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Obezite ve COVID-19

Year 2020, Volume: 5 Issue: 2, 211 - 214, 30.06.2020

Abstract

Özet


Şiddetli Akut Solunum Sendromu Koronavirüs-2 (SARS-CoV-2), Dünya Sağlık Örgütü (DSÖ) tarafından Koronavirus Hastalığı 2019 (COVID-19) olarak adlandırılan hastalığın etkeni olan yeni tip koronavirüstür. İlk olarak Çin’in Wuhan şehrinde ortaya çıkmış ve tüm dünyaya hızla yayılmıştır. İnsandan insana çok hızlı bulaşabilen COVID-19, yaş ile ilişkili olmakla birlikte hipertansiyon, diyabet, kardiyovasküler hastalıklar vb. komorbiditesi olan bireylerde daha şiddetli seyretmektedir. Günümüzün önemli bir halk sağlığı sorunu olan obezite; bulaşıcı olmayan kronik hastalıkların oluşma riskini arttırmakta ve solunum yolu hastalıklarının gelişmesine neden olmaktadır. Obezite ile COVID-19 arasındaki ilişkiyi ortaya koyacak mekanizma net olarak bilinmemesine rağmen yapılan çalışmalarla, vücut ağırlığındaki artışın COVID-19 enfeksiyonu şiddetini de arttığını gösterilmiştir. Sonuç olarak tüm dünyada ve ülkemizde önemli bir sağlık sorunu olan COVID-19 hastalığının tedavisinde; diyabet, hipertansiyon vb hastalıkların yanı sıra hastalığın seyrinin hafifletilmesi ve yoğun bakımdaki hasta sayısının ve kalış süresinin azaltılması amacıyla obeziteye de dikkat edilmesi gerekmektedir. Bu derlemede obezite ve COVID-19 arasındaki ilişki ve olası mekanizmalar tartışılmıştır.


Anahtar Kelimeler: Obezite, beden kütle indeksi, COVID-19, inflamasyon.


Abstract


Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), a new type of coronavirus which is the cause of disease named the Coronavirus Disease 2019 (COVID-19) by the World Health Organization (WHO), first appeared in Wuhan, China and spread all over the world rapidly. COVID-19, which can be transmitted rapidly from person to person, is age-related; however, it is more severe in people with comorbidities such as hypertension, diabetes, cardiovascular disease, etc. Being one of the serious health issues today, obesity increases the risk of non-communicable diseases and causes the development of respiratory diseases. Although the mechanism between obesity and COVID-19 is not clearly known, studies have shown that the increase in body weight is positively associated with the severity of COVID-19 infection, the need for treatment in the intensive care unit, and the rates of mechanical ventilation. Consequently, obesity should be considered in the prevention and treatment of COVID-19 disease, which is a critical health issue across the world and in our country, in addition to chronic diseases, to reduce the course of the disease and complications. In this study, the relationship and possible mechanisms between obesity and COVID-19 are discussed.


Keywords: Obesity, body mass index, COVID-19, inflammation.

