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Year 2018, , 779 - 779, 18.08.2018
https://doi.org/10.37212/jcnos.610084

Abstract

References

  • Braidy N, Berg J, Clement J, Khorshidi F, Poljak A, Jayasena T, Grant R, Sachdev P. 2018. NAD+ Precursors as Therapeutic Agents for Age-related Degenerative Diseases. Antioxidant and Redox Signaling. http://doi.org/10.1089/ars.2017.7269
  • Braidy N, Grant R, Sachdev P. 2017. Nicotinamide adenine dinucleotide and its related precursors for the treatment of Alzheimer’s disease. Current Opinion in Psychiatry. http://doi.org/10.1097/YCO.0000000000000394.

Intravenous NAD+ effectively increased the NAD metabolome, reduced oxidative stress and inflammation, and increased expression of longevity genes safely in elderly humans

Year 2018, , 779 - 779, 18.08.2018
https://doi.org/10.37212/jcnos.610084

Abstract

Nicotinamide adenine dinucleotide (NAD+) serves important roles in hydrogen transfer and as the cosubstrate for poly(ADP-ribose) polymerase (PARPs), the sirtuin (SIRT1-7) family of enzymes, and CD38 glycohydrolases. Recently, intravenous (IV) NAD+ therapy has been used as a holistic approach to treat withdrawal from addiction, overcome anxiety and depression, and improve overall quality of life with minimal symptoms between 3-7 days of treatment. We evaluated repeat dose IV NAD+ (1000 mg) for 6 days in a population of 8 healthy adults between the ages of 70 and 80 years. Our data is the first to show that IV NAD+ increases the blood NAD+ metabolome in elderly humans. We found increased concentrations of glutathione peroxidase -3 and paraoxonase-1, anddecreased concentrations of 8-iso-prostaglandin F2α, advanced oxidative protein products, protein carbonyl, C-reactive protein and interleukin 6. We report significant increases in mRNA expression and activity of SIRT1, and Forkhead box O1, and reduced acetylated p53 in peripheral blood mononuclear cells isolated from these subjects. No major adverse effects were reported in this study. The study shows that repeat IV dose of NAD+ is a safe and efficient way to slow down age-related decline in NAD+.

References

  • Braidy N, Berg J, Clement J, Khorshidi F, Poljak A, Jayasena T, Grant R, Sachdev P. 2018. NAD+ Precursors as Therapeutic Agents for Age-related Degenerative Diseases. Antioxidant and Redox Signaling. http://doi.org/10.1089/ars.2017.7269
  • Braidy N, Grant R, Sachdev P. 2017. Nicotinamide adenine dinucleotide and its related precursors for the treatment of Alzheimer’s disease. Current Opinion in Psychiatry. http://doi.org/10.1097/YCO.0000000000000394.
There are 2 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Original Articles
Authors

Nady Braıdy

Publication Date August 18, 2018
Published in Issue Year 2018

Cite

APA Braıdy, N. (2018). Intravenous NAD+ effectively increased the NAD metabolome, reduced oxidative stress and inflammation, and increased expression of longevity genes safely in elderly humans. Journal of Cellular Neuroscience and Oxidative Stress, 10(3), 779-779. https://doi.org/10.37212/jcnos.610084
AMA Braıdy N. Intravenous NAD+ effectively increased the NAD metabolome, reduced oxidative stress and inflammation, and increased expression of longevity genes safely in elderly humans. J Cell Neurosci Oxid Stress. August 2018;10(3):779-779. doi:10.37212/jcnos.610084
Chicago Braıdy, Nady. “Intravenous NAD+ Effectively Increased the NAD Metabolome, Reduced Oxidative Stress and Inflammation, and Increased Expression of Longevity Genes Safely in Elderly Humans”. Journal of Cellular Neuroscience and Oxidative Stress 10, no. 3 (August 2018): 779-79. https://doi.org/10.37212/jcnos.610084.
EndNote Braıdy N (August 1, 2018) Intravenous NAD+ effectively increased the NAD metabolome, reduced oxidative stress and inflammation, and increased expression of longevity genes safely in elderly humans. Journal of Cellular Neuroscience and Oxidative Stress 10 3 779–779.
IEEE N. Braıdy, “Intravenous NAD+ effectively increased the NAD metabolome, reduced oxidative stress and inflammation, and increased expression of longevity genes safely in elderly humans”, J Cell Neurosci Oxid Stress, vol. 10, no. 3, pp. 779–779, 2018, doi: 10.37212/jcnos.610084.
ISNAD Braıdy, Nady. “Intravenous NAD+ Effectively Increased the NAD Metabolome, Reduced Oxidative Stress and Inflammation, and Increased Expression of Longevity Genes Safely in Elderly Humans”. Journal of Cellular Neuroscience and Oxidative Stress 10/3 (August 2018), 779-779. https://doi.org/10.37212/jcnos.610084.
JAMA Braıdy N. Intravenous NAD+ effectively increased the NAD metabolome, reduced oxidative stress and inflammation, and increased expression of longevity genes safely in elderly humans. J Cell Neurosci Oxid Stress. 2018;10:779–779.
MLA Braıdy, Nady. “Intravenous NAD+ Effectively Increased the NAD Metabolome, Reduced Oxidative Stress and Inflammation, and Increased Expression of Longevity Genes Safely in Elderly Humans”. Journal of Cellular Neuroscience and Oxidative Stress, vol. 10, no. 3, 2018, pp. 779-, doi:10.37212/jcnos.610084.
Vancouver Braıdy N. Intravenous NAD+ effectively increased the NAD metabolome, reduced oxidative stress and inflammation, and increased expression of longevity genes safely in elderly humans. J Cell Neurosci Oxid Stress. 2018;10(3):779-.