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Mezenkimal Kök Hücre Ve Maksiilofasiyal Cerrahide Kullanımı

Year 2019, Volume: 2 Issue: 2, 86 - 94, 18.12.2019

Abstract

Özet: Kök hücreler
organizmada farklı hücre tiplerine dönüşebilen, canlı kaldıkça yaşamlarını
sürdürme özelliğine sahip ve kendi kendilerini yenileyebilen hücrelerdir.

Elde
edildiği yere göre embriyonal ve yetişkin kök hücresi olmak üzere 2 tip kök
hücre bulunmaktadır.
Embriyonal kök hücreler ile ilgili etik sınırlamalardan
dolayı çalışmalar kısıtlıdır. Mezenkimal kök hücrelerdeki çalışmalar hem elde
ediliş kolaylığı hem de rejeneratif tıpta kullanım alanı bulması ile öne
çıkmaktadır.
Son yıllardaki çalışmalarda maksillofasiyal orjinli kök
hücrelerin vücutta çok fazla hücreye diferansiye olabildiği gösterilmiştir, bu
nedenle, gelecekte sadece oral dokular değil ekstra-oral doku ve organlar için
de önemli hücre kaynakları oluşturmaları olasıdır. Bu derlemede kök hücreler,
mezenkimal kök hücreler, oral kavite kaynaklı MKH’lar ve maksillofasiyal cerrahideki
çeşitli klinik kullanım alanları yer almaktadır. 

