Effects of Chestnut Honey on Growth Parameters and Growth-Related Hormones in Rat

Zeynep Hızal; Tuğçe Çaprazlı; Eda Nur Gözderesi; Meral Kekeçoğlu

doi:10.35206/jan.1778899

EN TR

Effects of Chestnut Honey on Growth Parameters and Growth-Related Hormones in Rat

Abstract

This study investigated the effects of chestnut honey on growth and development. A total of 14 Wistar albino rats were divided into two groups: the Control group (C) and the Chestnut Honey group (CH). During the 23-day experimental period, weekly measurements of body length and weight were recorded, body mass index (BMI) was calculated, and growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels were assessed. At the end of the treatment, no statistically significant differences were observed between the Chestnut Honey and Control groups in terms of body weight and body length (p = 0.355, p = 0.772, p = 0.232). Furthermore, biochemically, IGF-1 levels did not differ significantly between groups (p = 0.919), whereas GH levels were significantly reduced in the chestnut honey group compared to the control group (p < 0.001). These results indicate that chestnut honey is a safe dietary component that does not induce weight gain or adversely affect IGF-1 metabolism.

Keywords

chesnut honey, weight, height, BMI, Growth hormone, IGF-1

Kestane Balının Sıçanlarda Büyüme Parametreleri ve Büyüme ile İlgili Hormonlar Üzerindeki Etkileri

Abstract

Bu çalışmada, kestane balının büyüme ve gelişme üzerindeki etkilerini araştırıldı. Toplam 14 Wistar albino sıçan, Kontrol grubu (C) ve Kestane Balı grubu (CH) olmak üzere iki gruba ayrıldı. 23 günlük deney süresi boyunca, haftalık vücut uzunluğu ve vücut ağırlığı ölçümleri kaydedilmiş, vücut kitle indeksi (BMI) hesaplanmış ve büyüme hormonu (GH) ve insülin benzeri büyüme faktörü 1 (IGF-1) düzeyleri değerlendirilmiştir. Tedavinin sonunda, kestane balı grubu ile kontrol grubu arasında vücut ağırlığı ve vücut uzunluğu açısından istatistiksel olarak anlamlı bir fark gözlenmemiştir (p = 0,355, p = 0,772, p = 0,232). Ayrıca, biyokimyasal olarak, IGF-1 düzeyleri gruplar arasında önemli ölçüde farklılık göstermezken (p = 0,919), GH düzeyleri kontrol grubuna kıyasla kestane balı grubunda önemli ölçüde azalmıştır (p < 0,001). Bu sonuçlar, kestane balının kilo alımına neden olmayan ve IGF-1 metabolizmasını olumsuz etkilemeyen güvenli bir besin bileşeni olduğunu göstermektedir.

Keywords

kestane balı, ağırlık, boy, BMI, büyüme hormonu, IGF-1

Supporting Institution

Düzce University

Project Number

2025.21.09.1614

Ethical Statement

This study was reviewed by the Düzce University Animal Experiments Local Ethics Committee and approved ethically by decision dated May 15, 2024, numbered 2024-05-02.

Thanks

This study was supported by Düzce University Scientific Research Projects (BAP) under project number 2025.21.09.1614.

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Details

Primary Language

English

Subjects

Food Engineering

Journal Section

Research Article

Authors

Zeynep Hızal
0009-0001-4419-181X
Türkiye

Tuğçe Çaprazlı
0000-0001-9109-0969
Türkiye

Eda Nur Gözderesi This is me
0009-0003-5115-6638
Türkiye

Meral Kekeçoğlu ^*
0000-0002-2564-8343
Türkiye

Publication Date

December 31, 2025

Submission Date

September 5, 2025

Acceptance Date

October 9, 2025

Published in Issue

Year 2025 Volume: 8 Number: 2

DOI

https://doi.org/10.35206/jan.1778899

IZ

https://izlik.org/JA59RN97FD

APA

Hızal, Z., Çaprazlı, T., Gözderesi, E. N., & Kekeçoğlu, M. (2025). Effects of Chestnut Honey on Growth Parameters and Growth-Related Hormones in Rat. Journal of Apitherapy and Nature, 8(2), 253-267. https://doi.org/10.35206/jan.1778899

AMA

1.Hızal Z, Çaprazlı T, Gözderesi EN, Kekeçoğlu M. Effects of Chestnut Honey on Growth Parameters and Growth-Related Hormones in Rat. J.Apit.Nat. 2025;8(2):253-267. doi:10.35206/jan.1778899

Chicago

Hızal, Zeynep, Tuğçe Çaprazlı, Eda Nur Gözderesi, and Meral Kekeçoğlu. 2025. “Effects of Chestnut Honey on Growth Parameters and Growth-Related Hormones in Rat”. Journal of Apitherapy and Nature 8 (2): 253-67. https://doi.org/10.35206/jan.1778899.

EndNote

Hızal Z, Çaprazlı T, Gözderesi EN, Kekeçoğlu M (December 1, 2025) Effects of Chestnut Honey on Growth Parameters and Growth-Related Hormones in Rat. Journal of Apitherapy and Nature 8 2 253–267.

IEEE

[1]Z. Hızal, T. Çaprazlı, E. N. Gözderesi, and M. Kekeçoğlu, “Effects of Chestnut Honey on Growth Parameters and Growth-Related Hormones in Rat”, J.Apit.Nat., vol. 8, no. 2, pp. 253–267, Dec. 2025, doi: 10.35206/jan.1778899.

ISNAD

Hızal, Zeynep - Çaprazlı, Tuğçe - Gözderesi, Eda Nur - Kekeçoğlu, Meral. “Effects of Chestnut Honey on Growth Parameters and Growth-Related Hormones in Rat”. Journal of Apitherapy and Nature 8/2 (December 1, 2025): 253-267. https://doi.org/10.35206/jan.1778899.

JAMA

1.Hızal Z, Çaprazlı T, Gözderesi EN, Kekeçoğlu M. Effects of Chestnut Honey on Growth Parameters and Growth-Related Hormones in Rat. J.Apit.Nat. 2025;8:253–267.

MLA

Hızal, Zeynep, et al. “Effects of Chestnut Honey on Growth Parameters and Growth-Related Hormones in Rat”. Journal of Apitherapy and Nature, vol. 8, no. 2, Dec. 2025, pp. 253-67, doi:10.35206/jan.1778899.

Vancouver

1.Zeynep Hızal, Tuğçe Çaprazlı, Eda Nur Gözderesi, Meral Kekeçoğlu. Effects of Chestnut Honey on Growth Parameters and Growth-Related Hormones in Rat. J.Apit.Nat. 2025 Dec. 1;8(2):253-67. doi:10.35206/jan.1778899

e-ISSN: 2667-4734 Publication Model: Continuous Publication Citation Indexes: TR Dizin

Effects of Chestnut Honey on Growth Parameters and Growth-Related Hormones in Rat

Abstract

Keywords

Kestane Balının Sıçanlarda Büyüme Parametreleri ve Büyüme ile İlgili Hormonlar Üzerindeki Etkileri

Abstract

Keywords

Supporting Institution

Project Number

Ethical Statement

Thanks

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

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