In vitro antioxidant activity and carbonic anhydrase inhibitory features of Ferula communis extracts

Fatma Aydın; Zeynep Aleyna Kahraman; Emir Alper Türkoğlu; Müslüm Kuzu; Zeki Severoğlu

doi:10.31015/jaefs.2021.4.19

EN

In vitro antioxidant activity and carbonic anhydrase inhibitory features of Ferula communis extracts

Abstract

Carbonic anhydrases (CAs; EC 4.2.1.1) are essential family of metalloenzymes which catalyze the interconversion between carbon dioxide (CO2) and bicarbonate (HCO3-) in all organisms of three-domains of life. Huge amounts of attempts related to catalytic activity of CAs have been widely expanded to treat many clinical diseases. This study aimed to determine in-vitro antioxidant activities and human CA I (hCA I) and II (hCA II) inhibitory properties of Ferula communis extracts. Among all extracts of F. communis, the hexane extract has showed the best inhibitory profile on hCA I and II with IC50 values 8.68 µg/mL and 28 µg/mL and Ki values 2.026 µg/mL and 11.6 µg/mL, respectively. All extracts showed mild to moderate antioxidant activity. According to the results of DPPH assay, ethanol-water extract showed the highest activity with IC50: 0.1128±0.0066 value. Chloroform extract showed the highest activity on CUPRAC assay with the value of 1.305±0.037 mM Trolox equivalent/mg extract. However, further analytical, in-vivo and clinical studies are needed to confirm the activities of F. communis.

Keywords

Antioxidant activity, Carbonic anhydrase, Ferula communis, Inhibition

Supporting Institution

TÜBİTAK and Scientific Research Project Fund of the University of Health Sciences Turkey

Project Number

TUBITAK 2209-A University Students Research Projects Support Program for Zeynep Aleyna KAHRAMAN and Scientific Research Project Fund of the University of Health Sciences Turkey under project number 2018/011.

Thanks

We also would like to thank our collaborator, Assoc. Prof. Dr. Turgut TAŞKIN, for his excellent recommendations.

References

Abdel-Aziz, A. A.-M., El-Azab, A. S., Ceruso, M., Supuran, C. T. (2014). Carbonic anhydrase inhibitory activity of sulfonamides and carboxylic acids incorporating cyclic imide scaffolds. Bioorganic & Medicinal Chemistry Letters, 24(22), 5185-5189. Doi: https://doi.org/10.1016/j.bmcl.2014.09.076
Aggarwal, M., Boone, C. D., Kondeti, B., McKenna, R. (2013). Structural annotation of human carbonic anhydrases. Journal of Enzyme Inhibition and Medicinal Chemistry, 28(2), 267-277. Doi: https://doi.org/10.3109/14756366.2012.737323
Ağgül, A., Kuzu, M., Kandemir, F., Küçükler, S., Çağlayan, C. (2020). Alterations in enzyme activity of carbonic anhydrase, 6-phosphogluconate dehydrogenase and thioredoxin reductase in rats exposed to doxorubicin and morin. Clinical and Experimental Health Sciences, 10(3), 228-234. Retrieved from https://dergipark.org.tr/en/pub/clinexphealthsci/issue/56955/632320
Ahmad, S., Hassan, A., Rehman, T., Basit, A., Tahir, A., Adeel Arshad, M. (2019). In vitro bioactivity of extracts from seeds of Cassia absus l. growing in Pakistan. Journal of Herbal Medicine, 100258. Doi: https://doi.org/10.1016/j.hermed.2019.100258
Akaberi, M., Iranshahy, M., Iranshahi, M. (2015). Review of the traditional uses, phytochemistry, pharmacology and toxicology of giant fennel (Ferula communis L. subsp. communis). Iranian Journal of Basic Medical Sciences, 18(11), 1050-1062. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764105/
Akbaba, Y., Balaydın, H. T., Menzek, A., Göksu, S., Şahin, E., Ekinci, D. (2013). Synthesis and Biological Evaluation of Novel Bromophenol Derivatives as Carbonic Anhydrase Inhibitors. Archiv Der Pharmazie, 346(6), 447-454. Doi: https://doi.org/10.1002/ardp.201300054
Akkemik, E., Aybek, A., Felek, I. (2019). Effects of cefan melon (Cucumıs melo l.) seed extracts on human erythrocyte carbonic anhydrase I-II enzymes, Applied Ecology and Environmental Research, 17(6), 14699-14713. Doi: https://doi.org/10.15666/aeer/1706_1469914713
Almajan, G. L., Barbuceanu, S.-F., innocenti, A., Scozzafava, A., Supuran, C. T. (2008). Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II and IX with some 1,3,4-oxadiazole- and 1,2,4-triazole-thiols. Journal of Enzyme Inhibition and Medicinal Chemistry, 23(1), 101-07. Doi: https://doi.org/10.1080/14756360701342417
Amir Aslani, B., Ghobadi, S. (2016). Studies on oxidants and antioxidants with a brief glance at their relevance to the immune system. Life Sciences, 146, 163-173. Doi: https://doi.org/10.1016/j.lfs.2016.01.014
Arnoldi, L., Ballero, M., Fuzzati, N., Maxia, A., Mercalli, E., Pagni, L. (2004). HPLC-DAD-MS identification of bioactive secondary metabolites from Ferula communis roots. Fitoterapia, 75(3-4), 342-354. Doi: https://doi.org/10.1016/j.fitote.2004.03.001

