GENETIC SYNDROMES AS A CAUSE OF TREATMENT RESISTANCE IN SCHIZOPHRENIA: A CASE WITH TRIPLE X SYNDROME

Bahadır Turan; Mehmet Akif Akıncı; İbrahim Selçuk Esin; Onur Burak Dursun

doi:10.26650/IUITFD.2019.0011

Case Report

GENETIC SYNDROMES AS A CAUSE OF TREATMENT RESISTANCE IN SCHIZOPHRENIA: A CASE WITH TRIPLE X SYNDROME

Year 2019, , 162 - 163, 16.07.2019

Bahadır Turan Mehmet Akif Akıncı İbrahim Selçuk Esin , Onur Burak Dursun

https://doi.org/10.26650/IUITFD.2019.0011

Abstract

Triple X syndrome (47, XXX) is a numerical chromosomal alteration that affects 1/1.000 females, in which the individual is born with an extra X chromosome. Trisomy X is a relatively common but under- recognized chromosomal disorder associated with characteristic cognitive and behavioural features of varying severity. We report a 16-year old patient with Triple X syndrome and resistant schizophrenia. It is remarkable that genetic syndromes may be associated with resistance to treatment of psychiatric problems. Therefore in cases with treatment resistance, the genetic analysis should absolutely be examined.

Keywords

Schizophrenia, treatment resistance, Triple X syndrome

References

1. Afshan A. Triple X syndrome. J Pak Med Assoc 2012;62(4):392.
2. Woodhouse WJ, Holland AJ, McLean G, Reveley AM. The association between triple X and psychosis. Br J Psychiatry. 1992;160(4):554-7.
3. Otter M, Schrander-Stumpel CT, Curfs LM. Triple X syndrome: a review of the literature. Eur J Hum Genet. 2010;18(3):265.
4. Lenroot RK, Blumenthal JD, Wallace GL, Clasen LS, Lee NR, Giedd JN. A case-control study of brain structure and behavioral characteristics in 47, XXX syndrome. Genes Brain Behav. 2014;13(8):841-9.

ŞİZOFRENİDE TEDAVİYE DİRENÇ NEDENİ OLARAK GENETİK SENDROMLAR: TRİPLE X SENDROMLU BİR OLGU

Year 2019, , 162 - 163, 16.07.2019

Bahadır Turan Mehmet Akif Akıncı İbrahim Selçuk Esin , Onur Burak Dursun

https://doi.org/10.26650/IUITFD.2019.0011

Abstract

Amaç: Triple X sendromu (47, XXX), kadınlarda ekstra bir X kromozomunun varlığı ile karakterize, 1/1.000 kişide bir görülen bir sendromdur. Trizomi X, değişken şiddette bilişsel ve davranışsal özelliklerle karakterize bir kromozomal hastalıktır. Bu olgu sunumunda; Triple X sendromlu ve dirençli şizofreni tanısı alan 16 yaşında bir vaka sunuyoruz. Genetik sendromların psikiyatrik problemlerin tedavisinde tedaviye dirençle ilişkili olabileceği ve bu nedenle tedaviye dirençli olgularda genetik analizlerin mutlaka yapılması gerektiği göz önünde bulundurulmalıdır.

Keywords

Şizofreni, tedaviye direnç, Triple X sendrom

References

1. Afshan A. Triple X syndrome. J Pak Med Assoc 2012;62(4):392.
2. Woodhouse WJ, Holland AJ, McLean G, Reveley AM. The association between triple X and psychosis. Br J Psychiatry. 1992;160(4):554-7.
3. Otter M, Schrander-Stumpel CT, Curfs LM. Triple X syndrome: a review of the literature. Eur J Hum Genet. 2010;18(3):265.
4. Lenroot RK, Blumenthal JD, Wallace GL, Clasen LS, Lee NR, Giedd JN. A case-control study of brain structure and behavioral characteristics in 47, XXX syndrome. Genes Brain Behav. 2014;13(8):841-9.

