Effects of Chestnut Honey on Growth Parameters and Growth-Related Hormones in Rat

Year 2025, Volume: 8 Issue: 2, 253 - 267, 31.12.2025

Zeynep Hızal , Tuğçe Çaprazlı , Eda Nur Gözderesi Meral Kekeçoğlu

https://doi.org/10.35206/jan.1778899

Abstract

This study investigated the effects of chestnut honey on growth and development. A total of 14 Wistar albino rats were divided into two groups: the Control group (C) and the Chestnut Honey group (CH). During the 23-day experimental period, weekly measurements of body length and weight were recorded, body mass index (BMI) was calculated, and growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels were assessed. At the end of the treatment, no statistically significant differences were observed between the Chestnut Honey and Control groups in terms of body weight and body length (p = 0.355, p = 0.772, p = 0.232). Furthermore, biochemically, IGF-1 levels did not differ significantly between groups (p = 0.919), whereas GH levels were significantly reduced in the chestnut honey group compared to the control group (p < 0.001). These results indicate that chestnut honey is a safe dietary component that does not induce weight gain or adversely affect IGF-1 metabolism.

Keywords

chesnut honey , weight , height , BMI , Growth hormone , IGF-1

Ethical Statement

This study was reviewed by the Düzce University Animal Experiments Local Ethics Committee and approved ethically by decision dated May 15, 2024, numbered 2024-05-02.

Supporting Institution

Düzce University

Project Number

2025.21.09.1614

Thanks

This study was supported by Düzce University Scientific Research Projects (BAP) under project number 2025.21.09.1614.

Kestane Balının Sıçanlarda Büyüme Parametreleri ve Büyüme ile İlgili Hormonlar Üzerindeki Etkileri

Abstract

Bu çalışmada, kestane balının büyüme ve gelişme üzerindeki etkilerini araştırıldı. Toplam 14 Wistar albino sıçan, Kontrol grubu (C) ve Kestane Balı grubu (CH) olmak üzere iki gruba ayrıldı. 23 günlük deney süresi boyunca, haftalık vücut uzunluğu ve vücut ağırlığı ölçümleri kaydedilmiş, vücut kitle indeksi (BMI) hesaplanmış ve büyüme hormonu (GH) ve insülin benzeri büyüme faktörü 1 (IGF-1) düzeyleri değerlendirilmiştir. Tedavinin sonunda, kestane balı grubu ile kontrol grubu arasında vücut ağırlığı ve vücut uzunluğu açısından istatistiksel olarak anlamlı bir fark gözlenmemiştir (p = 0,355, p = 0,772, p = 0,232). Ayrıca, biyokimyasal olarak, IGF-1 düzeyleri gruplar arasında önemli ölçüde farklılık göstermezken (p = 0,919), GH düzeyleri kontrol grubuna kıyasla kestane balı grubunda önemli ölçüde azalmıştır (p < 0,001). Bu sonuçlar, kestane balının kilo alımına neden olmayan ve IGF-1 metabolizmasını olumsuz etkilemeyen güvenli bir besin bileşeni olduğunu göstermektedir.

Keywords

kestane balı , ağırlık , boy , BMI , büyüme hormonu , IGF-1

Ethical Statement

Bu çalışma, Düzce Üniversitesi Hayvan Deneyleri Yerel Etik Kurulu tarafından incelenmiş ve 15 Mayıs 2024 tarihli ve 2024-05-02 numaralı karar ile etik açıdan onaylanmıştır.

Supporting Institution

Düzce Üniversitesi

Project Number

2025.21.09.1614

Thanks

Bu çalışma, Düzce Üniversitesi Bilimsel Araştırma Projeleri (BAP) tarafından 2025.21.09.1614 numaralı proje kapsamında desteklenmiştir.

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