Topikal Antiglokomatöz Damlaların Kronik Kullanımı İle Oküler Demodeks Enfestasyonu Arasındaki İlişkinin Araştırılması

Year 2023, , 225 - 228, 22.03.2023

Adem Soydan , Abdulgani Kaymaz , Erol Ayaz , Kerem Yaman , Mücahit Çakmak , Abdullah Bayrak , Metin Okşar

https://doi.org/10.16899/jcm.1233866

Abstract

AMAÇ : Topikal antiglokomatöz damlaların kronik kullanımı ile oküler Demodeks infestasyonu arasındaki ilişkiyi araştırmak.
GEREÇ VE YÖNTEM: Bu kesitsel çalışmaya 55 bilateral glokomlu hasta ve 58 kontrol olgusunun her iki gözü olmak üzere toplam 226 göz dahil edildi. Tüm katılımcılardan alt ve üst göz kapaklarından 2'şer adet olmak üzere toplam 8 adet kirpik alındı ve örnekler analiz için parazitoloji laboratuvarına gönderildi.
BULGULAR: Çalışmaya katılanların yaş ortalaması glokom hastalarında 66,48±15,19, kontrol grubunda 64,76±10,89 idi. Alınan kirpik örneklerinin analizinden, oküler Demodeks glokomlu hastaların %55'inde pozitif ve %45'inde negatifti. Kontrol grubunda Demodeks %34 pozitif, %66 negatifti. Demodeks enfestasyon pozitifliği glokomlu hastalarda istatistiksel olarak anlamlı derecede yüksek saptandı (p= 0,042).
SONUÇ: Oküler Demodeks infestasyon oranı yaşla birlikte artmaktadır ve kronik topikal antiglokomatöz damla kullanımı ile bu oranın daha da arttığı tahmin edilmektedir.

Keywords

Antiglaucomatous Drops, Demodex Folliculorum, Glaucoma, Ocular Demodex

Supporting Institution

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Project Number

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Investigation of the Relationship Between Chronic Use of Topical Antiglaucomatous Drops and Ocular Demodex Infestation

Abstract

AIM : To investigate the relationship between chronic use of topical antiglaucomatous drop and ocular Demodex infestation.
MATERIAL AND METHOD: This cross-sectional study included a total of 226 eyes, as both eyes of 55 patients with bilateral glaucoma and 58 control subjects. A total of 8 eyelashes, 2 each from the lower and upper eyelids of all the study participants, were taken and the samples were sent to the parasitology laboratory for analysis.
RESULTS: The mean age of the study participants was 66.48±15.19 years in the glaucoma patients, and 64.76±10.89 years in the control group. From analysis of the eyelash samples taken, ocular Demodex was positive in 55% of patients with glaucoma, and negative in 45%. In the control group, Demodex was positive in 34% and negative in 66%. Demodex infestation positivity was determined to be statistically significantly higher in patients with glaucoma (p= 0.042).
CONCLUSION: The rate of ocular Demodex infestation increases with age, and it is estimated that this rate is further increased by the use of chronic topical antiglaucomatous drops.

Keywords

Antiglaucomatous Drops, Demodex Folliculorum, Glaucoma, Ocular Demodex

Project Number

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References

• 1. Lusthaus J, Goldberg I. Current management of glaucoma. Med J Aust 2019;210:180-7.
• 2. Miller PE, Eaton JS. Medical anti‐glaucoma therapy: Beyond the drop. Vet Ophthalmol 2021;24:2-15.
• 3. Leung EW, Medeiros FA, Weinreb RN. Prevalence of ocular surface disease in glaucoma patients. J. Glaucoma 2008;17:350-5.
• 4. Pólit F, Pólit A, Molano N. Low prevalence of eyelid infestation by Demodex folliculorum in patients with primary open-angle glaucoma treated with prostaglandin analogues. Rev Me Oftalmol 2018;92:122-30.
• 5. Stewart WC, Stewart JA, Nelson LA. Ocular surface disease in patients with ocular hypertension and glaucoma. Curr. Eye Res. 2011;36:391-8.
• 6. Geyer O, Bottone EJ, Podos SM, Schumer RA, Asbell PA. Microbial contamination of medications used to treat glaucoma. Br J Ophthalmol. 1995;79:376-9.
• 7. Azari AA, Arabi A. Conjunctivitis: a systematic review. J Ophthalmic Vis Res. 2020;15:372.
• 8. Zhang AC, Muntz A, Wang MT, Craig JP, Downie LE. Ocular Demodex: a systematic review of the clinical literature. Ophthalmic Physiol Opt. 2020;40:389-432.
• 9. Lai L-J, Chen VC-H, Yang Y-H, Kao K-L, Chen K-J, Wang Y-C, et al. Mycoplasma infection and ocular surface diseases: a nationwide cohort study. Sci. Rep. 2021;11:1-6.
• 10. Schwartz GF, Kotak S, Mardekian J, Fain JM. Incidence of new coding for dry eye and ocular infection in open-angle glaucoma and ocular hypertension patients treated with prostaglandin analogs: retrospective analysis of three medical/pharmacy claims databases. BMC Ophthalmol. 2011;11:1-10.
• 11. Baudouin C, Kolko M, Melik-Parsadaniantz S, Messmer EM. Inflammation in Glaucoma: From the back to the front of the eye, and beyond. Prog Retin Eye Res. 2021;83:100916.
• 12. Sędzikowska A, Osęka M, Skopiński P. The impact of age, sex, blepharitis, rosacea and rheumatoid arthritis on Demodex mite infection. Arch Med Sci. 2018;14:353-6.
• 13. Bonnar E, Dowling S, Eustace P. A survey of blepharitis in pre-operative cataract patients. Eur J Implant Ref Surg. 1994;6:87-92.
• 14. English FP, Nutting WB. Demodicosis of ophthalmic concern. Am. J. Ophthalmol. 1981;91:362-72.