Klotho Protein and Type 2 Diabetes Mellitus

Eda Dokumacıoğlu; Hatice Iskender

doi:10.35206/jan.1087260

TR EN

Klotho Proteini ve Tip 2 Diabetes Mellitus

Öz

Diabetes Mellitus (DM), birçok ülke tarafından epidemik bir hastalık olarak kabul edilmekte ve batı toplumlarında en önde gelen ölüm nedenlerinden biri olarak gösterilmektedir. Hastalığın gelişiminde altta yatan patofizyolojik mekanizmalar kompleks ve multifaktöriyeldir. DM sıklığı yaş ile artmakta ve bununla birlikte oksidatif stres, inflamasyon gibi olayların şiddeti de DM tanılı hastalarda artmaktadır. Yaşlanma mekanizmaları üzerinde yapılan araştırmalar sonucu yeni bir anti-aging protein olarak tanımlanan klotho (KL) proteini glukoz homeostazı ve insulin salgılanmasında önemli fonksiyonlara sahiptir. Bu derleme çalışmasında, 2002-2020 yılları arasında PubMed'de taranan dergilerde yayınlanan makalelerdeki bilgiler derlenerek KL proteini ile DM arasındaki ilişki anlatılmıştır. Sonuç olarak, KL düzeylerindeki azalma tip 2 DM ve buna bağlı olarak gelişen nefropati ve vasküler hastalıklarda önemli rol oynar.

Anahtar Kelimeler

inflamasyon , Type 2 Diabetes mellitus , Klotho , oksidatif stres

Klotho Protein and Type 2 Diabetes Mellitus

Abstract

Diabetes mellitus (DM) is considered an epidemic disease by many countries and shown as one of the leading causes of death in western societies. In the development of the disease, the underlying pathophysiological mechanisms are complex and multifactorial. The frequency of DM increases with age, and the severity of events such as oxidative stress and inflammation increases in patients diagnosed with DM. The Klotho (KL) protein, defined as a new anti-aging protein as a result of the studies on aging mechanisms and it has an important functions on glucose homeostasis and insulin secretion. In this review study, the relationship between KL protein and DM is explained by compiling the information in the articles published in PubMed indexed journals between 2002-2020. In conclusion, a decrease in KL levels plays a role in type 2 DM and the development of nephropathy and vascular diseases caused by type 2 DM.

Keywords

oxidative stress , Type 2 Diabetes mellitus , Klotho , inflammation

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Details

Primary Language

English

Subjects

-

Journal Section

Review

Authors

Eda Dokumacıoğlu ^*
0000-0002-2223-1331
Türkiye

Hatice Iskender
0000-0002-8063-4972
Türkiye

Publication Date

December 31, 2022

Submission Date

March 13, 2022

Acceptance Date

December 29, 2022

Published in Issue

Year 2022 Volume: 5 Number: 2

DOI

https://doi.org/10.35206/jan.1087260

IZ

https://izlik.org/JA44XN42XX

APA

Dokumacıoğlu, E., & Iskender, H. (2022). Klotho Protein and Type 2 Diabetes Mellitus. Journal of Apitherapy and Nature, 5(2), 133-146. https://doi.org/10.35206/jan.1087260

AMA

1.Dokumacıoğlu E, Iskender H. Klotho Protein and Type 2 Diabetes Mellitus. J.Apit.Nat. 2022;5(2):133-146. doi:10.35206/jan.1087260

Chicago

Dokumacıoğlu, Eda, and Hatice Iskender. 2022. “Klotho Protein and Type 2 Diabetes Mellitus”. Journal of Apitherapy and Nature 5 (2): 133-46. https://doi.org/10.35206/jan.1087260.

EndNote

Dokumacıoğlu E, Iskender H (December 1, 2022) Klotho Protein and Type 2 Diabetes Mellitus. Journal of Apitherapy and Nature 5 2 133–146.

IEEE

[1]E. Dokumacıoğlu and H. Iskender, “Klotho Protein and Type 2 Diabetes Mellitus”, J.Apit.Nat., vol. 5, no. 2, pp. 133–146, Dec. 2022, doi: 10.35206/jan.1087260.

ISNAD

Dokumacıoğlu, Eda - Iskender, Hatice. “Klotho Protein and Type 2 Diabetes Mellitus”. Journal of Apitherapy and Nature 5/2 (December 1, 2022): 133-146. https://doi.org/10.35206/jan.1087260.

JAMA

1.Dokumacıoğlu E, Iskender H. Klotho Protein and Type 2 Diabetes Mellitus. J.Apit.Nat. 2022;5:133–146.

MLA

Dokumacıoğlu, Eda, and Hatice Iskender. “Klotho Protein and Type 2 Diabetes Mellitus”. Journal of Apitherapy and Nature, vol. 5, no. 2, Dec. 2022, pp. 133-46, doi:10.35206/jan.1087260.

Vancouver

1.Eda Dokumacıoğlu, Hatice Iskender. Klotho Protein and Type 2 Diabetes Mellitus. J.Apit.Nat. 2022 Dec. 1;5(2):133-46. doi:10.35206/jan.1087260

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Klotho Proteini ve Tip 2 Diabetes Mellitus

Öz

Anahtar Kelimeler

Klotho Protein and Type 2 Diabetes Mellitus

Abstract

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References

Details

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Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

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