Research Article
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Year 2019, Volume: 9 Issue: 4, 359 - 364, 31.12.2019
https://doi.org/10.16899/jcm.605404

Abstract

References

  • 1) Gluckman E, Gratwohl A, Apperley J. The EBMT Handbook. In: J Apperley, E Carreras, E Gluckman, A Gratwohl, T Masszi, editors. Hematopoietic stem cell transplantation for primary amyloidosis in adult (5th ed), France 2008, pp. 424.
  • 2) EBMT criteria, form MED-A 2007.
  • 3) Allen RD, Staley TA, Sidman CL. Differential cytokine expression in acute and chronic murine graft- versus-host-disease. Eur J Immunol 1993; 23(2): 333-37.
  • 4) Ogawa M. Differentiation and Proliferation of Hematopoietic Stem Cells. Blood 1993; 81(11):2844-53.
  • 5) McDonald GB, Hinds MS, Fisher LD, et al. Venoocclusive disease of the liver and multiorgan failure after bone marrow transplantation a cohort study of 355 patients. Ann Intern Med 1993;118(4): 255–67.
  • 6) Kansoy S. TPHD 9. Ulusal Pediatrik Hematoloji Kongresi Van 24-28 mayıs 2013.
  • 7) Miano M, Labopin M, Hartman O, et al. Haematopoietic stem cell transplantation trends in children over the last three decades: a survey by the paediatric diseases woking party of the Europan Group for Blood and Marrow Transplantation. Bone Marrow Transplant 2007; 39: 89-99.
  • 8) Körbling M, Freireich EJ. Twenty five years of peripheral blood stem cell transplantation. Blood .2011; 117(24): 6411-6.9) Gluckman E, Broxmeyer HA, Auerbach AD, et al. Hematopoietic reconstitution in a patient with Fanconi’s anemia by means of umbilical cord-blood from HLH-identical sibling.N Eng J Med 1989; 321(17):1174-8.
  • 10) Kansoy S. Ulusal Pediatrik HKHT Aktivitesinin Değerlendirilmesi. Ege Üniversitesi Tıp Fakültesi, Pediyatrik KİT Ünitesi, TPHD KİT veritabanı, TPHD KİT Çalışma Grubu. 8. Ulusal Kemik İliği Transplantasyonu Ve Kök Hücre Tedavileri Kongresi 2014.
  • 11) Thissiane L Gonçalves, Dalila M Benvegnú, Gabriela Bonfanti. Specific factors influence the success of autologous and allogeneic hematopoietic stem cell transplantation. Oxid Med Cell Longev 2009; 2(2): 82-87.
  • 12) Beşışık S.K, Ülkemizde akraba dışı allogenik hematopoetik hücre nakli deneyimi. 4. Ulusal Kemik İliği Transplantasyonu ve Kök Hücre Tedavileri Kongresi Bildiri Özetleri, Bursa, 2007 s76.
  • 13) Engels E.A, Ellis C.A, Supran S.E, et al. Early Infection in Bone Marrow Transplantation: Quantitative Study of Clinical Factors That Affect Risk. Clinical Infectious Diseases 1999; 28 (2): 256- 266.
  • 14) Krüger W.H, Boblins J, Kornely O.A, et al. Antimicrobial prophylaxis in allogeneic bone marrow transplantation. Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Haematology and Oncology 2005; 16 (8): 1381-1390.
  • 15) Nobuhiro N, Hiroshi Y, Yoshiyuki T, Asahito H, Hideki M , Makito T, Nao Y, Ayami Y, Kazuko K, Masafumi I, Seiji K. Engraftment syndrome following allogeneic hematopoietic stem cell transplantation in children. Pediatric Transplantation. Pediatric Transplantation 2009; 13(7): 831-837.
