A Potential Biomarker MicroRNAs in the Diagnosis of Some Psychiatric and Neurodegenerative Disorders

Abstract

MicroRNAs (miRNAs) are a large endogenous, non-coding RNA class of 19-25 nucleotides. Mature miRNAs regulate target gene expression at both transcriptional and translational levels. As a current area of interest in molecular diagnostic research, microRNAs (miRNAs) have recently been shown to be effective circulatory biomarkers for many diseases. Major depressive disorder, Bipolar disorder, Schizophrenia, Obsessive compulsive disorder, Alzheimer's disease and Parkinson's disease are among the most common psychiatric and neurodegenerative disorders known to be a serious public health problem in terms of morbidity, mortality and functional handicap. MicroRNAs are aware of the events occurring in the cell as normal mechanical, physical and biochemical functions due to many psychiatric and other medical diseases, and are very promising as a biomarker for emerging disorders and neuropathological changes.

Keywords

• Biomarker
• miRNA
• psychiatry
• neurodegenerative disorder

Bazı Psikiyatrik ve Nörodejeneratif Bozuklukların Tanısında Potansiyel Bir Biyobelirteç MikroRNA’ ların İncelenmesi

Abstract

Mikro Ribonükleik asitler (miRNA'lar) 19-25 nükleotitin büyük bir endojen, kodlayıcı olmayan RNA sınıfıdır. Olgun miRNA'lar hedef gen ekspresyonunu hem transkripsiyonel hem de translasyonel seviyelerde düzenler. Moleküler teşhis araştırmalarına yönelik güncel bir ilgi alanı olarak, mikroRNA'ların (miRNA'ların) son zamanlarda birçok hastalık için etkili dolaşım biyobelirteçleri olduğu gösterilmiştir. Majör depresif bozukluk, Bipolar bozukluk, Şizofreni, Obsesif kompulsif bozukluk, Alzheimer hastalığı ve Parkinson hastalığı günümüzde morbidite, mortalite ve fonksiyonel handikap açısından ciddi bir halk sağlığı sorunu oluşturduğu bilinen en yaygın psikiyatrik ve nörodejeneratif bozukluklar arasındadır. MikroRNA’lar psikiyatrik ve diğer tıbbi birçok hastalık nedeniyle normal mekanik, fiziksel ve biyokimyasal işlevler olarak hücre içinde gerçekleşen olaylardan haberdar olup, ortaya çıkan bozukluklar ve nöropatolojik değişiklikler için bir biyobelirteç olma bakımından oldukça umut vadetmektedir.

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