References

  • KAYNAKLAR:1- Cheung TH, Rando TA. Molecular regulation of stem cell quiescence. Nat Rev Mol Cell Biol 2013;14:329-40.2- Martin GR. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proceedings of the National Academy of Sciences of the United States of America 1981;78:7634-8.3- Korbling M, Estrov Z. Adult stem cells for tissue repair. a new therapeutic concept? The New England Journal of Medicine 2003;349:570-82.4- Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007;318:1917-20.5- Maria OM, Khosravi R, Mezey E,Tran SD. Cells from bone marrow that evolve into oral tissues and their clinical applications.Oral Dis 2007; 13: 11-16.6- Özel BH, Ozan E, Dabak DÖ. Embriyonik Kök Hücreler. Türkiye Klinikleri J Med Sci 2008; 28: 333-341.7- Nedel F, Almeida D, Oliveria I, Mabel M, Casagrande L, Fernando F. The rapeutic potential in dentistry. J Contemp Dent Pract 2009;10(4):90-96.8- Tekeli S, Arısu Naghavi E, Gökçe B, Sır G, Yiğittürk G, Çavuşoğlu T ve ark. Kök hücreler; mezenkimal kök hücreler ve güncel klinik uygulamaları. FNG & Bilim Tıp Transplantasyon Dergisi 2016;1:72-83.9- Trounson A, McDonald C. Stem Cell Therapies in Clinical Trials: Progress and Challenges. Cell Stem Cell 2015;17:11-22.10- Kılıç KD, Başaloğlu HK, Uyanikgil Y, Turgut M.Current Topics on Cancer Stem Cell Associated Melanoma Treatment Researches. J Brain Tumors Neurooncol 2017;2:1.11- George B (2011): Regulations and guidelines governing stem cell based products: Clinical considerations. Perspect Clin Res, 2:94-9612- Gronthos S, Chen S, Wang CY, Robey PG, Shi S. Telomerase accelerates osteogenesis of bone marrow stromal stem cells by upregulation of CBFA1, osterix, and osteocalcin. J Bone Miner Res 2003;18(4):716-22.13- Stewart R, Stojkovic M, Lako M. Mechanisms of self-renewal in human embryonic stem cells. Eur J Cancer 2006;42(9):1257-72.14- Wada N, Menicanin D, Shi S, Bartold PM, Gronthos S. Immunomodulatory properties of human periodontal ligament stem cells. J Cell Physiol 2009;219(3):667-7615- da Silva Meirelles L, Chagastelles PC, Nardi NB.Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci 2006;119:220416- Hasan A, Deeb G, Rahal R, Atwi K, Mondello S, Marei HE, et al. Mesenchymal Stem Cells in the Treatment of Traumatic Brain Injury. Front Neurol 2017;8:28.17- Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999, 284(5411):143-147.18- Csaki C, Matis U, Mobasheri A, Ye H (2007):Chondrogenesis, osteogenesis and adipogenesis of canine mesenchymal stem cell: a biochemical,morphological and ultrastructural study. Histochem Cell Biol,128: 507-20.19- Kim JW, Lee JH, Lyoo YS, Jung DI, Park HM (2013) The effects of topical mesenchymal stem cell transplantation in canine experimental cutaneous wounds.Vet Dermatol, 24: 242-253.20- Pasquinelli G, Tazzari P, Ricci F, Vaselli C, Buzzi M, Conte R (2007): Ultrastructural Characteristics of Human Mesenchymal Stromal (Stem) Cells Derived from Bone Marrow and Term Placenta. Ultrastructural Pathology, 31:23-31.21- Ding DC(1), Shyu WC, Lin SZ. Mesenchymal stem cells. Cell Transplant 2011; 20(1):5-14.22- Mıura M, Gronthos S, Zhao M, Lu B, Fısher Lw, Rober Pg,Shı S. (2003) Shed: stem cells from human exfoliated deciduous tetth.Proc Natl Acad Sci USA. 100:5807-12.23- Gronthos S, Mankanı M, Brahım J, Robey Pg, Shı S. (2000) Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo.Proc Natl Acad Sci USA. 97:13625-30.24- Shı S, Robery Pg, Gronthos S. (2001) Comparison of human dental pulp and bone marrow stromal stem cells by cDNA microarray analysis. Bone. 29:532-9.25- Morsczeck C, Götz W, Schıerholz J, Zeılhofer F, Kühn U,Moehl C, Sıppel C, Hoffmann Kh. (2005a) Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth. Matrix Biol. 24:155–65.26- Morsczeck C, Moehl C, Götz W, Heredıa A, Schaffer Te,Ecksteın N, Sıppel C, Hoffmann Kh. (2005b) Differentiation in vitro of human dental follicle cells with dexamethasone and insulin. Cell Biol Int. 29:567–75.27- Seo Bm, Mıura M, Gronthos S, Bartold Pm, Batoulı S,Brahım J. (2004) Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet. 364:149-55.28- Nagatomo K, Komakı M, Sekıya I, Sakaguchı Y, Noguchı K,Oda S, Muneta T, Ishıkawa I. (2006) Stem cell properties of human periodontal ligament cells. J Periodont Res. 41:303–10.29- Izumı K, Tobıta T, Feınberg Se. (2007) Isolation of human oral keratinocyte Progenitor/Stem Cells. J Dent Res. 86:341-6.30- Matsubara T,Suardıta K, Ishıı M, Sugıyama M, Igarashı A,Oda R, Nıshımura M, Saıto M, Nakagawa K,Yamanaka K,Mıyazakı K,Shımızu M, Bhawal Uk, Tsujı K, Nakamura K,Kato Y.