  • 16) Stephen T. S, Gerry O, Hank F, Lisa B, Williamson Z.B, John E, Vanessa H, June E, Joel B.E, Francis G.L, Carole M,Douglas E.P, Mark M.S, Frederik K.L, Spijkervet, Mary H. Oral mucositis and the clinical ana economic outcomes of hematopoietic stem cell transplantation. Journal of Clinical Oncology 2001;19(8): 2201-2205.
  • 17) Ted A. Gooley, Ph.D., Jason W. Chien, M.D., Steven A. Pergam, M.D., M.P.H., Sangeeta Hingorani, M.D., M.P.H., Mohamed L. Sorror, M.D., Michael Boeckh, M.D., Paul J. Martin, M.D., Brenda M. Sandmaier, M.D., Kieren A. Marr, M.D., Frederick R. Appelbaum, M.D., Rainer Storb, M.D., and George B. McDonald, M.D. Reduced Mortality after Allogeneic Hematopoietic-Cell Transplantation. N Engl J Med 2010; 363: 2091-2101.
  • 18) Storb R, Pepe M, Deeg HJ, Anasetti C, Appelbaum FR, Bensinger W, Buckner CD, Clift RA, Doney K, Hansen J, Martin P, Pettinger M, Sanders JE, SingerJ, Stewart P, Sulhvan KM, Thomas ED, Witherspoon RP: Long-term follow-up of a controlled trial comparing a combination of methotrexate plus cyclosporine with cyelosporine alone for prophylaxis of graft-versus-host disease in patients administered HLA-identical marrow grafts for leukemia. Blood 1992; 80(2) :560.
  • 19) Sullivan KM, Agura E, Anasetti C, et al. Chronic graft-versus-host disease and other Iate compIicarions of bone marrow transplantation. Seminars in Hematology 1991; 28:250.
  • 20) Alicia R, Thomas D, Jörg H, Dominik H, Dimitrios A.T, Martin S, Tuomas W, Jan D.S, Alan T, Alois G, Andre T. Late altered organ function in very long-term survivors after allogeneic hematopoietic stem cell transplantation: a paired comparison with their HLA-identical sibling donor. Hematologica 2010; 96(1):150-155.
  • 21) Cantoni N, Hirsch HH, Khanna N, et al. Evidence for a Bidirectional Relationship between Cytomegalovirus Replication and acute Graft-versus-Host Disease. Biology of blood and marrow transplantation 2008;16(9): 1309-1314.
  • 22) Cesaro S, Pillon M, Talenti E, et al. A prospective survey on incidence, risk factors and therapy of hepatic veno-occlusive disease in children after hematopoietic stem cell transplantation. Haematologica 2005; 90: 1396–1404.
  • 23) Kuskonmaz B, Yalcin S, Kucukbayrak O, ark. The effect of glutamine supplementation on hematopoietic stem cell transplant outcome in children: a case-control study. Pediatr Transplant 2008;12 (1): 47-51.
  • 24) Koh K.N, Park M, Kim B.E, Im H.J, Seo J.J. Early central nervous system complications after allogeneic hematopoietic stem cell transplantation in children.The Korean Journal of Hematology 2010; 45: 164-70.
  • 25) Leung AY, Mark R, Yuen KY, Cheng VC, Liang V, Kwong YL. Clinicopathological features and risk factors of clinically overt haemorrhagic cystitis complicating bone marrow transplantation. Bone Marrow Transplant 2002; 29(6): 509-13.
  • 26) Seber A, Shu XO, Defor T, Sencer, Ramsay N. Risk Factors for Severe Hemorrhagic Cystitis Following BMT. Bone Marrow Transplant 1999; 23: 35-40.
  • 27) Yenerel M.N, Beşışık S.K, Perdeci O, Gürses N, Tunç M, Sargın D. Hyperbaric oxygen: an important treatment modality in severe hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation. Turk J Hematol 2009; 26: 176-80.

