Yıl 2019, Cilt 9 , Sayı 4, Sayfalar 359 - 364 2019-12-31

Retrospective Evaluation Of Children After Stem Cell Transplantation: Single Center Experience

Vildan GÜNGÖRER [1] , Ebru YILMAZ KESKİN [2] , Tunç FIŞGIN [3]


Abstract

Aim: Analysis of the data of children following stem cell transplantation.

Materials and Methods: A total of 44 children who received stem cell transplant between February 2009 and May 2011 were evaluated retrospectively.

Results: Among the patients with a mean age of 9.6 ± 4.63 years, 20 (45.5%) were male, whereas 24 (54.5%) were female. The initial diagnosis of the patients with decreasing order of frequency was as follows: thalassemia major (n=15), acute leukemia (n=9), Fanconi aplastic anemia (n=6), aplastic anemia (n=5) and other disorders (n=9). Disease-free survival in two years was observed in 27 (61.3%) of patients. Relapse occurred in 8 (18.1%) patients, whereas 9 (20.4%) patients died. The mortality was transplant-related in two cases, whereas it was due to progression of the underlying disease in 7 (15.9%) patients.

Conclusion: As the stem cell transplantation has become widespread in Türkiye recently, its data are valuable. We found high incidence of mucositis and infection due to myeloablative regimens. The limitation of our study is the small number of patients included.  Though, results obtained here are similar to those of national and international studies. 






Hematopoietic stem cell transplantation, prognosis, transplant-related mortality
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Orcid: 0000-0002-9838-2603
Yazar: Vildan GÜNGÖRER (Sorumlu Yazar)
Kurum: ONDOKUZ MAYIS ÜNİVERSİTESİ, TIP FAKÜLTESİ
Ülke: Turkey


Orcid: 0000-0002-1462-9876
Yazar: Ebru YILMAZ KESKİN
Kurum: SAMSUN EĞİTİM VE ARAŞTIRMA HASTANESİ
Ülke: Turkey


Orcid: 0000-0003-4467-9935
Yazar: Tunç FIŞGIN
Kurum: ONDOKUZ MAYIS ÜNİVERSİTESİ, TIP FAKÜLTESİ
Ülke: Turkey


Destekleyen Kurum None
Teşekkür None
Tarihler

Yayımlanma Tarihi : 31 Aralık 2019

EndNote %0 Journal of Contemporary Medicine Retrospective Evaluation Of Children After Stem Cell Transplantation: Single Center Experience %A Vildan GÜNGÖRER , Ebru YILMAZ KESKİN , Tunç FIŞGIN %T Retrospective Evaluation Of Children After Stem Cell Transplantation: Single Center Experience %D 2019 %J Journal of Contemporary Medicine %P -2667-7180 %V 9 %N 4 %R doi: 10.16899/jcm.605404 %U 10.16899/jcm.605404