Yıl 2019, Cilt 9 , Sayı 3, Sayfalar 209 - 213 2019-09-30

Yüksek ortalama trombosit hacmi oligohidramnios ve polihidramnios için ek bir prediktif belirteç midir?
Is higher mean platelet volume an additional predictive marker of oligohydramnios and polyhydramnios?

Neriman Çetin Benli [1] , Sibel Mutlu [2] , Abdülkerim Yıldız [3] , Ali Ramazan Benli [4]


Amaç: Amniyotik sıvı anomalileri, fetal morbidite ve mortalitenin önde gelen nedenleridir. Bu çalışmanın amacı, prepartum ortalama trombosit hacminin (MPV), oligohidramnios (OHA) ve polihidramnios (PHA) ile ilişkisini inceleyerek prediktif bir marker olup olmadığını araştırmaktır.

Gereç ve Yöntem: Bu retrospektif çalışmada, 2014-2015 yılları arasında Karabük Eğitim ve Araştırma Hastanesi Kadın Hastalıkları ve Doğum Kliniği'nde izlenen ve doğum yapan hastaların kayıtları incelenmiştir. İzole OHA ve PHA'lı hastalar çalışma grubuna, normal amniyon sıvısı hacmine (AFV) sahip hastalar ise kontrol grubuna dahil edildi. Gebeliğin üçüncü trimesterinde yaş, obstetrik ve klinik öykü, sigara kullanımı, alkol tüketimi, laboratuvar test sonuçları ve ultrasonografi rapor sonuçları kaydedildi.

Bulgular: Çalışmaya toplam 284 gebe dahil edildi. OHA ve PHA gruplarının MPV seviyeleri kontrol grubuna göre anlamlı derecede yüksekti (p<0.05). OHA ve PHA grupları arasındaistatistiksel olarak anlamlı fark görülmedi (p>0.05). MPV> 8.4, AFV'yi doğru bir şekilde farklılaştırdı (AUC:% 68.8, duyarlılık:% 78.6, özgüllük:% 59.1). MPV> 8.0, OHA'yı doğru şekilde farklılaştırdı (AUC:% 67.1, duyarlılık:% 84.4, özgüllük:% 50.0). MPV> 8.5, PHA'yı doğru bir şekilde farklılaştırdı (AUC:% 70.2, duyarlılık:% 79.0, özgüllük:% 61.4).

Tartışma: Bu çalışmanın sonuçları; MPV taramasının komplikasyon veya fetal anomali olmayan gebeliklerde OHA ve PHA için prediktif bir değere sahip olduğunu göstermektedir.

Objectives: Amniotic fluid abnormalities are the leading cause of fetal morbidity and mortality. The aim of this study was to investigate whether prepartum mean platelet volume (MPV) is associated with and a predictable marker for oligohydramnios (OHA) and polyhydramnios (PHA).

Materials and Methods: In this retrospective study, an examination was made of the records of patients who were monitored and gave birth at Karabuk Training and Research Hospital Gynecology and Obstetrics Clinic in 2014-2015. Patients with isolated OHA and PHA were included in the study group and those with normal amnion fluid volume (AFV) in the control group.  A record was made of age, obstetric and clinical history, smoking, alcohol consumption, laboratory test results and ultrasonography reports in the third trimester of the pregnancy.

Results: A total of 284 pregnant women were included in the study. The MPV levels of the OHA and PHA groups were significantly higher than those of the normal group (p=0.000). There was no significant difference was observed between the OHA and PHA groups (p=0.20). MPV>8.4 accurately differentiated AFV (AUC:68.8%, sensitivity:78.6%, specificity:59.1%). MPV>8.0 accurately differentiated OHA (AUC:67.1%, sensitivity:84.4%, specificity:50.0%). MPV>8.5 accurately differentiated PHA (AUC:70.2%, sensitivity:79.0%, specificity:61.4%).

Conclusion: The result of the current study shows that screening MPV has a predictive value for OHA and PHA in pregnancies without complications or fetal anomaly.

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Birincil Dil en
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm Orjinal Araştırma
Yazarlar

Orcid: 0000-0002-7487-0047
Yazar: Neriman Çetin Benli
Kurum: Bağlar Aile Sağlığı Merkezi Safranbolu-Karabük
Ülke: Turkey


Orcid: 0000-0002-3149-5013
Yazar: Sibel Mutlu
Kurum: KARABUK UNIVERSITY
Ülke: Turkey


Orcid: 0000-0002-9596-4042
Yazar: Abdülkerim Yıldız (Sorumlu Yazar)
Kurum: UNIVERSITY OF HEALTH SCIENCES, ANKARA DIŞKAPI YILDIRIM BEYAZIT HEALTH RESEARCH CENTER, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE
Ülke: Turkey


Orcid: 0000-0003-0039-1497
Yazar: Ali Ramazan Benli
Kurum: KARABUK UNIVERSITY
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 30 Eylül 2019

EndNote %0 Journal of Contemporary Medicine Is higher mean platelet volume an additional predictive marker of oligohydramnios and polyhydramnios? %A Neriman Çetin Benli , Sibel Mutlu , Abdülkerim Yıldız , Ali Ramazan Benli %T Is higher mean platelet volume an additional predictive marker of oligohydramnios and polyhydramnios? %D 2019 %J Journal of Contemporary Medicine %P -2667-7180 %V 9 %N 3 %R doi: 10.16899/jcm.605491 %U 10.16899/jcm.605491