Year 2020, Volume 4 , Issue 2, Pages 230 - 235 2020-06-15

Homocysteine metabolism in rats with metabolic syndrome and the impacts of nigella sativa oil on some biochemical parameters

Naci ALAYUNT [1] , Bilal USTUNDAG [2]


The high level of fructose taken in the diet is one of the reasons for the increased prevalence of metabolic syndrome, which is increasing day by day globally in association with the effects of genetic and environmental factors. In the study, 21 male Sprague-Dawley rats of 220±20 gr body weight were used. The rats were assigned to 3 groups as the control group, metabolic syndrome group, and the group where Nigella sativa oil was administered. The serum homocysteine levels were increased in the metabolic syndrome group compared to the control group but without statistical significance (p>0.05). Homocysteine levels decreased significantly after Nigella sativa oil compared to metabolic syndrome group. LDH (p <0.001) and uric acid (p <0.05) levels which were higher in metabolic syndrome group were decreased in Nigella sativa oil group. Hyperhomocysteinemia is a risk factor for endothelial dysfunction. In our study, the treatment of the metabolic syndrome and regulation of the increased levels of homocysteine with Nigella sativa oil in metabolic syndrome were discussed. Some biochemical parameters and improvements in homocysteine levels with Nigella sativa oil has been identified. In this study, we have concluded that the occurrence of elevated levels of plasma homocysteine are closely associated with the development of inflammation, cellular adhesion, hepatic dysfunction, and cell proliferation and that the reduction in the serum levels of homocysteine by the administration of Nigella sativa oil will lead to favorable out comes.
Homocysteine, Metabolic syndrome, Nigella sativa oil, Vanillylmandelic acid
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Primary Language en
Subjects Food Science and Technology
Published Date June 2020
Journal Section Research Articles
Authors

Orcid: 0000-0003-2215-0934
Author: Naci ALAYUNT (Primary Author)
Institution: Siirt University, Faculty of Medicine, Department of Medical Biochemistry, Siirt, Turkey
Country: Turkey


Orcid: 0000-0001-6621-2450
Author: Bilal USTUNDAG
Institution: Firat University, Faculty of Medicine, Department of Medical Biochemistry, Elazig, Turkey
Country: Turkey


Supporting Institution Fırat University Scientific Research Projects
Project Number TF.14.41
Thanks Thank you to Fırat University Scientific Research Projects
Dates

Application Date : April 6, 2020
Acceptance Date : June 6, 2020
Publication Date : June 15, 2020

Bibtex @research article { jaefs715446, journal = {International Journal of Agriculture Environment and Food Sciences}, issn = {}, eissn = {2618-5946}, address = {Dicle University Faculty of Agriculture Department of Horticulture, 21280 Diyarbakir / Turkey}, publisher = {Gültekin ÖZDEMİR}, year = {2020}, volume = {4}, pages = {230 - 235}, doi = {10.31015/jaefs.2020.2.14}, title = {Homocysteine metabolism in rats with metabolic syndrome and the impacts of nigella sativa oil on some biochemical parameters}, key = {cite}, author = {Alayunt, Naci and Ustundag, Bilal} }
APA Alayunt, N , Ustundag, B . (2020). Homocysteine metabolism in rats with metabolic syndrome and the impacts of nigella sativa oil on some biochemical parameters . International Journal of Agriculture Environment and Food Sciences , 4 (2) , 230-235 . DOI: 10.31015/jaefs.2020.2.14
MLA Alayunt, N , Ustundag, B . "Homocysteine metabolism in rats with metabolic syndrome and the impacts of nigella sativa oil on some biochemical parameters" . International Journal of Agriculture Environment and Food Sciences 4 (2020 ): 230-235 <https://dergipark.org.tr/en/pub/jaefs/issue/53546/715446>
Chicago Alayunt, N , Ustundag, B . "Homocysteine metabolism in rats with metabolic syndrome and the impacts of nigella sativa oil on some biochemical parameters". International Journal of Agriculture Environment and Food Sciences 4 (2020 ): 230-235
RIS TY - JOUR T1 - Homocysteine metabolism in rats with metabolic syndrome and the impacts of nigella sativa oil on some biochemical parameters AU - Naci Alayunt , Bilal Ustundag Y1 - 2020 PY - 2020 N1 - doi: 10.31015/jaefs.2020.2.14 DO - 10.31015/jaefs.2020.2.14 T2 - International Journal of Agriculture Environment and Food Sciences JF - Journal JO - JOR SP - 230 EP - 235 VL - 4 IS - 2 SN - -2618-5946 M3 - doi: 10.31015/jaefs.2020.2.14 UR - https://doi.org/10.31015/jaefs.2020.2.14 Y2 - 2020 ER -
EndNote %0 International Journal of Agriculture Environment and Food Sciences Homocysteine metabolism in rats with metabolic syndrome and the impacts of nigella sativa oil on some biochemical parameters %A Naci Alayunt , Bilal Ustundag %T Homocysteine metabolism in rats with metabolic syndrome and the impacts of nigella sativa oil on some biochemical parameters %D 2020 %J International Journal of Agriculture Environment and Food Sciences %P -2618-5946 %V 4 %N 2 %R doi: 10.31015/jaefs.2020.2.14 %U 10.31015/jaefs.2020.2.14
ISNAD Alayunt, Naci , Ustundag, Bilal . "Homocysteine metabolism in rats with metabolic syndrome and the impacts of nigella sativa oil on some biochemical parameters". International Journal of Agriculture Environment and Food Sciences 4 / 2 (June 2020): 230-235 . https://doi.org/10.31015/jaefs.2020.2.14
AMA Alayunt N , Ustundag B . Homocysteine metabolism in rats with metabolic syndrome and the impacts of nigella sativa oil on some biochemical parameters. int. j. agric. environ. food sci.. 2020; 4(2): 230-235.
Vancouver Alayunt N , Ustundag B . Homocysteine metabolism in rats with metabolic syndrome and the impacts of nigella sativa oil on some biochemical parameters. International Journal of Agriculture Environment and Food Sciences. 2020; 4(2): 230-235.