(2005) Alveolar bone marrow as a cell source for regenerative medicine: differences between alveolar and iliac bone marrow stromal cells. J Bone Miner Res. 20:399-409.31- Cıcconettı A, Sacchettı B, Bartolı A, Mıchıenzı S, Corsı A, Funarı A, Robey Pg, Bıanco P, Rımınuccı M. (2007) Human maxillary tuberosity and jaw periosteum as sources of osteoprogenitor cells for tissue engineering. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 104:618.e1-12.32- Handa K, Saıto M, Yamauchı M, Kıyono T, Sato S, Teranaka T, Sampath Narayanan A. (2002a) Cementum matrix formation invivo by cultured dental follicle cells. Bone. 31: 606-11.33- Handa K, Saıto M, Tsunoda A, Yamauchı M, Hattorı S, Satos, Toyoda M, Teranaka T, Narayanan As. (2002) Progenitor cells from dental follicle are able to form cementum matrix in vivo. Connect Tissue Res. 43:406-8.34- Laurell L, Gottlow J, Zybutz M, Persson R. Treatment of intrabony defects by different surgical procedures. A literature review. J Periodontol. 1998;69(3):303–313.35- Garcia-Godoy F, Murray PE. Status and potential commercial impact of stem cell-based treatments on dental and craniofacial regeneration. Stem Cells Dev. 2006;15(6):881-887)36- Kuznetsov SA, Krebsbach PH, Satomura K,et al. Single-colony derived strains of human marrow stromal fibroblasts form bone after transplantation in vivo. J Bone Miner Res 1997;12:1335-47.37- Kim SH , Kim KH, Seo BM , Koo KT, Kim T, Seol YJ, Young K, Rhyu C,Chung CP, Lee YM. Alveolar bone regeneration by transplantation of periodontal ligament stem cells and bone marrow stem cells in canine peri-implant defects model: A pilot study. J Periodontol 2009; posted online on july22.38- Kawaguchi H, Hayashi H, Mizuno N, Fujita T,Hasegawa N, Shiba H,Nakamura S, Hino T,Yoshino H, Kurihara H, Tanaka H, Kimura A,Tsuji K, Kato Y. Cell transplantation for periodontal diseases. A novel periodontal tissue regenerative therapy using bone marrow mesenchymal stem cells.Clin Calcium.2005;15(7):99-104.39- Yamada Y, Ueda M, Hideharu H, Baba S. Novel approach to periodontal tissue regeneration with mesenchymal stem cells and platelet-rich plasma using tissue engineering technology: A clinical case report. Int. J. Periodont. Rest. Dent. 2006;26(4): 363-369.40- Taguchi K, Ogawa R, Migita M, Hanawa H, Ito H, Orimo H:The role of bone marrow-derived cells in bone fracture repair in a green fluorescent protein chimeric Mouse model.Biochem Biophys Res Commun 2005 ;27; 331(1):31-36.41- Shirley D, Marsh D, Jordan G, McQuaid S, Li G. Systemic recruitment of osteoblastic cells in fracture healing.J Orthop Res 2005;23(5):1013-1021.42- Ural AU, Demiralp B, Avcu F, Yurttaş Y,Canpolat E, Can B, et al. Allojenik mezenkimal kök hücrelerin tavşan tibial segmentel kemik defekti tamirinde kullanımı. Turkish Journal of Hematology. Supplament 2004; 21 (3):48.43- Hidaka C, Goshi K, Rawlins B, Boachie-Adjei O, Crystal RG: Enhancement of spine fusion using combined gene therapy and tissue engineering BMP-7-expressing bone marrow cells and allograft bone.Spine 2003;28(18):2049-2057.44- Pereira RF, O'Hara MD, Laptev AV, Halford KW, Pollard MD, Class R, et al. Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta. Proc Natl Acad Sci U S A 1998; 95(3):1142-1147.45- Horwitz EM, Prockop DJ, Gordon PL, Koo WW, Fitzpatrick LA, Neel MD, et al. Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta.Blood 2001; 97(5):1227-1231.46- Horwitz EM, Prockop DJ, Fitzpatrick LA, Koo WW, Gordon PL,Neel M,et al. Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med 1999; 5(3):309-313.47- Gimbel M, Ashley RK, Sisodia M, Gabbay JS, Wasson KL, Heller J, et al. Repair of alveolar cleft defects: reduced morbidity with bone marrow stem cells in a resorbable matrix. J Craniofac Surg 2007;18(4):895-901.48- Shayesteh YS, Khojasteh A, Soleimani M, Alikhasi M, Khoshzaban A, Ahmadbeigi N.Sinus augmentation using human mesenchymal stem cells loaded into a beta-tricalciumphosphate/hydroxyapatite scaffold. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;106:203-9.49- D’Aquino R, De RA, Lanza V, Tirino V, Laino L, Graziano A. Human mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexes. Eur Cell Mater 2009;18:75-83.
Year 2019, Volume: 2 Issue: 2, 86 - 94, 18.12.2019