References

  • Bornstein, S. R., Dalan, R., Hopkins, D., Mingrone, G., Boehm, B. O. (2020). Endocrine and metabolic link to coronavirus infection. Nature Reviews Endocrinology, 16(6), 297–298.
  • Cai, Q., Chen, F., Wang, T., Luo, F., Liu, X., Wu, Q. (2020b). Obesity and COVID-19 severity in a designated hospital in shenzhen, China. Preprints with The Lancet. https://papers.ssrn.com/sol3/papers. cfm?abstract_id=3556658&fbclid=IwAR1d8yXcTO6l7lgAbw_ eSidmXdtmtJyVLXWr3NuTL3G9FwkODpFrkKeeO40.
  • Cai, Q., Huang, D., Ou, P., Yu, H., Zhu, Z., Xia, Z., et al. (2020a). COVID-19 in a designated infectious diseases hospital outside Hubei Province, China. Allergy, doi.org/10.1111/all.14309
  • Caspard, H., Jabbour, S., Hammar, N., Fenici, P., Sheehan, J. J., Kosiborod, M. (2018). Recent trends in the prevalence of type 2 diabetes and the association with abdominal obesity lead to growing health disparities in the USA: An analysis of the NHANES surveys from 1999 to 2014. Diabetes, Obesity and Metabolism, 20(3), 667‐671.
  • De Rosa, V., Procaccini, C., La Cava, A., Chieffi, P., Nicoletti, G. F., Fontana, S., et al. (2006). Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis. The Journal of Clinical Investigation, 116(2), 447–455.
  • FDA Guidance on Conduct of Clinical Trials of Medical Products during COVID-19 Pandemic. Retrieved May 10. 2020, http://www.klinikarastirmalar.org/upload/documents/Clinical-Trial-Conductduring- COVID-19-Direct-to-Final-3-17-20.pdf.
  • Green, W. D., & Beck, M. A. (2017). Obesity Impairs the Adaptive Immune Response to Influenza Virus. Annals of the American Thoracic Society, 14(5), 406–409.
  • Iacobellis, G. (2020). COVID-19 and diabetes: Can DPP4 inhibition play a role?. Diabetes Research and Clinical Practice, 162, 108125.
  • Kılıç, T. (2010). Obezite ile iliskili oksidatif stresin altinda yatan mekanizmalar: Leptin ve adiponektinin rolü. Anadolu Kardiyoloji Dergisi, 10(5), 397-9.
  • Lighter, J., Phillips, M., Hochman, S., Sterling, S., Johnson, D., Francois, F., et al. (2020). Obesity in patients younger than 60 years is a risk factor for COVID-19 hospital admission. Clinical İnfectious Diseases:An Official Publication of The Infectious Diseases Society of America, ciaa415.
  • Mahase E. (2020). COVID-19: most patients require mechanical ventilation in first 24 hours of critical care. British Medical Journal (Clinical research ed.), 368, m1201.
  • Morgan, O. W., Bramley, A., Fowlkes, A., Freedman, D.S., Taylor, T. H., Gargiullo, P., et al. (2010). Morbid obesity as a risk factor for hospitalization and death due to 2009 pandemic influenza A(H1N1) disease. PloS One, 5(3), e9694.
  • O’Hara, A. M., & Shanahan, F. (2006). The gut flora as a forgotten organ. European Molecular Biology Organization Reports, 7(7), 688–693.
  • Özbalcı, D., Şahin, M. (2009). Leptin ve immün sistem. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi, 14 (2) , 51-55
  • Petrakis, D., Margină, D., Tsarouhas, K., Tekos, F., Stan, M., Nikitovic, D., et al. (2020). Obesity ‑ a risk factor for increased COVID‑19 prevalence, severity and lethality (Review). Molecular Medicine Reports, 22(1), 9-19.
  • Petrilli, C. M., Jones, S. A., Yang, J., O’Donnell, L. F., Chernyak, Y., Tobin, K., et al. (2020). Factors associated with hospitalization and critical illness among 4,103 patients with COVID-19 disease in New York City. British Medical Journal, 369, m1966.
  • Simonnet, A., Chetboun, M., Poissy, J., Raverdy, V., Noulette, J., Duhamel, A., et al. (2020). High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation. Obesity (Silver Spring), 10.1002/ oby.22831.
  • Sohrabi, C., Alsafi, Z., O’Neill, N., Khan, M., Kerwan, A., Al-Jabir, A., et al. (2020). World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19). International Journal of Surgery (London, England), 76, 71–76.
  • Sun, Y., Wang, Q., Yang, G., Lin, C., Zhang, Y., Yang, P. (2016). Weight and prognosis for influenza A(H1N1)pdm09 infection during the pandemic period between 2009 and 2011: a systematic review of observational studies with meta-analysis. Infectious Diseases (London, England), 48(11-12), 813–822.
  • Tekin, T., Çiçek, B., Konyalıgil, N. (2018). İntestinal mikrobiyota ve obezite ilişkisi. Sağlık Bilimleri Dergisi, 27(1) , 95-99.
  • Türkiye Beslenme ve Sağlık Araştırması 2010 (TBSA) (2014). https:// hsgm.saglik.gov.tr/depo/birimler/saglikli-beslenme-hareketlihayat- db/Yayinlar/kitaplar/diger-kitaplar/TBSA-Beslenme-Yayini. pdf. Erişim Tarihi: 11.05.2020.
  • Wang, B. & Trayhurn, P. (2006). Acute and prolonged effects of TNFalpha on the expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture. European Journal of Physiology, 452(4), 418–427.
  • WHO/FAO. Diet, nutrition and the prevention of chronic diseases. WHO, Geneva, 2003. Retrieved April 20. 2020, https://www.who. int/dietphysicalactivity/publications/trs916/en/.
  • World Health Organization (WHO). Obesity and Overweight Fact Sheet No:311, updated. Geneva; 2018. Retrived April 15. 2020, http:// www.who.int/mediacentre/factsheets/fs311/en/.
  • Zheng, K. I., Gao, F., Wang, X. B., Sun, Q. F., Pan, K. H., Wang, T. Y., et al. (2020). Obesity Is a Risk Factor for Greater COVID-19 Severity. Diabetes Care, 2020.
Year 2020, Volume: 5 Issue: 2, 211 - 214, 30.06.2020

