Bağırsak Mikrobiyotası ve Obezite İlişkisi

Abstract

ÖZET

Bağırsak Mikrobiyotası ve Obezite İlişkisi

Obezite, kanser de dahil olmak üzere kronik hastalık riskinin artması gibi sağlık açısından risk arz eden ve zaman içinde sürekli pozitif enerji dengesinin sonucu oluşan aşırı adipozite hali olarak tanımlanmaktadır. Bu hastalığın önlenmesindeki çevresel faktörler; stresi azaltmak, BKİ’yi düşürmek, yeterli ve dengeli beslenmek ve intestinal mikrobiyotadır. Bu derlemede amaç, intestinal mikrobiyotanın obezite üzerindeki etki mekanizmaları hakkında bilgi vermektir. Bulgular arasında LPS ile TLR-4 reseptörü arasındaki etkileşim, NF-KB yolunu aktive ederek mukozal inflamasyonu ve bakteriyel translokasyonu aktive eder. Bunun sonucunda endojen inflamatuar mediatörler olarak çalışan TNF-α, IL-1, IL-6, IL-8 ve IL-12 gibi pro-inflamatuar sitokinlerin sentezi indüklenir. Sonuç olarak obeziteye neden olan sağlıksız beslenme, sedanter yaşam, çeşitli hastalıklar (diyabet, depresyon) gibi faktörlere son yıllarda mikrobiyotada oluşan olumsuz değişiklerin de eklendiği görülmektedir.

Anahtar Kelimeler: Obezite, Mikrobiyota, Diyet

                                                                        

ABSTRACT

The Relationship between Intestinal Microbiota and Obesity

Obesity is defined as a state of extreme adiposity, which is a risk to health, such as an increased risk of chronic disease, including cancer, that results from a continuous positive energy balance over time. Environmental factors in the prevention of this disease; to reduce stress, reduce BMI, adequate and balanced nutrition and intestinal microbiota. The aim of this review is to give information about the mechanisms of action of intestinal microbiota on obesity. Among the findings, the interaction between LPS and TLR-4 receptor activates the NF-yolB pathway and activates mucosal inflammation and bacterial translocation. As a result, synthesis of pro-inflammatory cytokines such as TNF-α, IL-1, IL-6, IL-8 and IL-12, which act as endogenous inflammatory mediators, are induced. As a result, it is seen that negative changes in microbiota have been added to factors such as unhealthy nutrition, sedentary life, various diseases (diabetes, depression) that cause obesity.

Key Words: Obesity, Microbiota, Diet

 

Keywords

• Obezite,Mikrobiyota,Diyet

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