Abstract

References

  • KAYNAKLAR:1- Cheung TH, Rando TA. Molecular regulation of stem cell quiescence. Nat Rev Mol Cell Biol 2013;14:329-40.2- Martin GR. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proceedings of the National Academy of Sciences of the United States of America 1981;78:7634-8.3- Korbling M, Estrov Z. Adult stem cells for tissue repair. a new therapeutic concept? The New England Journal of Medicine 2003;349:570-82.4- Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007;318:1917-20.5- Maria OM, Khosravi R, Mezey E,Tran SD. Cells from bone marrow that evolve into oral tissues and their clinical applications.Oral Dis 2007; 13: 11-16.6- Özel BH, Ozan E, Dabak DÖ. Embriyonik Kök Hücreler. Türkiye Klinikleri J Med Sci 2008; 28: 333-341.7- Nedel F, Almeida D, Oliveria I, Mabel M, Casagrande L, Fernando F. The rapeutic potential in dentistry. J Contemp Dent Pract 2009;10(4):90-96.8- Tekeli S, Arısu Naghavi E, Gökçe B, Sır G, Yiğittürk G, Çavuşoğlu T ve ark. Kök hücreler; mezenkimal kök hücreler ve güncel klinik uygulamaları. FNG & Bilim Tıp Transplantasyon Dergisi 2016;1:72-83.9- Trounson A, McDonald C. Stem Cell Therapies in Clinical Trials: Progress and Challenges. Cell Stem Cell 2015;17:11-22.10- Kılıç KD, Başaloğlu HK, Uyanikgil Y, Turgut M.Current Topics on Cancer Stem Cell Associated Melanoma Treatment Researches. J Brain Tumors Neurooncol 2017;2:1.11- George B (2011): Regulations and guidelines governing stem cell based products: Clinical considerations. Perspect Clin Res, 2:94-9612- Gronthos S, Chen S, Wang CY, Robey PG, Shi S. Telomerase accelerates osteogenesis of bone marrow stromal stem cells by upregulation of CBFA1, osterix, and osteocalcin. J Bone Miner Res 2003;18(4):716-22.13- Stewart R, Stojkovic M, Lako M. Mechanisms of self-renewal in human embryonic stem cells. Eur J Cancer 2006;42(9):1257-72.14- Wada N, Menicanin D, Shi S, Bartold PM, Gronthos S. Immunomodulatory properties of human periodontal ligament stem cells. J Cell Physiol 2009;219(3):667-7615- da Silva Meirelles L, Chagastelles PC, Nardi NB.Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci 2006;119:220416- Hasan A, Deeb G, Rahal R, Atwi K, Mondello S, Marei HE, et al. Mesenchymal Stem Cells in the Treatment of Traumatic Brain Injury. Front Neurol 2017;8:28.17- Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999, 284(5411):143-147.18- Csaki C, Matis U, Mobasheri A, Ye H (2007):Chondrogenesis, osteogenesis and adipogenesis of canine mesenchymal stem cell: a biochemical,morphological and ultrastructural study. Histochem Cell Biol,128: 507-20.19- Kim JW, Lee JH, Lyoo YS, Jung DI, Park HM (2013) The effects of topical mesenchymal stem cell transplantation in canine experimental cutaneous wounds.Vet Dermatol, 24: 242-253.20- Pasquinelli G, Tazzari P, Ricci F, Vaselli C, Buzzi M, Conte R (2007): Ultrastructural Characteristics of Human Mesenchymal Stromal (Stem) Cells Derived from Bone Marrow and Term Placenta. Ultrastructural Pathology, 31:23-31.21- Ding DC(1), Shyu WC, Lin SZ. Mesenchymal stem cells. Cell Transplant 2011; 20(1):5-14.22- Mıura M, Gronthos S, Zhao M, Lu B, Fısher Lw, Rober Pg,Shı S. (2003) Shed: stem cells from human exfoliated deciduous tetth.Proc Natl Acad Sci USA. 100:5807-12.23- Gronthos S, Mankanı M, Brahım J, Robey Pg, Shı S. (2000) Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo.Proc Natl Acad Sci USA. 97:13625-30.24- Shı S, Robery Pg, Gronthos S. (2001) Comparison of human dental pulp and bone marrow stromal stem cells by cDNA microarray analysis. Bone. 29:532-9.25- Morsczeck C, Götz W, Schıerholz J, Zeılhofer F, Kühn U,Moehl C, Sıppel C, Hoffmann Kh. (2005a) Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth. Matrix Biol. 24:155–65.26- Morsczeck C, Moehl C, Götz W, Heredıa A, Schaffer Te,Ecksteın N, Sıppel C, Hoffmann Kh. (2005b) Differentiation in vitro of human dental follicle cells with dexamethasone and insulin. Cell Biol Int. 29:567–75.27- Seo Bm, Mıura M, Gronthos S, Bartold Pm, Batoulı S,Brahım J. (2004) Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet. 364:149-55.28- Nagatomo K, Komakı M, Sekıya I, Sakaguchı Y, Noguchı K,Oda S, Muneta T, Ishıkawa I. (2006) Stem cell properties of human periodontal ligament cells. J Periodont Res. 41:303–10.29- Izumı K, Tobıta T, Feınberg Se. (2007) Isolation of human oral keratinocyte Progenitor/Stem Cells. J Dent Res. 86:341-6.30- Matsubara T,Suardıta K, Ishıı M, Sugıyama M, Igarashı A,Oda R, Nıshımura M, Saıto M, Nakagawa K,Yamanaka K,Mıyazakı K,Shımızu M, Bhawal Uk, Tsujı K, Nakamura K,Kato Y.