Abstract

References

  • Bornstein, S. R., Dalan, R., Hopkins, D., Mingrone, G., Boehm, B. O. (2020). Endocrine and metabolic link to coronavirus infection. Nature Reviews Endocrinology, 16(6), 297–298.
  • Cai, Q., Chen, F., Wang, T., Luo, F., Liu, X., Wu, Q. (2020b). Obesity and COVID-19 severity in a designated hospital in shenzhen, China. Preprints with The Lancet. https://papers.ssrn.com/sol3/papers. cfm?abstract_id=3556658&fbclid=IwAR1d8yXcTO6l7lgAbw_ eSidmXdtmtJyVLXWr3NuTL3G9FwkODpFrkKeeO40.
  • Cai, Q., Huang, D., Ou, P., Yu, H., Zhu, Z., Xia, Z., et al. (2020a). COVID-19 in a designated infectious diseases hospital outside Hubei Province, China. Allergy, doi.org/10.1111/all.14309
  • Caspard, H., Jabbour, S., Hammar, N., Fenici, P., Sheehan, J. J., Kosiborod, M. (2018). Recent trends in the prevalence of type 2 diabetes and the association with abdominal obesity lead to growing health disparities in the USA: An analysis of the NHANES surveys from 1999 to 2014. Diabetes, Obesity and Metabolism, 20(3), 667‐671.
  • De Rosa, V., Procaccini, C., La Cava, A., Chieffi, P., Nicoletti, G. F., Fontana, S., et al. (2006). Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis. The Journal of Clinical Investigation, 116(2), 447–455.
  • FDA Guidance on Conduct of Clinical Trials of Medical Products during COVID-19 Pandemic. Retrieved May 10. 2020, http://www.klinikarastirmalar.org/upload/documents/Clinical-Trial-Conductduring- COVID-19-Direct-to-Final-3-17-20.pdf.
  • Green, W. D., & Beck, M. A. (2017). Obesity Impairs the Adaptive Immune Response to Influenza Virus. Annals of the American Thoracic Society, 14(5), 406–409.
  • Iacobellis, G. (2020). COVID-19 and diabetes: Can DPP4 inhibition play a role?. Diabetes Research and Clinical Practice, 162, 108125.
  • Kılıç, T. (2010). Obezite ile iliskili oksidatif stresin altinda yatan mekanizmalar: Leptin ve adiponektinin rolü. Anadolu Kardiyoloji Dergisi, 10(5), 397-9.
  • Lighter, J., Phillips, M., Hochman, S., Sterling, S., Johnson, D., Francois, F., et al. (2020). Obesity in patients younger than 60 years is a risk factor for COVID-19 hospital admission. Clinical İnfectious Diseases:An Official Publication of The Infectious Diseases Society of America, ciaa415.
  • Mahase E. (2020). COVID-19: most patients require mechanical ventilation in first 24 hours of critical care. British Medical Journal (Clinical research ed.), 368, m1201.
  • Morgan, O. W., Bramley, A., Fowlkes, A., Freedman, D.S., Taylor, T. H., Gargiullo, P., et al. (2010). Morbid obesity as a risk factor for hospitalization and death due to 2009 pandemic influenza A(H1N1) disease. PloS One, 5(3), e9694.
  • O’Hara, A. M., & Shanahan, F. (2006). The gut flora as a forgotten organ. European Molecular Biology Organization Reports, 7(7), 688–693.
  • Özbalcı, D., Şahin, M. (2009). Leptin ve immün sistem. Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi, 14 (2) , 51-55
  • Petrakis, D., Margină, D., Tsarouhas, K., Tekos, F., Stan, M., Nikitovic, D., et al. (2020). Obesity ‑ a risk factor for increased COVID‑19 prevalence, severity and lethality (Review). Molecular Medicine Reports, 22(1), 9-19.
  • Petrilli, C. M., Jones, S. A., Yang, J., O’Donnell, L. F., Chernyak, Y., Tobin, K., et al. (2020). Factors associated with hospitalization and critical illness among 4,103 patients with COVID-19 disease in New York City. British Medical Journal, 369, m1966.
  • Simonnet, A., Chetboun, M., Poissy, J., Raverdy, V., Noulette, J., Duhamel, A., et al. (2020). High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation. Obesity (Silver Spring), 10.1002/ oby.22831.
  • Sohrabi, C., Alsafi, Z., O’Neill, N., Khan, M., Kerwan, A., Al-Jabir, A., et al. (2020). World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19). International Journal of Surgery (London, England), 76, 71–76.
  • Sun, Y., Wang, Q., Yang, G., Lin, C., Zhang, Y., Yang, P. (2016). Weight and prognosis for influenza A(H1N1)pdm09 infection during the pandemic period between 2009 and 2011: a systematic review of observational studies with meta-analysis. Infectious Diseases (London, England), 48(11-12), 813–822.
  • Tekin, T., Çiçek, B., Konyalıgil, N. (2018). İntestinal mikrobiyota ve obezite ilişkisi. Sağlık Bilimleri Dergisi, 27(1) , 95-99.
  • Türkiye Beslenme ve Sağlık Araştırması 2010 (TBSA) (2014). https:// hsgm.saglik.gov.tr/depo/birimler/saglikli-beslenme-hareketlihayat- db/Yayinlar/kitaplar/diger-kitaplar/TBSA-Beslenme-Yayini. pdf. Erişim Tarihi: 11.05.2020.
  • Wang, B. & Trayhurn, P. (2006). Acute and prolonged effects of TNFalpha on the expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture. European Journal of Physiology, 452(4), 418–427.
  • WHO/FAO. Diet, nutrition and the prevention of chronic diseases. WHO, Geneva, 2003. Retrieved April 20. 2020, https://www.who. int/dietphysicalactivity/publications/trs916/en/.
  • World Health Organization (WHO). Obesity and Overweight Fact Sheet No:311, updated. Geneva; 2018. Retrived April 15. 2020, http:// www.who.int/mediacentre/factsheets/fs311/en/.
  • Zheng, K. I., Gao, F., Wang, X. B., Sun, Q. F., Pan, K. H., Wang, T. Y., et al. (2020). Obesity Is a Risk Factor for Greater COVID-19 Severity. Diabetes Care, 2020.
There are 25 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Derlemeler
Authors