Retrospective Evaluation Of Children After Stem Cell Transplantation: Single Center Experience

Year 2019, Volume: 9 Issue: 4, 359 - 364, 31.12.2019
https://doi.org/10.16899/jcm.605404

Abstract

Abstract

Aim: Analysis of the data of children following stem cell transplantation.

Materials and Methods: A total of 44 children who received stem cell
transplant between February 2009 and May 2011 were evaluated retrospectively.

Results: Among the patients with a mean age of 9.6 ± 4.63 years, 20 (45.5%) were male, whereas 24 (54.5%) were
female. The initial diagnosis of the patients with decreasing order of
frequency was as follows: thalassemia major (n=15), acute leukemia (n=9),
Fanconi aplastic anemia (n=6), aplastic anemia (n=5) and other disorders (n=9).
Disease-free survival in two years was observed in 27 (61.3%) of patients.
Relapse occurred in 8 (18.1%) patients, whereas 9 (20.4%) patients died. The
mortality was transplant-related in two cases, whereas it was due to
progression of the underlying disease in 7 (15.9%) patients.







Conclusion: As the stem cell transplantation has become widespread
in Türkiye recently, its data are valuable. We found high incidence of
mucositis and infection due to myeloablative regimens. The limitation of our
study is the small number of patients included. 
Though, results obtained here are similar to those of national and
international studies. 






Supporting Institution

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Thanks

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References

  • 1) Gluckman E, Gratwohl A, Apperley J. The EBMT Handbook. In: J Apperley, E Carreras, E Gluckman, A Gratwohl, T Masszi, editors. Hematopoietic stem cell transplantation for primary amyloidosis in adult (5th ed), France 2008, pp. 424.
  • 2) EBMT criteria, form MED-A 2007.
  • 3) Allen RD, Staley TA, Sidman CL. Differential cytokine expression in acute and chronic murine graft- versus-host-disease. Eur J Immunol 1993; 23(2): 333-37.
  • 4) Ogawa M. Differentiation and Proliferation of Hematopoietic Stem Cells. Blood 1993; 81(11):2844-53.
  • 5) McDonald GB, Hinds MS, Fisher LD, et al. Venoocclusive disease of the liver and multiorgan failure after bone marrow transplantation a cohort study of 355 patients. Ann Intern Med 1993;118(4): 255–67.
  • 6) Kansoy S. TPHD 9. Ulusal Pediatrik Hematoloji Kongresi Van 24-28 mayıs 2013.
  • 7) Miano M, Labopin M, Hartman O, et al. Haematopoietic stem cell transplantation trends in children over the last three decades: a survey by the paediatric diseases woking party of the Europan Group for Blood and Marrow Transplantation. Bone Marrow Transplant 2007; 39: 89-99.
  • 8) Körbling M, Freireich EJ. Twenty five years of peripheral blood stem cell transplantation. Blood .2011; 117(24): 6411-6.9) Gluckman E, Broxmeyer HA, Auerbach AD, et al. Hematopoietic reconstitution in a patient with Fanconi’s anemia by means of umbilical cord-blood from HLH-identical sibling.N Eng J Med 1989; 321(17):1174-8.
  • 10) Kansoy S. Ulusal Pediatrik HKHT Aktivitesinin Değerlendirilmesi. Ege Üniversitesi Tıp Fakültesi, Pediyatrik KİT Ünitesi, TPHD KİT veritabanı, TPHD KİT Çalışma Grubu. 8. Ulusal Kemik İliği Transplantasyonu Ve Kök Hücre Tedavileri Kongresi 2014.
  • 11) Thissiane L Gonçalves, Dalila M Benvegnú, Gabriela Bonfanti. Specific factors influence the success of autologous and allogeneic hematopoietic stem cell transplantation. Oxid Med Cell Longev 2009; 2(2): 82-87.
  • 12) Beşışık S.K, Ülkemizde akraba dışı allogenik hematopoetik hücre nakli deneyimi. 4. Ulusal Kemik İliği Transplantasyonu ve Kök Hücre Tedavileri Kongresi Bildiri Özetleri, Bursa, 2007 s76.
  • 13) Engels E.A, Ellis C.A, Supran S.E, et al. Early Infection in Bone Marrow Transplantation: Quantitative Study of Clinical Factors That Affect Risk. Clinical Infectious Diseases 1999; 28 (2): 256- 266.
  • 14) Krüger W.H, Boblins J, Kornely O.A, et al. Antimicrobial prophylaxis in allogeneic bone marrow transplantation. Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Haematology and Oncology 2005; 16 (8): 1381-1390.
