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Hemodialysis Associated Methemoglobinemia: A Case Report

Year 2024, Volume: 3 Issue: 4, 171 - 175, 20.12.2024
https://doi.org/10.57221/izmirtip.1423981

Abstract

Methemoglobin is a non-functional type of hemoglobin that forms as a result of the oxidation of iron from the ferrous form (+2) to the ferric form (+3). While normal individuals have methemoglobin levels between 1-2%, in patients with methemoglobinemia, tissue perfusion can be severely compromised, with levels of 70% or higher leading to fatal outcomes. In this case,we present the management of a patient refered from emergency department with cyanosis and diagnosed with methemoglobinemia.

References

  • 1. Prchal JT. Methemoglobinemia and other dyshemoglobinemias. Chap 51. In: Williams Hematology, 10th ed, Kaushansky K, Litchtman MA, Prchal JT, et al (Eds), McGraw Hill, New York 2021. p.859.
  • 2. Jaffe E, Hultquist D. Cytochrome b5 reductase deficiency and enzymopenic hereditary methemoglobinemia. In: The metabolic and molecular bases of inherited disease, 7th ed, Scriver C, Beaudet A, Sly W, Valle D (Eds), McGraw Hill, New York 1995. Vol 3, p.3399.
  • 3. Nakata M, Yokota N, Tabata K, Morikawa T, Shibata H, Kenzaka T. Hereditary congenital methemoglobinemia diagnosed at the age of 79 years: a case report. Medicina (Kaunas). 2023;59:615.
  • 4. Meslek hastalıkları ve işle ilgili hastalıklar tanı rehberi. Çalışma ve Sosyal Güvenlik Bakanlığı. https://www.csgb.gov.tr/medias/4597/rehber20.pdf
  • 5. Sahu KK, Lal A, Mishra A, George S. Food poisoning associated methemoglobinemia: time to wake up. World J Emerg Med. 2020;11:127-8.
  • 6. Greenberg KI, Choi MJ. Hemodialysis emergencies: core curriculum. Am J Kidney Dis. 2021;77:796-809. 7. Cefalu JN, Joshi TV, Spalitta MJ, Kadi CJ, Diaz JH, Eskander JP, et al. Methemoglobinemia in the operating room and ıntensive care unit: early recognition, pathophysiology, and management. Adv Ther. 2020;37:1714-23.
  • 8. De Torres JP, Strom JA, Jaber BL, Hendra KP. Hemodialysis-associated methemoglobinemia in acute renal failure. Am J Kidney Dis. 2002;39:1307-9.
  • 9. Skold A, Cosco DL, Klein R. Methemoglobinemia: pathogenesis, diagnosis, and management. South Med J. 2011;104:757-61.
  • 10. Elmas B, Koçer GB, Özdemir Ö. İntravenöz askorbik asid ile birlikte oral metilen mavisi kullanılan, prilokaine bağlı methemoglobinemi: vaka takdimi. Sakarya Tıp Dergisi. 2016;6:245-8.
  • 11. Chávez-Iñiguez JS, Medina-González R, Ron-Magaña A, Madero M, Ramírez-Ramírez AC, Rifkin BS, et al. Methemoglobinemia in hemodialysis patients due to acute chlorine ıntoxication: a case series calling attention on an old problem. Blood Purif. 2023;52:835-43.
  • 12. Medarov BI, Pahwa S, Reed S, Blinkhorn R, Rane N, Judson MA. Methemoglobinemia caused by portable dialysis in the critically ill. Crit Care Med. 2017;45:e232-5.
  • 13. Gok M, Aydemir YG. Methemoglobinemia in pregnancy with chronic kidney disease an uncommon case: a case report. J Pak Med Assoc. 2022;72:363-65.
  • 14. Torabi J, Campbell A, Nair G, Patel GL, Miura Y, Graham JA. Dapsone-induced methemoglobinemia in two renal transplant recipients. Prog Transplant. 2019;29:289-90.

Hemodiyalize Bağlı Methemoglobinemi: Olgu Sunumu

Year 2024, Volume: 3 Issue: 4, 171 - 175, 20.12.2024
https://doi.org/10.57221/izmirtip.1423981

Abstract

Methemoglobin fonksiyonel olmayan bir hemoglobin tipi olup demirin ferröz formundan (+2) ferrik forma (+3) oksidasyonu sonucu oluşur. Normal bireylerde methemoglobin düzeyi %1-2 arası iken methemoglobinemisi olan hastalarda %70 ve üzerinde doku perfüzyonunun bozulmasına bağlı ölümcül seyredebilir. Bu olgu sunumunda acil servise periferik ve santral siyanoz ile başvuran methemoglobinemi saptanan hastanın dahili açıdan yönetimi anlatılacaktır

