Toxicological Evaluation of Aqueous Stem Bark Extract of Guiera senegalensis on Wistar Rats

Year 2022, , 45 - 51, 04.04.2022

Maryam Usman Ahmed Diowato Titus , Isaac John Umaru

https://doi.org/10.53811/ijtcmr.1060996

Cited By: 1

Abstract

Objective: Global herbal products howbeit have enormous potential as natural drugs and are of vast commercial significance, are often processed and procured without being scientifically evaluated for their toxicity. This study evaluated the toxicological effects of Guiera senegalensis on wistar rats.
Method: An acute toxicity was carried out to determine the LD50 of Guiera senegalensis stem bark extract. Sub-acute toxicity was carried out to determine the effect of the plant extract on some liver and kidney function parameters and haematological parameters. Twenty (20) rats were ramdomly placed into 4 groups of 5 rats. Group 2, 3 and 4 were orally treated with aqueous stem bark extract of Guiera senegalensis at a daily dose of 200, 400 and 800 mg/kg body weight (b.wt.) respectively for 28 days while group 1 served as a control group.
Results: ALT, AST, ALP and bilirubin levels increased significantly as dose increases. No significant increase in K+ and urea was observed in group 2 and 3 treated with 200 mg/kg and 400 mg/kg respectively. However, significant increase was observed in group 4 treated with 800 mg/kg. Na+ and Creatinine showed significant increase when compared with control group. RBC, PCV, and Hb decreased significantly whereas a significant increase was observed in WBC with increase in dose respectively.
Conclusion: The aqueous stem bark extract of Guiera senegalensis have a dose-dependent toxic effect on liver, kidney and haematology of wistar rats.
Key words: Toxicological Evaluation, Guiera Senegalensis, Liver, Kidney, Haematological parameters

Keywords

Toxicological Evaluation, Guiera Senegalensis, Liver, Kidney, Haematological parameters

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