(2005) Alveolar bone marrow as a cell source for regenerative medicine: differences between alveolar and iliac bone marrow stromal cells. J Bone Miner Res. 20:399-409.31- Cıcconettı A, Sacchettı B, Bartolı A, Mıchıenzı S, Corsı A, Funarı A, Robey Pg, Bıanco P, Rımınuccı M. (2007) Human maxillary tuberosity and jaw periosteum as sources of osteoprogenitor cells for tissue engineering. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 104:618.e1-12.32- Handa K, Saıto M, Yamauchı M, Kıyono T, Sato S, Teranaka T, Sampath Narayanan A. (2002a) Cementum matrix formation invivo by cultured dental follicle cells. Bone. 31: 606-11.33- Handa K, Saıto M, Tsunoda A, Yamauchı M, Hattorı S, Satos, Toyoda M, Teranaka T, Narayanan As. (2002) Progenitor cells from dental follicle are able to form cementum matrix in vivo. Connect Tissue Res. 43:406-8.34- Laurell L, Gottlow J, Zybutz M, Persson R. Treatment of intrabony defects by different surgical procedures. A literature review. J Periodontol. 1998;69(3):303–313.35- Garcia-Godoy F, Murray PE. Status and potential commercial impact of stem cell-based treatments on dental and craniofacial regeneration. Stem Cells Dev. 2006;15(6):881-887)36- Kuznetsov SA, Krebsbach PH, Satomura K,et al. Single-colony derived strains of human marrow stromal fibroblasts form bone after transplantation in vivo. J Bone Miner Res 1997;12:1335-47.37- Kim SH , Kim KH, Seo BM , Koo KT, Kim T, Seol YJ, Young K, Rhyu C,Chung CP, Lee YM. Alveolar bone regeneration by transplantation of periodontal ligament stem cells and bone marrow stem cells in canine peri-implant defects model: A pilot study. J Periodontol 2009; posted online on july22.38- Kawaguchi H, Hayashi H, Mizuno N, Fujita T,Hasegawa N, Shiba H,Nakamura S, Hino T,Yoshino H, Kurihara H, Tanaka H, Kimura A,Tsuji K, Kato Y. Cell transplantation for periodontal diseases. A novel periodontal tissue regenerative therapy using bone marrow mesenchymal stem cells.Clin Calcium.2005;15(7):99-104.39- Yamada Y, Ueda M, Hideharu H, Baba S. Novel approach to periodontal tissue regeneration with mesenchymal stem cells and platelet-rich plasma using tissue engineering technology: A clinical case report. Int. J. Periodont. Rest. Dent. 2006;26(4): 363-369.40- Taguchi K, Ogawa R, Migita M, Hanawa H, Ito H, Orimo H:The role of bone marrow-derived cells in bone fracture repair in a green fluorescent protein chimeric Mouse model.Biochem Biophys Res Commun 2005 ;27; 331(1):31-36.41- Shirley D, Marsh D, Jordan G, McQuaid S, Li G. Systemic recruitment of osteoblastic cells in fracture healing.J Orthop Res 2005;23(5):1013-1021.42- Ural AU, Demiralp B, Avcu F, Yurttaş Y,Canpolat E, Can B, et al. Allojenik mezenkimal kök hücrelerin tavşan tibial segmentel kemik defekti tamirinde kullanımı. Turkish Journal of Hematology. Supplament 2004; 21 (3):48.43- Hidaka C, Goshi K, Rawlins B, Boachie-Adjei O, Crystal RG: Enhancement of spine fusion using combined gene therapy and tissue engineering BMP-7-expressing bone marrow cells and allograft bone.Spine 2003;28(18):2049-2057.44- Pereira RF, O'Hara MD, Laptev AV, Halford KW, Pollard MD, Class R, et al. Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta. Proc Natl Acad Sci U S A 1998; 95(3):1142-1147.45- Horwitz EM, Prockop DJ, Gordon PL, Koo WW, Fitzpatrick LA, Neel MD, et al. Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta.Blood 2001; 97(5):1227-1231.46- Horwitz EM, Prockop DJ, Fitzpatrick LA, Koo WW, Gordon PL,Neel M,et al. Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med 1999; 5(3):309-313.47- Gimbel M, Ashley RK, Sisodia M, Gabbay JS, Wasson KL, Heller J, et al. Repair of alveolar cleft defects: reduced morbidity with bone marrow stem cells in a resorbable matrix. J Craniofac Surg 2007;18(4):895-901.48- Shayesteh YS, Khojasteh A, Soleimani M, Alikhasi M, Khoshzaban A, Ahmadbeigi N.Sinus augmentation using human mesenchymal stem cells loaded into a beta-tricalciumphosphate/hydroxyapatite scaffold. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;106:203-9.49- D’Aquino R, De RA, Lanza V, Tirino V, Laino L, Graziano A. Human mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexes. Eur Cell Mater 2009;18:75-83.
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Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Reviews
Authors

Zozan Erdoğmuş 0000-0002-9706-3862

Publication Date December 18, 2019
Submission Date October 24, 2019
Acceptance Date November 17, 2019
Published in Issue Year 2019 Volume: 2 Issue: 2

Cite

APA Erdoğmuş, Z. (2019). Mezenkimal Kök Hücre Ve Maksiilofasiyal Cerrahide Kullanımı. İzlek Akademik Dergi, 2(2), 86-94.


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