Nörotoksik Kemoterapi Alan Kadınlarda Periferal Nöropati Şiddeti ile Ağrı ve Yaşam Kalitesinin Belirlenmesi

Abstract

Amaç: Bu çalışma, nörotoksik kemoterapi alan kadınlarda periferal nöropati şiddeti ile ağrı ve yaşam kalitesi düzeylerinin belirlenmesi amacıyla yapılmıştır. Gereç ve Yöntem: Tanımlayıcı türdeki bu araştırmanın örneklemi Şubat-Ağustos 2023 tarihleri arasında Gülhane Eğitim ve Araştırma Hastanesi, Kemoterapi Ünitesinde nörotoksik kemoterapi ilaçlarından en az bir tanesini alan, en az 3 kür kemoterapi almış olan, grade 1 ve üzeri periferal nöropatisi olan, 18-65 yaş aralığında olan, Türkçe bilen, çalışmaya katılmayı kabul eden 152 kadın hastadan oluşmuştur. Araştırma verileri, tanıtıcı bilgi formu, ağrı ve nöropati değerlendirme formu, kanser hastalarının yaşam kalitesini değerlendirme formu ve kemoterapiye bağlı periferik nöropati değerlendirme formu kullanılarak toplanmıştır. Bulgular: Çalışmamızda kemoterapiye bağlı periferal nöropatinin yaşam kalitesi olumsuz etkilediği, kadınların %76,65’inin ağrı semptomu yaşadığı, %77,6’sında grade 1 periferal nöropati görüldüğü belirlenmiştir. Grade 2 nöropatisi olan hastaların nöropati şiddetine göre yaşam kalitesi puanlarında fiziksel, rol ve emosyonel fonksiyon ortalama puanları daha düşüktür (p<0,05). Grade 2 nöropatisi olan hastaların semptom skalası alt boyutlarında bulantı, ağrı ve yorgunluk puanları daha yüksektir. Kemoterapiye bağlı periferik nöropati ölçeği alt boyutları değerlendirildiğinde, grade 2 nöropatisi olan hastalarda motor fonksiyon ve duyusal fonksiyon ortalama puanları daha yüksek belirlenmiştir (p<0,05). Sonuç: Araştırma sonucunda elde edilen bulgular nörotoksik kemoterapi alan kadınlarda ağrı ve yaşam kalitesinin çok yönlü bir sorun olduğunu ve etkili yönetimi için multidisipliner bir yaklaşım gerektirdiğini göstermektedir. Nörotoksik kemoterapi alan hastalara danışmanlık yapan onkoloji hemşirelerinin semptom yönetimi ve değerlendirmelerini tedavinin başında, sürecinde ve sonrasında düzenli olarak yapması önerilir.

Keywords

• Periferal nöropati
• ağrı
• yaşam kalitesi
• hemşirelik

Determination of Peripheral Neuropathy Severity and Pain and Quality of Life in Women Receiving Neurotoxic Chemotherapy

Abstract

Objective: This study aimed to assess the levels of peripheral neuropathy severity and pain and quality of life in women undergoing neurotoxic chemotherapy. Material and Methods: This descriptive study involved 152 female patients who received at least one neurotoxic chemotherapy drugs at the Chemotherapy Unit of Gülhane Training and Research Hospital between February and August 2023, who received at least three cycles of chemotherapy, who had grade 1 and above peripheral neuropathy, were between the ages of 18-65, spoke Turkish, and agreed to participate in the study. Data were collected using the introductory information form, pain and neuropathy evaluation form, quality of life assessment form for cancer patients, and chemotherapy-induced peripheral neuropathy questionnaires. Results: The study found that chemotherapy-induced peripheral neuropathy significantly impacted quality of life, with 76.65% of participants experiencing pain. Additionally, 77.6% of participants had grade 1 peripheral neuropathy. Women with grade 2 neuropathy had lower physical, role, and emotional function scores compared to those with lower neuropathy severity (p<0.05). They also had higher scores for nausea, pain, and fatigue in the symptom sub-dimensions. Furthermore, grade 2 neuropathy patients had higher motor and sensory function scores on the chemotherapy-induced peripheral neuropathy scale (p<0.05). Conclusion: The findings obtained as a result of the study show that pain and quality of life in women receiving neurotoxic chemotherapy are multifaceted problems and require a multidisciplinary approach for effective management. Oncology nurses should regularly assess patients for chemotherapy-induced peripheral neuropathy throughout treatment and guide symptom management.

Keywords

• Peripheral neuropathy
• pain
• quality of life
• nursing

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