DIAGNOSTIC VALUE OF SYSTEMIC IMMUNE–INFLAMMATION INDEX (SIII) IN ACUTE ISCHEMIC STROKE

Abstract

Background: Calculated based on platelet, neutrophil and lymphocyte counts, the systemic immune-inflammation index is thought to be associated with many malignancies in the literature. Despite the existing investigations on its diagnostic value, there have been no clear results reported regarding its diagnostic value in stroke patients. The current study is therefore intended to demonstrate the diagnostic value of the systemic immune-inflammation index and its prognostic value in cases of acute ischemic stroke. Materials and Methods: A total of 150 cases of acute stroke and a control group of 150 individuals were retrospectively examined. The data recorded for each case included age, gender, history, vital findings, NIHSS, SIII, and outcome. Results: In the current study, the group of stroke patients had significantly higher SIII than the control group. According to the diagnostic examinations, in stroke, the diagnostic value of SIII was greater than that of neutrophil-to-lymphocyte ratio at a statistically significant level. The present study also found that, compared to the SIII, the (Lymphocyte x Platelet)/Neutrophil ratio (called the novel SIII) had a higher statistical significance in diagnosing the stroke and predicting early hospital mortality. Conclusions: The SIII can be a good marker for both diagnostic evaluation and for predicting early hospital mortality in stroke cases. Additionally, it is approved to be a useful index since it can be calculated inexpensively and easily.

Keywords

• Ischemic Stroke
• Systemic immune-inflammation index
• Emergency Department
• Prognosis

AKUT İSKEMİK İNMEDE SİSTEMİK İMMÜN-İNFLAMASYON ENDEKSİNİN (SIII) TANISAL DEĞERLİLİĞİ

Abstract

Giriş: Trombosit, nötrofil ve lenfosit sayılarına göre hesaplanan sistemik immün-enflamasyon indeksinin literatürde birçok malignite ile ilişkili olduğu düşünülmektedir. Tanısal değeri ile ilgili mevcut araştırmalara rağmen inme hastalarında tanısal değeri ile ilgili net sonuçlar bildirilmemiştir. Bu nedenle mevcut çalışma, akut iskemik inme vakalarında sistemik immün-enflamasyon indeksinin tanısal değerini ve bunun prognostik değerini göstermeyi amaçlamaktadır. Gereç ve Yöntemler: Toplam 150 akut inme olgusu ve 150 kişilik kontrol grubu retrospektif olarak incelendi. Her vaka için kaydedilen veriler yaş, cinsiyet, öykü, hayati bulgular, NIHSS, SIII ve sonucu içeriyordu. Bulgular: Mevcut çalışmada, inmeli hasta grubunda kontrol grubuna göre anlamlı olarak daha yüksek SIII vardı. Tanısal incelemelere göre inmede SIII'ün tanısal değeri nötrofil/lenfosit oranından istatistiksel olarak anlamlı düzeyde daha yüksekti. Bu çalışma ayrıca, SIII ile karşılaştırıldığında, (Lenfosit x Trombosit)/Nötrofil oranının (yeni SIII olarak adlandırılır) inme tanısında ve erken hastane mortalitesini tahmin etmede daha yüksek bir istatistiksel öneme sahip olduğunu bulmuştur. Sonuçlar: SIII, inme vakalarında hem tanısal değerlendirme hem de erken hastane mortalitesini öngörmek için iyi bir belirteç olabilir. Ayrıca ucuz ve kolay hesaplanabilmesi nedeniyle faydalı bir parametre olduğunu düşünmekteyiz.

Keywords

• Ischemic Stroke
• Systemic immune-inflammation index
• Emergency Department
• Prognosis

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