Phytochemical Analysis of Polygonum bistorta L. Subsp. Carneum (Koch): Quantitative Analysis of Phenolics, Silver Nanoparticles Synthesis, and Biological Activity

Abstract

Natural products are significant for food and pharmaceuticals due to their biological effects. The improvement of spectroscopy led to the isolation of bioactive compounds from plants and other organisms, and these compounds have been effectively used as raw pharmaceutical materials. Herein, bioactive compounds in Polygonum bistorta subsp. corneum aerial part was determined quantitatively by LC-MS/MS. Shikimic acid (mg/g extract) (2.85), catechin (1.88), chlorogenic acid (0.534), quercetin-3-D-xyloside (0.439), and hesperidin (0.355) were found as major products. The aerial part of this plant was employed for silver nanoparticles (AgNPs) synthesis. The aerial of the plant material was heated in deionized water for 2 hours, then filtrated. The filtrate was treated with AgNO3 (1.0 mM) to yield the AgNPs. Advanced spectroscopic and image techniques such as XRD, UV-Vis, Zetasizer, FTIR, and TEM were employed to identify the structure. The particle size of AgNPs was determined as 21.3 nm. DPPH assay and ABTS assay were exploited. AgNPs demonstrated better antioxidant activity than extract.

Keywords

• Silver nanoparticles
• green synthesis
• Polygonum bistorta subsp. carneum
• spectroscopy
• natural products

References

1. REFERENCES
2. 1. Topçu, G.; Erenler, R.; Çakmak, O.; Johansson, C. B.; Çelik, C.; Chai, H.-B.; Pezzuto, J. M. Phytochemistry 1999, 50 (7), 1195-1199.
3. 2. Elmastas, M.; Ozturk, L.; Gokce, I.; Erenler, R.; Aboul‐Enein, H. Y. Anal Lett 2004, 37 (9), 1859-1869.
4. 3. Demirtas, I.; Erenler, R.; Elmastas, M.; Goktasoglu, A. Food Chem 2013, 136 (1), 34-40.
5. 4. Newman, D. J.; Cragg, G. M. J Nat Prod 2007, 70 (3), 461-477.
6. 5. Erenler, R.; Biellmann, J. F. Tetrahedron Lett 2005, 46 (34), 5683-5685.
7. 6. Cakmak, O.; Erenler, R.; Tutar, A.; Celik, N. J Org Chem 2006, 71 (5), 1795-1801.
8. 7. Erenler, R.; Demirtas, I.; Buyukkidan, B.; Cakmak, O. J Chem Res 2006, (12), 753-757.

