Atopik Dermatit Tedavisinde Biyolojik İlaçlar: Literatür Taraması

Year 2024, Volume: 9 Issue: 2, 36 - 51, 16.08.2024

Furkan Çalıcıoğlu Neşecan Çalıcıoğlu Atıl Avcı Yılmaz Ulaş Ragıp Ertaş

https://doi.org/10.55694/jamer.1410278

Abstract

Atopik dermatit; kronik, kaşıntılı, inflamatuar bir deri hastalığıdır. Pediatrik dönemde ve erişkinlik döneminde görülebilen atopik dermatit; kaşıntı, kaşıntıya bağlı uyku bozuklukları, sosyal geri çekilme ve tedavi maliyetleri açısından hastanın yaşam kalitesini doğrudan etkilemektedir. Topikal tedaviler, fototerapi yöntemleri, sistemik immünsupresif ilaçlar ve biyolojik ajanlar atopik dermatit tedavisinde kullanılmaktadır. Biyolojik ajanlar; hızlı etki başlangıçları ve kaşıntının sürdürülebilir kontrolünde oldukça önemli bir rol üstlenmektedir. Semptomların kontrolünde etkili ilaçlar olmaları ve konvansiyonel immünsupresif ilaçlara göre daha az yan etkiye sahip olmaları sebebiyle biyolojik ajanlar atopik dermatit tedavisinde gelecekte daha sık kullanılabilir. Atopik dermatit tedavisi ile ilgili araştırmalar sürdükçe yeni biyolojik ilaçlar üretilmeye ve kullanılmaya devam edecektir. Atopik dermatit tedavisinde kullanılan biyolojik ajanların faz çalışmalarının sonuçlarını ve gerçek yaşam verilerini sentezleyerek paylaşmak istiyoruz. Farklı mekanizmalar üzerinden ilaçların etkilerini, vaka sonuçlarını, karşılaşılan yan etkileri, tedavi sürdürülebilirliğini ve uzun dönem risklerini bir bütün olarak ortaya koymayı ve tartışmayı amaçlıyoruz.

Keywords

Atopik, dermatit, antikorlar, monoklonal

Ethical Statement

Derleme çalışmamız Dünya Helsinki Bildirgesine ve tıp etiği kurallarına uygun olarak hazırlanmıştır.

BIOLOGICAL DRUGS IN THE TREATMENT OF ATOPIC DERMATITIS: LITERATURE REVIEW

Abstract

Atopic dermatitis is a chronic, itchy, inflammatory skin condition. Occurring in children and adults, atopic dermatitis has a direct impact on patients' quality of life in terms of itching, itch-related sleep disturbance, social withdrawal and treatment costs. Topical treatments, phototherapy methods, systemic immunosuppressive drugs and biological drugs are used in the treatment of atopic dermatitis. Biologic agents play an important role with their rapid onset of action and sustained control of pruritus. Biological drugs may be used more frequently in the treatment of atopic dermatitis in the future as they are effective in controlling symptoms and have fewer side effects than conventional immunosuppressive drugs. As research into the treatment of atopic dermatitis continues, new biologics will continue to be produced and used. We would like to summarize and share the results of phase studies and real-life data of biological drugs used in the treatment of atopic dermatitis. We aim to present and discuss the effects of the drugs through different mechanisms, case outcomes, side effects, treatment sustainability and long-term risks as a whole.

Keywords

Atopic, dermatitis, monoclonal, antibodies

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