Beda Özalp 0000-0002-7923-842X

Nilgün Seremet Kürklü 0000-0003-1394-0037

Publication Date June 30, 2020
Submission Date June 5, 2020
Published in Issue Year 2020 Volume: 5 Issue: 2

Cite

APA Özalp, B., & Seremet Kürklü, N. (2020). Obezite ve COVID-19. İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi, 5(2), 211-214.
AMA Özalp B, Seremet Kürklü N. Obezite ve COVID-19. İKÇÜSBFD. June 2020;5(2):211-214.
Chicago Özalp, Beda, and Nilgün Seremet Kürklü. “Obezite Ve COVID-19”. İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi 5, no. 2 (June 2020): 211-14.
EndNote Özalp B, Seremet Kürklü N (June 1, 2020) Obezite ve COVID-19. İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi 5 2 211–214.
IEEE B. Özalp and N. Seremet Kürklü, “Obezite ve COVID-19”, İKÇÜSBFD, vol. 5, no. 2, pp. 211–214, 2020.
ISNAD Özalp, Beda - Seremet Kürklü, Nilgün. “Obezite Ve COVID-19”. İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi 5/2 (June 2020), 211-214.
JAMA Özalp B, Seremet Kürklü N. Obezite ve COVID-19. İKÇÜSBFD. 2020;5:211–214.
MLA Özalp, Beda and Nilgün Seremet Kürklü. “Obezite Ve COVID-19”. İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi, vol. 5, no. 2, 2020, pp. 211-4.
Vancouver Özalp B, Seremet Kürklü N. Obezite ve COVID-19. İKÇÜSBFD. 2020;5(2):211-4.



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