Arslan, T., Türkoğlu, E. A., Şentürk, M., Supuran, C. T. (2016). Synthesis and carbonic anhydrase inhibitory properties of novel chalcone substituted benzenesulfonamides. Bioorganic & Medicinal Chemistry Letters, 26(24), 5867-5870. Doi: https://doi.org/10.1016/j.bmcl.2016.11.017
Balaydın, H. T., Şentürk, M., Göksu, S., Menzek, A. (2012). Synthesis and carbonic anhydrase inhibitory properties of novel bromophenols and their derivatives including natural products: Vidalol B. European Journal of Medicinal Chemistry, 54, 423-428. Doi: https://doi.org/10.1016/j.ejmech.2012.05.025
Balaydin, H. T., Durdaği, S., Ekinci, D., Şentürk, M., Göksu, S., Menzek, A. (2012). Inhibition of human carbonic anhydrase isozymes I, II and VI with a series of bisphenol, methoxy and bromophenol compounds. Journal of Enzyme Inhibition and Medicinal Chemistry, 27(4), 467-475. Doi: https://doi.org/10.3109/14756366.2011.596836
Carta, F., Ferraroni, M., Scozzafava, A., Supuran, C. T. (2016). Fluorescent sulfonamide carbonic anhydrase inhibitors incorporating 1,2,3-triazole moieties: Kinetic and X-ray crystallographic studies. Bioorganic & Medicinal Chemistry, 24(2), 104-112. Doi: https://doi.org/10.1016/j.bmc.2015.11.031
Ceruso, M., Antel, S., Vullo, D., Scozzafava, A., Supuran, C. T. (2014). Inhibition studies of new ureido-substituted sulfonamides incorporating a GABA moiety against human carbonic anhydrase isoforms I-XIV. Bioorganic & Medicinal Chemistry, 22(24), 6768-6775. Doi: https://doi.org/10.1016/j.bmc.2014.10.041
Ceylan, S., Cetin, S., Camadan, Y., Saral, O., Ozsen, O., Tutus, A. (2019). Antibacterial and antioxidant activities of traditional medicinal plants from the Erzurum region of Turkey. Irish Journal of Medical Science, 188(4), 1303-1309. Doi: https://doi.org/10.1007/s11845-019-01993-x
Çetinkaya, Y., Göçer, H., Gülçin, İ., Menzek, A. (2014). Synthesis and carbonic anhydrase isoenzymes ınhibitory effects of brominated diphenylmethanone and ıts derivatives. Archiv Der Pharmazie, 347(5), 354-359. Doi: https://doi.org/10.1002/ardp.201300349
De Simone, G., Supuran, C. T. (2012). (In)organic anions as carbonic anhydrase inhibitors. Journal of Inorganic Biochemistry, 111, 117-129. Doi: https://doi.org/10.1016/j.jinorgbio.2011.11.017
Ekinci, D., Çavdar, H., Talaz, O., Şentürk, M., Supuran, C. T. (2010). NO-releasing esters show carbonic anhydrase inhibitory action against human isoforms I and II. Bioorganic & Medicinal Chemistry, 18(10), 3559-3563. Doi: https://doi.org/10.1016/j.bmc.2010.03.082
Fu, W., Chen, J., Cai, Y., Lei, Y., Chen, L., Pei, L., Zhou, D., Liang, X., Ruan, J. (2010). Antioxidant, free radical scavenging, anti-inflammatory and hepatoprotective potential of the extract from Parathelypteris nipponica (Franch. et Sav.) Ching. Journal of Ethnopharmacology, 130(3), 521–528. Doi: https://doi.org/10.1016/j.jep.2010.05.039
Gençer, N., Bilen, Ç., Demir, D., Atahan, A., Ceylan, M., Küçükislamoğlu, M. (2013). In vitro inhibition effect of some chalcones on erythrocyte carbonic anhydrase I and II. Artificial Cells, Nanomedicine, and Biotechnology, 41(6), 384-388. Doi: https://doi.org/10.3109/21691401.2012.761226 Güney, M., Çavdar, H., Şentürk, M., Ekinci, D. (2015). Synthesis and carbonic anhydrase inhibitory properties of novel uracil derivatives. Bioorganic & Medicinal Chemistry Letters, 25(16), 3261-3263. Doi: https://doi.org/10.1016/j.bmcl.2015.05.073
Iranshahi, M., Rezaee, R., Najaf Najafi, M., Haghbin, A., Kasaian, J. (2018). Cytotoxic activity of the genus Ferula (Apiaceae) and its bioactive constituents. Avicenna Journal of Phytomedicine, 8(4), 296-312. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204145/
Kähkönen, M. P., Hopia, A. I., Vuorela, H. J., Rauha, J.-P., Pihlaja, K., Kujala, T. S., Heinonen, M. (1999). Antioxidant Activity of Plant Extracts Containing Phenolic Compounds. Journal of Agricultural and Food Chemistry, 47(10), 3954-3962. Doi: https://doi.org/10.1021/jf990146l
