Ektopik Gebelik ile Normal İntrauterin Gebelik Arasında Tam Kan Sayımı Parametrelerinin Karşılaştırılması

Abstract

Öz Amaç: Bu çalışmada, ektopik gebelik ile normal intrauterin gebelik hastaları arasındaki tam kan sayımı parametrelerinin karşılaştırılması ve inflamasyon temelli indekslerin ektopik gebeliğin erken ayırıcı tanısındaki potansiyel yararının değerlendirilmesi amaçlandı. Gereç ve Yöntem: Bu retrospektif çalışmaya, Aralık 2018 ile Ocak 2022 tarihleri arasında Aksaray Eğitim ve Araştırma Hastanesi Kadın Hastalıkları ve Doğum Kliniğine başvuran 39 ektopik gebelik ve 51 normal intrauterin gebelik olgusu dahil edildi. Demografik özellikler, tam kan sayımı parametreleri ve türetilmiş inflamatuvar indeksler [nötrofil/lenfosit oranı (NLR), trombosit/lenfosit oranı ve lenfosit/monosit oranı] gruplar arasında karşılaştırıldı. Anlamlı farklılık gösteren parametreler için ROC eğrisi analizi yapıldı. Bulgular: Başvuru anındaki gestasyonel yaş ektopik gebelik grubunda anlamlı olarak daha düşüktü (p<0.001). Nötrofil sayısı (medyan 4.78'e karşı 6.44 ×10³/µL; p=0.023) ve NLR (medyan 2.28'e karşı 2.72; p=0.013) ektopik gebelik grubunda anlamlı olarak daha düşüktü. ROC analizinde eğri altında kalan alan NLR için 0.654 (p=0.013), nötrofil sayısı için ise 0.641 (p=0.023) bulundu. Optimal kesim değerlerinde özgüllük sırasıyla %78 ve %82 idi. Sonuç: Ektopik gebeliği olan kadınlarda nötrofil sayısı ve NLR, normal intrauterin gebeliği olan kadınlara göre anlamlı olarak daha düşüktü. Bu ucuz ve kolay ulaşılabilir parametreler, şüpheli ektopik gebeliğin ilk değerlendirilmesinde destekleyici belirteçler olarak kullanılabilir; ancak ayırt edici performansları sınırlıdır ve tek başına tanısal belirteç olarak kullanılmamalıdır.

Keywords

• Ektopik gebelik
• nötrofil/lenfosit oranı
• trombosit/lenfosit oranı
• inflamasyon
• tam kan sayımı

Supporting Institution

yok

Ethical Statement

Bu çalışma protokolü, Aksaray Üniversitesi Tıp Fakültesi Klinik Araştırmalar Etik Kurulu tarafından 2022/13-02 protokol numarası ile onaylanmış olup, çalışma Helsinki Bildirgesi ve İyi Klinik Uygulamaları ilkelerine uygun olarak yürütülmüştür.

Thanks

yok

Comparison of Complete Blood Count Parameters Between Ectopic Pregnancy and Normal Intrauterine Pregnancy

Abstract

Abstract Objectives: This study aimed to compare complete blood count parameters between patients with ectopic pregnancy and those with normal intrauterine pregnancy and to evaluate the potential utility of inflammation-based indices in the early differential diagnosis of ectopic pregnancy. Materials and methods: This retrospective study included 39 patients diagnosed with ectopic pregnancy and 51 with normal intrauterine pregnancy who presented to the Department of Obstetrics and Gynecology of Aksaray Training and Research Hospital between December 2018 and January 2022. Demographic characteristics, complete blood count parameters, and derived inflammatory indices, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio and lymphocyte-to-monocyte ratio, were compared between groups. Receiver operating characteristic (ROC) curve analysis was performed for parameters showing significant differences. Results: Gestational age at presentation was significantly lower in the ectopic pregnancy group (p<0.001). Neutrophil count (median 4.78 vs. 6.44 ×10³/µL; p=0.023) and NLR (median 2.28 vs. 2.72; p=0.013) were significantly lower in the ectopic pregnancy group. ROC analysis showed an area under the curve of 0.654 (p=0.013) for NLR and 0.641 (p=0.023) for neutrophil count. At the optimal cut-off values, the corresponding specificities were 78% and 82%, respectively. Conclusions: Neutrophil count and NLR were significantly lower in women with ectopic pregnancy than in those with normal intrauterine pregnancy. Although these inexpensive and readily available parameters may serve as supportive markers during the initial evaluation of suspected ectopic pregnancy, their discriminative performance was modest and they should not be used as standalone diagnostic markers.

Keywords

• Ectopic pregnancy
• neutrophil-to-lymphocyte ratio
• platelet-to-lymphocyte ratio
• inflammation
• complete blood count

Supporting Institution

None

Ethical Statement

This study protocol was approved by Clinical Research Ethical Committee of Aksaray University Faculty of Medicine with a protocol number of 2022/13-02 and conducted in accordance with the Declaration of Helsinki and Good Clinical Practices.

Thanks

None

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