Retrospective Evaluation of Pediatric Patients Hospitalized with Brucellosis: Single Center Study in Istanbul

Öz

Aim: Brucellosis is a zoonotic disease and mainly develops as a result of consuming products of infected animals such as cattle, sheep and pigs. Material-Methods: Pediatric patients under the age of 18 who were hospitalized with a diagnosis of brucellosis in a third-level city hospital were included in the study. Serology titer ≥1:160 and/or Brucella spp in blood culture growth was determined as the diagnostic criterion for the diagnosis of brucellosis. Results: Of the 35 pediatric patients diagnosed with brucellosis, 22 were boys and 13 were girls, and the average age was determined as 154.2 ± 53.1 months (25-214). Hospital admission complaints were determined in order of frequency as follows; joint pain (51.4%), fever (31.4%), headache (17.1%) and abdominal pain (5.2%). Eleven of the patients (31.4%) had polyarthralgia and 7 (20%) had monoarthralgia. The most common physical examination findings were hepatomegaly (48.6%) and splenomegaly (40%), respectively. Joint involvement was detected in 17.1% of the patients. Sacroiliac joint involvement was reported in 3 (8.6%) patients, ankle joint involvement in 2 (5.7%) patients, and knee joint involvement in 1 (2.9%) patient. Anemia (60%) was the most common hematological finding. The average hemoglobin value was determined as 12.5±1.44 (10.2-15.9) g/dl. When patients are compared in terms of joint involvement; neutrophil count and treatment duration were found to be statistically higher in patients with joint involvement (p<0.05). Conclusion: Brucellosis is a zoonotic disease that is endemic in our country, affects all age groups, and can cause complications and relapses, and continues to be a serious public health problem for our country.

Anahtar Kelimeler

• Brucella
• child
• zoonotic disease

İstanbul'da Hastaneye Yatırılan Pediatrik Brusellozlu Hastaların Retrospektif Değerlendirmesi: Tek Merkezli Bir Çalışma

Öz

Giriş: Bruselloz, zoonotik bir hastalık olup, başlıca enfekte sığır, koyun ve domuz gibi hayvanların ürünlerinin tüketilmesi sonucu gelişir. Materyal-Metod: Üçüncü düzey bir şehir hastanesinde bruselloz tanısıyla hastaneye yatan 18 yaş altı çocuk hastalar çalışmaya dahil edildi. Seroloji titresinin ≥1:160 olması ve/veya kan kültüründe Brucella spp. üremesi bruselloz tanısı için tanı kriteri olarak belirlendi. Bulgular: 35 bruselloz tanılı çocuk hastanın 22’si erkek, 13’ü kız idi ve ortalama yaş 154.2 ± 53.1ay (25-214) olarak belirlendi. Hastane başvuru şikayetleri sıklık sırasında göre şöyle belirlendi; eklem ağrısı (%51.4), ateş (%31.4), baş ağrısı (%17.1) ve karın ağrısı (%5.2). Hastaların 11’inde (%31.4) poliartralji, 7’sinde (%20) ise monoartralji şikayeti mevcut idi. En sık saptanan fizik muayene bulguları sırasıyla hepatomegali (%48.6) ve splenomegali (%40) olarak belirlendi. Hastaların %17.1'inde eklem tutulumu saptandı. 3 (%8.6) hastada sakroiliak eklem, 2 (%5.7) hastada ayak bileği eklemi, 1(%2.9) hastada ise diz eklem tutulumu raporlandı. Anemi (%60) en sık saptanan hematolojik bulgu idi. Hemoglobin değeri ortalama 12,5±1,44 (10,2-15,9) g/dl olarak saptandı. Hastalar eklem tutulumu açısından karşılaştırıldığında; eklem tutulumu olan hastalarda nötrofil sayısı ve tedavi süresi istatistiksel olarak daha yüksek bulundu (p<0,05). Tartışma: Bruselloz ülkemizde endemik olan, tüm yaş gruplarını etkileyen, komplikasyon ve nükslere neden olabilen zoonotik bir hastalıktır ve ülkemiz için ciddi bir halk sağlığı sorunu olmaya devam etmektedir.

Anahtar Kelimeler

• Brusella
• çocuk
• zoonotik hastalık

Kaynakça

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