Karataş, M. O., Alici, B., Çakir, Ü., Çetinkaya, E., Demir, D., Ergün, A., Gençer, N., Arslan, O. (2014). New coumarin derivatives as carbonic anhydrase inhibitors. Artificial Cells, Nanomedicine, and Biotechnology, 42(3), 192-198. Doi: https://doi.org/10.3109/21691401.2013.794352
Kaya, E., Erğun, B., Demir, Y., Alım, Z., Beydemir, Ş. (2019). The in vitro impacts of some plant extracts on carbonic anhydrase I, II and paraoxonase-1. Hacettepe Journal of Biology and Chemistry, 47(1), 51-59. Retrieved from https://dergipark.org.tr/en/pub/hjbc/issue/43015/553934
Korkmaz, N., Obaidi, O. A., Senturk, M., Astley, D., Ekinci, D., Supuran, C. T. (2015). Synthesis and biological activity of novel thiourea derivatives as carbonic anhydrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 30(1), 75-80. Doi: https://doi.org/10.3109/14756366.2013.879656
Kuzu, M., Aslan, A., Ahmed, I., Comakli, V., Demirdag, R., Uzun, N. (2016). Purification of glucose-6-phosphate dehydrogenase and glutathione reductase enzymes from the gill tissue of Lake Van fish and analyzing the effects of some chalcone derivatives on enzyme activities. Fish Physiology and Biochemistry, 42(2), 483-491. Doi: https://doi.org/10.1007/s10695-015-0153-7
Kuzu, M., Çomaklı, V., Akkemik, E., Çiftci, M., Küfrevioğlu, Ö. İ. (2018). Inhibitory properties of some heavy metals on carbonic anhydrase I and II isozymes activities purified from Van Lake fish (Chalcalburnus tarichi) gill. Fish Physiology and Biochemistry, 44(4), 1119-1125. Doi: https://doi.org/10.1007/s10695-018-0499-8
Le Darz, A., Mingot, A., Bouazza, F., Castelli, U., Karam, O., Tanc, M., Supuran, C. T., Thibaudeau, S. (2015). Fluorinated pyrrolidines and piperidines incorporating tertiary benzenesulfonamide moieties are selective carbonic anhydrase II inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 30(5), 737-745. Doi: https://doi.org/10.3109/14756366.2014.963072
Maślanka, T. (2015). A review of the pharmacology of carbonic anhydrase inhibitors for the treatment of glaucoma in dogs and cats. The Veterinary Journal, 203(3), 278-284. Doi: https://doi.org/10.1016/j.tvjl.2014.12.017
Mert, S., Alım, Z., İşgör, M. M., Beydemir, Ş., Kasımoğulları, R. (2016). The synthesis of novel pyrazole-3,4-dicarboxamides bearing 5-amino-1,3,4-thiadiazole-2-sulfonamide moiety with effective inhibitory activity against the isoforms of human cytosolic carbonic anhydrase I and II. Bioorganic Chemistry, 68, 64-71. Doi: https://doi.org/10.1016/j.bioorg.2016.07.006
Mete, E., Comez, B., Inci Gul, H., Gulcin, I., Supuran, C. T. (2016). Synthesis and carbonic anhydrase inhibitory activities of new thienyl-substituted pyrazoline benzenesulfonamides. Journal of Enzyme Inhibition and Medicinal Chemistry, 31, 1-5. Doi: https://doi.org/10.1080/14756366.2016.1181627
Nagao, C., Nagano, N., Mizuguchi, K. (2014). Prediction of detailed enzyme functions and identification of specificity determining residues by random forests. PLoS ONE, 9(1), e84623. Doi: https://doi.org/10.1371/journal.pone.0084623
Nar, M., Çetinkaya, Y., Gülçin, İ., Menzek, A. (2013). (3,4-Dihydroxyphenyl)(2,3,4-trihydroxyphenyl)methanone and its derivatives as carbonic anhydrase isoenzymes inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, 28(2), 402-406. Doi: https://doi.org/10.3109/14756366.2012.670807
Nguir, A., Mabrouk, H., Douki, W., Ben Ismail, M., Ben Jannet, H., Flamini, G., Hamza, M. A. (2016). Chemical composition and bioactivities of the essential oil from different organs of Ferula communis L. growing in Tunisia. Medicinal Chemistry Research, 25(3), 515-525. Doi: https://doi.org/10.1007/s00044-016-1506-1
Nocentini, A., Vullo, D., Bartolucci, G., Supuran, C. T. (2016). N-Nitrosulfonamides: A new chemotype for carbonic anhydrase inhibition. Bioorganic & Medicinal Chemistry, 24(16), 3612-3617. Doi: https://doi.org/10.1016/j.bmc.2016.05.072
Orhan, F., Şentürk, M., Supuran, C. T. (2016). Interaction of anions with a newly characterized alpha carbonic anhydrase from Halomonas sp. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(6), 1119-1123. Doi: https://doi.org/10.3109/14756366.2015.1100177