  • 15) Nobuhiro N, Hiroshi Y, Yoshiyuki T, Asahito H, Hideki M , Makito T, Nao Y, Ayami Y, Kazuko K, Masafumi I, Seiji K. Engraftment syndrome following allogeneic hematopoietic stem cell transplantation in children. Pediatric Transplantation. Pediatric Transplantation 2009; 13(7): 831-837.
  • 16) Stephen T. S, Gerry O, Hank F, Lisa B, Williamson Z.B, John E, Vanessa H, June E, Joel B.E, Francis G.L, Carole M,Douglas E.P, Mark M.S, Frederik K.L, Spijkervet, Mary H. Oral mucositis and the clinical ana economic outcomes of hematopoietic stem cell transplantation. Journal of Clinical Oncology 2001;19(8): 2201-2205.
  • 17) Ted A. Gooley, Ph.D., Jason W. Chien, M.D., Steven A. Pergam, M.D., M.P.H., Sangeeta Hingorani, M.D., M.P.H., Mohamed L. Sorror, M.D., Michael Boeckh, M.D., Paul J. Martin, M.D., Brenda M. Sandmaier, M.D., Kieren A. Marr, M.D., Frederick R. Appelbaum, M.D., Rainer Storb, M.D., and George B. McDonald, M.D. Reduced Mortality after Allogeneic Hematopoietic-Cell Transplantation. N Engl J Med 2010; 363: 2091-2101.
  • 18) Storb R, Pepe M, Deeg HJ, Anasetti C, Appelbaum FR, Bensinger W, Buckner CD, Clift RA, Doney K, Hansen J, Martin P, Pettinger M, Sanders JE, SingerJ, Stewart P, Sulhvan KM, Thomas ED, Witherspoon RP: Long-term follow-up of a controlled trial comparing a combination of methotrexate plus cyclosporine with cyelosporine alone for prophylaxis of graft-versus-host disease in patients administered HLA-identical marrow grafts for leukemia. Blood 1992; 80(2) :560.
  • 19) Sullivan KM, Agura E, Anasetti C, et al. Chronic graft-versus-host disease and other Iate compIicarions of bone marrow transplantation. Seminars in Hematology 1991; 28:250.
  • 20) Alicia R, Thomas D, Jörg H, Dominik H, Dimitrios A.T, Martin S, Tuomas W, Jan D.S, Alan T, Alois G, Andre T. Late altered organ function in very long-term survivors after allogeneic hematopoietic stem cell transplantation: a paired comparison with their HLA-identical sibling donor. Hematologica 2010; 96(1):150-155.
  • 21) Cantoni N, Hirsch HH, Khanna N, et al. Evidence for a Bidirectional Relationship between Cytomegalovirus Replication and acute Graft-versus-Host Disease. Biology of blood and marrow transplantation 2008;16(9): 1309-1314.
  • 22) Cesaro S, Pillon M, Talenti E, et al. A prospective survey on incidence, risk factors and therapy of hepatic veno-occlusive disease in children after hematopoietic stem cell transplantation. Haematologica 2005; 90: 1396–1404.
  • 23) Kuskonmaz B, Yalcin S, Kucukbayrak O, ark. The effect of glutamine supplementation on hematopoietic stem cell transplant outcome in children: a case-control study. Pediatr Transplant 2008;12 (1): 47-51.
  • 24) Koh K.N, Park M, Kim B.E, Im H.J, Seo J.J. Early central nervous system complications after allogeneic hematopoietic stem cell transplantation in children.The Korean Journal of Hematology 2010; 45: 164-70.
  • 25) Leung AY, Mark R, Yuen KY, Cheng VC, Liang V, Kwong YL. Clinicopathological features and risk factors of clinically overt haemorrhagic cystitis complicating bone marrow transplantation. Bone Marrow Transplant 2002; 29(6): 509-13.
  • 26) Seber A, Shu XO, Defor T, Sencer, Ramsay N. Risk Factors for Severe Hemorrhagic Cystitis Following BMT. Bone Marrow Transplant 1999; 23: 35-40.
  • 27) Yenerel M.N, Beşışık S.K, Perdeci O, Gürses N, Tunç M, Sargın D. Hyperbaric oxygen: an important treatment modality in severe hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation. Turk J Hematol 2009; 26: 176-80.
There are 26 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Research
Authors

Vildan Güngörer 0000-0002-9838-2603

Ebru Yılmaz Keskin 0000-0002-1462-9876

Tunç Fışgın 0000-0003-4467-9935

Publication Date December 31, 2019
Acceptance Date September 26, 2019
Published in Issue Year 2019 Volume: 9 Issue: 4

Cite

AMA Güngörer V, Yılmaz Keskin E, Fışgın T. Retrospective Evaluation Of Children After Stem Cell Transplantation: Single Center Experience. J Contemp Med. December 2019;9(4):359-364. doi:10.16899/jcm.605404