References

  • 1. Prchal JT. Methemoglobinemia and other dyshemoglobinemias. Chap 51. In: Williams Hematology, 10th ed, Kaushansky K, Litchtman MA, Prchal JT, et al (Eds), McGraw Hill, New York 2021. p.859.
  • 2. Jaffe E, Hultquist D. Cytochrome b5 reductase deficiency and enzymopenic hereditary methemoglobinemia. In: The metabolic and molecular bases of inherited disease, 7th ed, Scriver C, Beaudet A, Sly W, Valle D (Eds), McGraw Hill, New York 1995. Vol 3, p.3399.
  • 3. Nakata M, Yokota N, Tabata K, Morikawa T, Shibata H, Kenzaka T. Hereditary congenital methemoglobinemia diagnosed at the age of 79 years: a case report. Medicina (Kaunas). 2023;59:615.
  • 4. Meslek hastalıkları ve işle ilgili hastalıklar tanı rehberi. Çalışma ve Sosyal Güvenlik Bakanlığı. https://www.csgb.gov.tr/medias/4597/rehber20.pdf
  • 5. Sahu KK, Lal A, Mishra A, George S. Food poisoning associated methemoglobinemia: time to wake up. World J Emerg Med. 2020;11:127-8.
  • 6. Greenberg KI, Choi MJ. Hemodialysis emergencies: core curriculum. Am J Kidney Dis. 2021;77:796-809. 7. Cefalu JN, Joshi TV, Spalitta MJ, Kadi CJ, Diaz JH, Eskander JP, et al. Methemoglobinemia in the operating room and ıntensive care unit: early recognition, pathophysiology, and management. Adv Ther. 2020;37:1714-23.
  • 8. De Torres JP, Strom JA, Jaber BL, Hendra KP. Hemodialysis-associated methemoglobinemia in acute renal failure. Am J Kidney Dis. 2002;39:1307-9.
  • 9. Skold A, Cosco DL, Klein R. Methemoglobinemia: pathogenesis, diagnosis, and management. South Med J. 2011;104:757-61.
  • 10. Elmas B, Koçer GB, Özdemir Ö. İntravenöz askorbik asid ile birlikte oral metilen mavisi kullanılan, prilokaine bağlı methemoglobinemi: vaka takdimi. Sakarya Tıp Dergisi. 2016;6:245-8.
  • 11. Chávez-Iñiguez JS, Medina-González R, Ron-Magaña A, Madero M, Ramírez-Ramírez AC, Rifkin BS, et al. Methemoglobinemia in hemodialysis patients due to acute chlorine ıntoxication: a case series calling attention on an old problem. Blood Purif. 2023;52:835-43.
  • 12. Medarov BI, Pahwa S, Reed S, Blinkhorn R, Rane N, Judson MA. Methemoglobinemia caused by portable dialysis in the critically ill. Crit Care Med. 2017;45:e232-5.
  • 13. Gok M, Aydemir YG. Methemoglobinemia in pregnancy with chronic kidney disease an uncommon case: a case report. J Pak Med Assoc. 2022;72:363-65.
  • 14. Torabi J, Campbell A, Nair G, Patel GL, Miura Y, Graham JA. Dapsone-induced methemoglobinemia in two renal transplant recipients. Prog Transplant. 2019;29:289-90.
There are 13 citations in total.

Details

Primary Language English
Subjects Nefroloji
Journal Section Case Reports
Authors

Harun Akar 0000-0002-0936-8691

Ayşe Nur Cengiz 0000-0002-8754-1293

Publication Date December 20, 2024
Submission Date January 22, 2024
Acceptance Date September 27, 2024
Published in Issue Year 2024 Volume: 3 Issue: 4

Cite

APA Akar, H., & Cengiz, A. N. (2024). Hemodialysis Associated Methemoglobinemia: A Case Report. İzmir Tıp Fakültesi Dergisi, 3(4), 171-175. https://doi.org/10.57221/izmirtip.1423981
AMA Akar H, Cengiz AN. Hemodialysis Associated Methemoglobinemia: A Case Report. Journal of Izmir Med. Faculty. December 2024;3(4):171-175. doi:10.57221/izmirtip.1423981
Chicago Akar, Harun, and Ayşe Nur Cengiz. “Hemodialysis Associated Methemoglobinemia: A Case Report”. İzmir Tıp Fakültesi Dergisi 3, no. 4 (December 2024): 171-75. https://doi.org/10.57221/izmirtip.1423981.
EndNote Akar H, Cengiz AN (December 1, 2024) Hemodialysis Associated Methemoglobinemia: A Case Report. İzmir Tıp Fakültesi Dergisi 3 4 171–175.
IEEE H. Akar and A. N. Cengiz, “Hemodialysis Associated Methemoglobinemia: A Case Report”, Journal of Izmir Med. Faculty, vol. 3, no. 4, pp. 171–175, 2024, doi: 10.57221/izmirtip.1423981.
ISNAD Akar, Harun - Cengiz, Ayşe Nur. “Hemodialysis Associated Methemoglobinemia: A Case Report”. İzmir Tıp Fakültesi Dergisi 3/4 (December 2024), 171-175. https://doi.org/10.57221/izmirtip.1423981.
JAMA Akar H, Cengiz AN. Hemodialysis Associated Methemoglobinemia: A Case Report. Journal of Izmir Med. Faculty. 2024;3:171–175.
MLA Akar, Harun and Ayşe Nur Cengiz. “Hemodialysis Associated Methemoglobinemia: A Case Report”. İzmir Tıp Fakültesi Dergisi, vol. 3, no. 4, 2024, pp. 171-5, doi:10.57221/izmirtip.1423981.
Vancouver Akar H, Cengiz AN. Hemodialysis Associated Methemoglobinemia: A Case Report. Journal of Izmir Med. Faculty. 2024;3(4):171-5.