There are 4 citations in total.

Details

Primary Language	English
Subjects	Health Care Administration
Journal Section	Case Reports
Authors	Bahadır Turan This is me 0000-0003-1190-9589 Mehmet Akif Akıncı This is me 0000-0002-6436-4394 İbrahim Selçuk Esin 0000-0001-5598-2097 Onur Burak Dursun This is me 0000-0003-2990-9851
Publication Date	July 16, 2019
Submission Date	October 18, 2018
Published in Issue	Year 2019

Cite

APA	Turan, B., Akıncı, M. A., Esin, İ. S., Dursun, O. B. (2019). GENETIC SYNDROMES AS A CAUSE OF TREATMENT RESISTANCE IN SCHIZOPHRENIA: A CASE WITH TRIPLE X SYNDROME. Journal of Istanbul Faculty of Medicine, 82(3), 162-163. https://doi.org/10.26650/IUITFD.2019.0011
AMA	Turan B, Akıncı MA, Esin İS, Dursun OB. GENETIC SYNDROMES AS A CAUSE OF TREATMENT RESISTANCE IN SCHIZOPHRENIA: A CASE WITH TRIPLE X SYNDROME. İst Tıp Fak Derg. July 2019;82(3):162-163. doi:10.26650/IUITFD.2019.0011
Chicago	Turan, Bahadır, Mehmet Akif Akıncı, İbrahim Selçuk Esin, and Onur Burak Dursun. “GENETIC SYNDROMES AS A CAUSE OF TREATMENT RESISTANCE IN SCHIZOPHRENIA: A CASE WITH TRIPLE X SYNDROME”. Journal of Istanbul Faculty of Medicine 82, no. 3 (July 2019): 162-63. https://doi.org/10.26650/IUITFD.2019.0011.
EndNote	Turan B, Akıncı MA, Esin İS, Dursun OB (July 1, 2019) GENETIC SYNDROMES AS A CAUSE OF TREATMENT RESISTANCE IN SCHIZOPHRENIA: A CASE WITH TRIPLE X SYNDROME. Journal of Istanbul Faculty of Medicine 82 3 162–163.
IEEE	B. Turan, M. A. Akıncı, İ. S. Esin, and O. B. Dursun, “GENETIC SYNDROMES AS A CAUSE OF TREATMENT RESISTANCE IN SCHIZOPHRENIA: A CASE WITH TRIPLE X SYNDROME”, İst Tıp Fak Derg, vol. 82, no. 3, pp. 162–163, 2019, doi: 10.26650/IUITFD.2019.0011.
ISNAD	Turan, Bahadır et al. “GENETIC SYNDROMES AS A CAUSE OF TREATMENT RESISTANCE IN SCHIZOPHRENIA: A CASE WITH TRIPLE X SYNDROME”. Journal of Istanbul Faculty of Medicine 82/3 (July 2019), 162-163. https://doi.org/10.26650/IUITFD.2019.0011.
JAMA	Turan B, Akıncı MA, Esin İS, Dursun OB. GENETIC SYNDROMES AS A CAUSE OF TREATMENT RESISTANCE IN SCHIZOPHRENIA: A CASE WITH TRIPLE X SYNDROME. İst Tıp Fak Derg. 2019;82:162–163.
MLA	Turan, Bahadır et al. “GENETIC SYNDROMES AS A CAUSE OF TREATMENT RESISTANCE IN SCHIZOPHRENIA: A CASE WITH TRIPLE X SYNDROME”. Journal of Istanbul Faculty of Medicine, vol. 82, no. 3, 2019, pp. 162-3, doi:10.26650/IUITFD.2019.0011.
Vancouver	Turan B, Akıncı MA, Esin İS, Dursun OB. GENETIC SYNDROMES AS A CAUSE OF TREATMENT RESISTANCE IN SCHIZOPHRENIA: A CASE WITH TRIPLE X SYNDROME. İst Tıp Fak Derg. 2019;82(3):162-3.