Ozensoy Guler, O., Capasso, C., Supuran, C. T. (2016). A magnificent enzyme superfamily: carbonic anhydrases, their purification and characterization. Journal of Enzyme Inhibition and Medicinal Chemistry, 1-6. Doi: https://doi.org/10.3109/14756366.2015.1059333
Ozensoy Guler, O., Supuran, C. T., Capasso, C. (2020). Carbonic anhydrase IX as a novel candidate in liquid biopsy. Journal of Enzyme Inhibition and Medicinal Chemistry, 35(1), 255-260. Doi: https://doi.org/10.1080/14756366.2019.1697251
Pernin, A., Dubois-Brissonnet, F., Roux, S., Masson, M., Bosc, V., Maillard, M. N. (2018). Phenolic compounds can delay the oxidation of polyunsaturated fatty acids and the growth of Listeria monocytogenes: structure-activity relationships. Journal of the Science of Food and Agriculture,98(14), 5401-5408. Doi: https://doi.org/10.1002/jsfa.9082
Rahali, F. Z., Kefi, S., Bettaieb Rebey, I., Hamdaoui, G., Tabart, J., Kevers, C., Franck, T., Mouithys-Mickalad, A., Hamrouni Sellami, I. (2018). Phytochemical composition and antioxidant activities of different aerial parts extracts of Ferula communis L. Plant Biosystems-An International Journal Dealing with All Aspects of Plant Biology, 1–9. Doi: https://doi.org/10.1080/11263504.2018.1461696
Salehi, M., Naghavi, M. R., Bahmankar, M. (2019). A review of Ferula species: Biochemical characteristics, pharmaceutical and industrial applications, and suggestions for biotechnologists. Industrial Crops and Products, 139, 111511. Doi: https://doi.org/10.1016/j.indcrop.2019.111511
Scozzafava, A., Mastrolorenzo, A., Supuran, C. T. (2004). Modulation of carbonic anhydrase activity and its applications in therapy. Expert Opinion on Therapeutic Patents, 14(5), 667-702. Doi: https://doi.org/10.1517/13543776.14.5.667
Supuran, C. T. (2008). Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nature Reviews Drug Discovery, 7(2), 168-181. Doi: https://doi.org/10.1038/nrd2467
Taski̇n, T., Levent, M., Sahi̇n, T. (2019). Investigation of the effects of biological activity and steeping time of four different black teas commercially valuable in Turkey. Clinical and Experimental Health Sciences, 9 (4), 283-287. Doi: https://doi.org/10.33808/clinexphealthsci.516099
Taslimi, P., Gülçin, İ., Öztaşkın, N., Çetinkaya, Y., Göksu, S., Alwasel, S. H., Supuran, C. T. (2016). The effects of some bromophenols on human carbonic anhydrase isoenzymes. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(4), 603-607. Doi: https://doi.org/10.3109/14756366.2015.1054820
Taşkın, D., Taşkın, T., Rayaman, E. (2018). Phenolic composition and biological properties of Achillea nobilis L. subsp. neilreichii (Kerner) Formanek. Industrial Crops and Products, 111, 555-562. Doi: https://doi.org/10.1016/j.indcrop.2017.11.022
Türkoğlu, E. A., Şentürk, M., Supuran, C. T., Ekinci, D. (2017). Carbonic anhydrase inhibitory properties of some uracil derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry, 32(1), 74-77. Doi: https://doi.org/10.1080/14756366.2016.1235043
Ucar, A., Findik, M., Kuzu, M., Pehlivanoglu, S., Sayin, U., Sayin, Z., Akgemci, E. G. (2020). Cytotoxic effects, microbiological analysis and inhibitory properties on carbonic anhydrase isozyme activities of 2-hydroxy-5-methoxyacetophenone thiosemicarbazone and its Cu(II), Co(II), Zn(II) and Mn(II) complexes. Research on Chemical Intermediates, 47, 533-550. Doi: https://doi.org/10.1007/s11164-020-04284-8
Uygun, M., Karagözler, A. A., Denizli, A. (2014). Molecularly imprinted cryogels for carbonic anhydrase purification from bovine erythrocyte. Artificial Cells, Nanomedicine, and Biotechnology, 42(2), 128-137. Doi: https://doi.org/10.3109/21691401.2013.864663
Verpoorte, J.A., Mehta, S., Edsall, J.T., (1967). Esterase activities of human carbonic anhydrases B and C. Journal of Biological Chemistry, 242; 4221-4229. Doi: https://doi.org/10.1016/S0021-9258(18)95800-X

