Is higher mean platelet volume an additional predictive marker of oligohydramnios and polyhydramnios?

Year 2019, Volume: 9 Issue: 3, 209 - 213, 30.09.2019

Neriman Çetin Benli , Sibel Mutlu , Abdülkerim Yıldız , Ali Ramazan Benli

https://doi.org/10.16899/jcm.605491

Abstract

Objectives:
Amniotic fluid abnormalities are the
leading cause of fetal morbidity and mortality. The aim of this study
was to investigate whether prepartum mean platelet volume (MPV) is associated
with and a predictable marker for oligohydramnios
(OHA)
and polyhydramnios (PHA).

Materials and Methods: In
this retrospective study, an examination was made of the records of patients
who were monitored and gave birth at Karabuk Training and Research Hospital
Gynecology and Obstetrics Clinic in 2014-2015. Patients with isolated OHA and
PHA were included in the study group and those with normal amnion fluid volume
(AFV) in the control group.  A record was
made of age, obstetric and clinical history, smoking, alcohol consumption,
laboratory test results and ultrasonography reports in the third trimester of
the pregnancy.

Results: A
total of 284 pregnant women were included in the study. The MPV levels of the
OHA and PHA groups were significantly higher than those of the normal group
(p=0.000). There was no significant difference was observed between the OHA and
PHA groups (p=0.20). MPV>8.4 accurately differentiated AFV (AUC:68.8%, sensitivity:78.6%,
specificity:59.1%). MPV>8.0 accurately differentiated OHA (AUC:67.1%,
sensitivity:84.4%, specificity:50.0%). MPV>8.5 accurately
differentiated PHA (AUC:70.2%,
sensitivity:79.0%, specificity:61.4%).

Conclusion: The result of the current study shows that
screening MPV has a predictive value for OHA and PHA in pregnancies without
complications or fetal anomaly.

Keywords

Mean Platelet Volume, Oligohydramnios, Polyhydramnios, Amniotic Fluid

Yüksek ortalama trombosit hacmi oligohidramnios ve polihidramnios için ek bir prediktif belirteç midir?

Abstract

Amaç:
Amniyotik sıvı anomalileri, fetal
morbidite ve mortalitenin önde gelen nedenleridir. Bu çalışmanın amacı,
prepartum ortalama trombosit hacminin (MPV), oligohidramnios (OHA) ve
polihidramnios (PHA) ile ilişkisini inceleyerek prediktif bir marker olup
olmadığını araştırmaktır.

Gereç
ve Yöntem: Bu
retrospektif çalışmada, 2014-2015 yılları arasında Karabük Eğitim ve Araştırma
Hastanesi Kadın Hastalıkları ve Doğum Kliniği'nde izlenen ve doğum yapan
hastaların kayıtları incelenmiştir. İzole OHA ve PHA'lı hastalar çalışma
grubuna, normal amniyon sıvısı hacmine (AFV) sahip hastalar ise kontrol grubuna
dahil edildi. Gebeliğin üçüncü trimesterinde yaş, obstetrik ve klinik öykü,
sigara kullanımı, alkol tüketimi, laboratuvar test sonuçları ve ultrasonografi
rapor sonuçları kaydedildi.

Bulgular: Çalışmaya
toplam 284 gebe dahil edildi. OHA ve PHA gruplarının MPV seviyeleri kontrol
grubuna göre anlamlı derecede yüksekti (p<0.05). OHA ve PHA grupları
arasındaistatistiksel olarak anlamlı fark görülmedi (p>0.05). MPV> 8.4,
AFV'yi doğru bir şekilde farklılaştırdı (AUC:% 68.8, duyarlılık:% 78.6,
özgüllük:% 59.1). MPV> 8.0, OHA'yı doğru şekilde farklılaştırdı (AUC:% 67.1,
duyarlılık:% 84.4, özgüllük:% 50.0). MPV> 8.5, PHA'yı doğru bir şekilde
farklılaştırdı (AUC:% 70.2, duyarlılık:% 79.0, özgüllük:% 61.4).

Tartışma: Bu
çalışmanın sonuçları; MPV taramasının komplikasyon veya fetal anomali olmayan
gebeliklerde OHA ve PHA için prediktif bir değere sahip olduğunu
göstermektedir.

Keywords

Ortalama trombosit hacmi, Oligohidramnios, Polihidramnios, Amniyotik sıvı

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