köpük SY, Ceylan Y, Simşek HU, Calışkan E. Impact of earthquakes on sex ratio at birth: Eastern Marmara earthquakes, J Turk Ger Gynecol Assoc. 2013;14(2):92–97.
• 39. Fukuda M, Fukuda K, Shimizu T, Møller H. Decline in sex ratio at birth after Kobe earthquake. Hum Reprod. 1998;13: 2321–2322.
• 40. Fukuda M, Fukuda K, Mason S, Shimizu T, Andersen CY. Effects of earthquakes and other natural catastrophic events on the sex ratio of newborn infants, Early Human Development. 2020;140:104859.
• 41. Taylor KC, Jackson LW, Lynch CD, Kostyniak PJ, Buck Louis GM. Preconception maternal polychlorinated biphenyl concentrations and the secondary sex ratio. Environ Res. 2007;103:99–105.