Details

Primary Language

English

Subjects

Food Engineering

Journal Section

Research Article

Authors

Fatma Aydın
0000-0003-3320-8492
Türkiye

Zeynep Aleyna Kahraman
0000-0002-1038-017X
Türkiye

Emir Alper Türkoğlu ^*
0000-0001-7850-6456
Türkiye

Müslüm Kuzu
0000-0002-1375-7673
Türkiye

Zeki Severoğlu
0000-0002-3420-3557
Türkiye

Publication Date

December 15, 2021

Submission Date

March 14, 2021

Acceptance Date

August 31, 2021

Published in Issue

Year 2021 Volume: 5 Number: 4

DOI

https://doi.org/10.31015/jaefs.2021.4.19

IZ

https://izlik.org/JA58RC96HX

APA

Aydın, F., Kahraman, Z. A., Türkoğlu, E. A., Kuzu, M., & Severoğlu, Z. (2021). In vitro antioxidant activity and carbonic anhydrase inhibitory features of Ferula communis extracts. International Journal of Agriculture Environment and Food Sciences, 5(4), 592-598. https://doi.org/10.31015/jaefs.2021.4.19

AMA

1.Aydın F, Kahraman ZA, Türkoğlu EA, Kuzu M, Severoğlu Z. In vitro antioxidant activity and carbonic anhydrase inhibitory features of Ferula communis extracts. int. j. agric. environ. food sci. 2021;5(4):592-598. doi:10.31015/jaefs.2021.4.19

Chicago

Aydın, Fatma, Zeynep Aleyna Kahraman, Emir Alper Türkoğlu, Müslüm Kuzu, and Zeki Severoğlu. 2021. “In Vitro Antioxidant Activity and Carbonic Anhydrase Inhibitory Features of Ferula Communis Extracts”. International Journal of Agriculture Environment and Food Sciences 5 (4): 592-98. https://doi.org/10.31015/jaefs.2021.4.19.

EndNote

Aydın F, Kahraman ZA, Türkoğlu EA, Kuzu M, Severoğlu Z (December 1, 2021) In vitro antioxidant activity and carbonic anhydrase inhibitory features of Ferula communis extracts. International Journal of Agriculture Environment and Food Sciences 5 4 592–598.

