Retrospective Evaluation of Pediatric Patients Hospitalized with Brucellosis: Single Center Study in Istanbul

Abstract

Aim: Brucellosis is a zoonotic disease and mainly develops as a result of consuming products of infected animals such as cattle, sheep and pigs. Material-Methods: Pediatric patients under the age of 18 who were hospitalized with a diagnosis of brucellosis in a third-level city hospital were included in the study. Serology titer ≥1:160 and/or Brucella spp in blood culture growth was determined as the diagnostic criterion for the diagnosis of brucellosis. Results: Of the 35 pediatric patients diagnosed with brucellosis, 22 were boys and 13 were girls, and the average age was determined as 154.2 ± 53.1 months (25-214). Hospital admission complaints were determined in order of frequency as follows; joint pain (51.4%), fever (31.4%), headache (17.1%) and abdominal pain (5.2%). Eleven of the patients (31.4%) had polyarthralgia and 7 (20%) had monoarthralgia. The most common physical examination findings were hepatomegaly (48.6%) and splenomegaly (40%), respectively. Joint involvement was detected in 17.1% of the patients. Sacroiliac joint involvement was reported in 3 (8.6%) patients, ankle joint involvement in 2 (5.7%) patients, and knee joint involvement in 1 (2.9%) patient. Anemia (60%) was the most common hematological finding. The average hemoglobin value was determined as 12.5±1.44 (10.2-15.9) g/dl. When patients are compared in terms of joint involvement; neutrophil count and treatment duration were found to be statistically higher in patients with joint involvement (p<0.05). Conclusion: Brucellosis is a zoonotic disease that is endemic in our country, affects all age groups, and can cause complications and relapses, and continues to be a serious public health problem for our country.

Keywords

• Brucella
• child
• zoonotic disease

Ethical Statement

All of the authors declare that they have all participated in the design, execution, and analysis of the paper, and that they have approved the final version. Additionally, there are no conflicts of interest in connection with this paper, and the material described is not under publication or consideration for publication elsewhere. The article submitted has not been published in any other medium and shall not be submitted to a different scientific journal or any other publication. The study did not receive any funding.

İstanbul'da Hastaneye Yatırılan Pediatrik Brusellozlu Hastaların Retrospektif Değerlendirmesi: Tek Merkezli Bir Çalışma

Abstract

Giriş: Bruselloz, zoonotik bir hastalık olup, başlıca enfekte sığır, koyun ve domuz gibi hayvanların ürünlerinin tüketilmesi sonucu gelişir. Materyal-Metod: Üçüncü düzey bir şehir hastanesinde bruselloz tanısıyla hastaneye yatan 18 yaş altı çocuk hastalar çalışmaya dahil edildi. Seroloji titresinin ≥1:160 olması ve/veya kan kültüründe Brucella spp. üremesi bruselloz tanısı için tanı kriteri olarak belirlendi. Bulgular: 35 bruselloz tanılı çocuk hastanın 22’si erkek, 13’ü kız idi ve ortalama yaş 154.2 ± 53.1ay (25-214) olarak belirlendi. Hastane başvuru şikayetleri sıklık sırasında göre şöyle belirlendi; eklem ağrısı (%51.4), ateş (%31.4), baş ağrısı (%17.1) ve karın ağrısı (%5.2). Hastaların 11’inde (%31.4) poliartralji, 7’sinde (%20) ise monoartralji şikayeti mevcut idi. En sık saptanan fizik muayene bulguları sırasıyla hepatomegali (%48.6) ve splenomegali (%40) olarak belirlendi. Hastaların %17.1'inde eklem tutulumu saptandı. 3 (%8.6) hastada sakroiliak eklem, 2 (%5.7) hastada ayak bileği eklemi, 1(%2.9) hastada ise diz eklem tutulumu raporlandı. Anemi (%60) en sık saptanan hematolojik bulgu idi. Hemoglobin değeri ortalama 12,5±1,44 (10,2-15,9) g/dl olarak saptandı. Hastalar eklem tutulumu açısından karşılaştırıldığında; eklem tutulumu olan hastalarda nötrofil sayısı ve tedavi süresi istatistiksel olarak daha yüksek bulundu (p<0,05). Tartışma: Bruselloz ülkemizde endemik olan, tüm yaş gruplarını etkileyen, komplikasyon ve nükslere neden olabilen zoonotik bir hastalıktır ve ülkemiz için ciddi bir halk sağlığı sorunu olmaya devam etmektedir.

Keywords

• Brusella
• çocuk
• zoonotik hastalık

Ethical Statement

Yazarların tamamı makalenin tasarımına, yürütülmesine ve analizine katıldıklarını ve son halini onayladıklarını beyan ederler. Ek olarak, bu makaleyle bağlantılı olarak herhangi bir çıkar çatışması yoktur ve açıklanan materyal yayın aşamasında değildir veya başka bir yerde yayınlanmak üzere değerlendirilmemektedir. Gönderilen makale başka bir mecrada yayınlanmamış olup, farklı bir bilimsel dergi veya başka bir yayına sunulmayacaktır. Çalışma herhangi bir finansman almadı.

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