9. 8. Erenler, R.; Biellmann, J. F. J Chin Chem Soc 2007, 54 (1), 103-108.
10. 9. Lu, J.; Maezawa, I.; Weerasekara, S.; Erenler, R.; Nguyen, T. D. T.; Nguyen, J.; Swisher, L. Z.; Li, J.; Jin, L. W.; Ranjan, A.; Srivastava, S. K.; Hua, D. H. Bioorgan Med Chem lett 2014, 24 (15), 3392-3397.
11. 10. Cragg, G. M.; Newman, D. J.; Snader, K. M. J Nat Prod 1997, 60 (1), 52-60.
12. 11. Erenler, R.; Gecer, E. N.; Genc, N.; Yanar, D. Int J Chem Technol 2021, 5 (2), 141-146.
13. 12. Gecer, E. N. J Inorg Organomet Polym Mater 2021, 31 (11), 4402-4409.
14. 13. Seçme, A.; Bozer, B. M.; Kocaman, A. Y.; Erenler, R.; Calimli, M. H. J Drug Deliv Technol 2024, 105478.
15. 14. Genc, N. Particul Sci Technol 2021, 39 (5), 562-568.
16. 15. Genc, N.; Yildiz, I.; Chaoui, R.; Erenler, R.; Temiz, C.; Elmastas, M. Inorg Nano-Met Chem 2021, 51 (3), 411-419.
17. 16. Dag, B. Particul Sci Technol 2022, 40 (4), 512-520.
18. 17. Erenler, R.; Dag, B. Inorg Nano-Met Chem 2022, 52 (4), 485-492.
19. 18. Erenler, R.; Gecer, E. N. Turk J Agricul Food Sci Tech 2022, 10 (6), 1112-1115.
20. 19. Erenler, R.; Gecer, E. N. J Nano Res 2022, 75, 17-28.
21. 20. Gecer, E. N.; Erenler, R. Turk J Biodiv 2022, 5 (1), 50-56.
22. 21. Gecer, E. N.; Erenler, R. J Chem Soc Pakistan 2022, 44 (6), 610-617.
23. 22. Gecer, E. N.; Erenler, R.; Temiz, C.; Genc, N.; Yildiz, I. Particul Sci Technol 2022, 40 (1), 50-57.
24. 23. Sun, X.-B.; Zhao, P.-H.; Xu, Y.-J.; Sun, L.-M.; Cao, M.-A.; Yuan, C.-S. Chem Nat Compd 2007, 43, 563-566.
25. 24. Atalar, M. N.; Erenler, R.; Turkan, F.; Alma, M. H.; Demirtas, I.; Baran, A.; Kandemir, S. I.; Kekec, A. I.; Saltan, F. Z. Eur J Integr Med 2023, 62, 102290.
26. 25. Erenler, R.; Atalar, M. N.; Yıldız, İ.; Geçer, E. N.; Yıldırım, A.; Demirtas, İ.; Alma, M. H. Bütünleyici ve Anadolu Tıbbı Dergisi 2023, 4 (3), 3-10.
27. 26. Erenler, R.; Telci, I.; Ulutas, M.; Demirtas, I.; Gul, F.; Elmastas, M.; Kayir, O. J Food Biochem 2015, 39 (5), 622-630.
28. 27. Erenler, R.; Demirtas, I.; Karan, T.; Gul, F.; Kayir, O.; Karakoc, O. C. Trends Phytochem Res 2018, 2 (2), 91-96.
29. 28. Erenler, R.; Telci, İ.; Elmastaş, M.; Akşit, H.; Gül, F.; Tüfekçi, A. R.; Demirtaş, İ.; Kayir, Ö. Turk J Chem 2018, 42 (6), 1695-1705.
30. 29. Genç, N.; Elmastaş, M.; Telci, İ.; Erenler, R. Int J Chem Technol 2020, 4 (2), 179-184.
31. 30. Erenler, R.; Geçer, E. N.; Alma, M. H.; Demirtas, İ. J Integ Ana Med 2022, 4 (1), 15-20.
32. 31. Yaman, C.; Önlü, Ş.; Ahmed, H.; Erenler, R. J Anim Plant Sci 2022, 32 (2), 596-603.
33. 32. Erenler, R.; Yilmaz, S.; Aksit, H.; Sen, O.; Genc, N.; Elmastas, M.; Demirtas, I. Rec Nat Prod 2014, 8 (1), 32-36.
34. 33. Elmastaş, M.; Telci, İ.; Akşit, H.; Erenler, R. Turk J Biochem 2015, 40 (6), 456-462.
35. 34. Elmastas, M.; Erenler, R.; Isnac, B.; Aksit, H.; Sen, O.; Genc, N.; Demirtas, I. Nat Prod Res 2016, 30 (3), 299-304.
36. 35. Erenler, R.; Sen, O.; Aksit, H.; Demirtas, I.; Yaglioglu, A. S.; Elmastas, M.; Telci, İ. J Sci Food Agr 2016, 96 (3), 822-836.
37. 36. Erenler, R.; Adak, T.; Karan, T.; Elmastas, M.; Yildiz, I.; Aksit, H.; Topcu, G.; Sanda, M. A. The Eurasia Proceed Sci Tech Eng Math 2017, 1, 139-145.
38. 37. Erenler, R.; Meral, B.; Sen, O.; Elmastas, M.; Aydin, A.; Eminagaoglu, O.; Topcu, G. Pharm Biol 2017, 55 (1), 1646-1653.
39. 38. Karan, T.; Erenler, R.; Bozer Moran, B. Z Naturforsch C J Biosci 2022, 77 (7-8), 343-350.
40. 39. Sahin Yaglioglu, A.; Erenler, R.; Gecer, E. N.; Genc, N. J Inorg Organomet Polym Mater 2022, 32, 3700-3707.
41. 40. Erenler, R.; Yaman, C.; Demirtas, I.; Alma, M. H. Nat Prod J 2023, 13 (7), e120123212672.
42. 41. Karan, Y. B.; Erenler, R. Communications in Soil Science and Plant Analysis 2024, 1-9.
43. 42. Yaman, C.; Erenler, R.; Atalar, M. N.; Adem, Ş.; Çalişkan, U. K. Brazilian Archives of Biology and Technology 2024, 67, e24230043.
44. 43. Batory, M.; Rotsztejn, H. Journal of Cosmetic Dermatology 2022, 21 (2), 501-505.
45. 44. Ganeshpurkar, A.; Saluja, A. Indian Journal of Biochemistry and Biophysics (IJBB) 2020, 57 (5), 505-511.
46. 45. Suvith, V.; Philip, D. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2014, 118, 526-532.
47. 46. Houari, F. Z.; Brahmi, M.; Erenler, R.; Hariri, A. Nat Prod Res 2024, 165-174.
48. 47. Nayel, N.; Marah, S.; Ozen, T.; Yıldız, I.; Erenler, R.; Behcet, L. BioNanoScience 2024.
49. 48. Waris, A.; Din, M.; Ali, A.; Afridi, S.; Baset, A.; Khan, A. U.; Ali, M. Open Life Sci 2021, 16 (1), 14-30.