IEEE

[1]F. Aydın, Z. A. Kahraman, E. A. Türkoğlu, M. Kuzu, and Z. Severoğlu, “In vitro antioxidant activity and carbonic anhydrase inhibitory features of Ferula communis extracts”, int. j. agric. environ. food sci., vol. 5, no. 4, pp. 592–598, Dec. 2021, doi: 10.31015/jaefs.2021.4.19.

ISNAD

Aydın, Fatma - Kahraman, Zeynep Aleyna - Türkoğlu, Emir Alper - Kuzu, Müslüm - Severoğlu, Zeki. “In Vitro Antioxidant Activity and Carbonic Anhydrase Inhibitory Features of Ferula Communis Extracts”. International Journal of Agriculture Environment and Food Sciences 5/4 (December 1, 2021): 592-598. https://doi.org/10.31015/jaefs.2021.4.19.

JAMA

1.Aydın F, Kahraman ZA, Türkoğlu EA, Kuzu M, Severoğlu Z. In vitro antioxidant activity and carbonic anhydrase inhibitory features of Ferula communis extracts. int. j. agric. environ. food sci. 2021;5:592–598.

MLA

Aydın, Fatma, et al. “In Vitro Antioxidant Activity and Carbonic Anhydrase Inhibitory Features of Ferula Communis Extracts”. International Journal of Agriculture Environment and Food Sciences, vol. 5, no. 4, Dec. 2021, pp. 592-8, doi:10.31015/jaefs.2021.4.19.

Vancouver

1.Fatma Aydın, Zeynep Aleyna Kahraman, Emir Alper Türkoğlu, Müslüm Kuzu, Zeki Severoğlu. In vitro antioxidant activity and carbonic anhydrase inhibitory features of Ferula communis extracts. int. j. agric. environ. food sci. 2021 Dec. 1;5(4):592-8. doi:10.31015/jaefs.2021.4.19

Cited By

Enzyme Inhibition and Antioxidant Activities of Asparagus officinalis L. and Analysis of Its Phytochemical Content by LC/MS/MS

Chemistry & Biodiversity

https://doi.org/10.1002/cbdv.202201231

IN VITRO EVALUATION OF ANTIOXIDANT AND CYTOTOXIC ACTIVITIES ON HUMAN CERVICAL CANCER CELLS IN THREE DIFFERENT PLANT EXTRACTS FROM TURKEY

Journal of Scientific Reports-A

https://doi.org/10.59313/jsr-a.1262754

Design, synthesis, and biological activity studies of carbonic anhydrase inhibitors

Zeitschrift für Naturforschung C

https://doi.org/10.1515/znc-2023-0102

Chemical Composition, Antioxidant Properties, Acute Toxicity, and Pharmacokinetic Evaluation of Aqueous Extract of Roots of Ferula communis L.

ChemistrySelect

https://doi.org/10.1002/slct.202403973

Ferula communis leaf extract: antioxidant capacity, UHPLC–MS/MS analysis, and in vivo and in silico toxicity investigations

Frontiers in Chemistry

https://doi.org/10.3389/fchem.2024.1485463

Abstracting & Indexing Services

Google Scholar | Crossref DOI Registry

All content published in this journal is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
Authors retain copyright of their work and grant the journal a non-exclusive right to publish, reproduce, and distribute the articles within an open-access framework.

Web: dergipark.org.tr/jaefs E-mail: editorialoffice@jaefs.com Phone / WhatsApp: +90 850 309 59 27

Abstract

In vitro antioxidant activity and carbonic anhydrase inhibitory features of Ferula communis extracts

Abstract

Keywords

Supporting Institution

Project Number

Thanks

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

Enzyme Inhibition and Antioxidant Activities of Asparagus officinalis L. and Analysis of Its Phytochemical Content by LC/MS/MS

IN VITRO EVALUATION OF ANTIOXIDANT AND CYTOTOXIC ACTIVITIES ON HUMAN CERVICAL CANCER CELLS IN THREE DIFFERENT PLANT EXTRACTS FROM TURKEY

Design, synthesis, and biological activity studies of carbonic anhydrase inhibitors

Chemical Composition, Antioxidant Properties, Acute Toxicity, and Pharmacokinetic Evaluation of Aqueous Extract of Roots of Ferula communis L.

Ferula communis leaf extract: antioxidant capacity, UHPLC–MS/MS analysis, and in vivo and in silico toxicity investigations

Abstracting & Indexing Services

© International Journal of Agriculture, Environment and Food Sciences