HEPATOPROTECTIVE EFFECT OF TOFU PROCESSED FROM GERMINATED SOYBEAN ON CARBON TETRACHLORIDE INDUCED CHRONIC LIVER INJURY IN MICE

Abstract

The hepatoprotective activities of silk tofu made from germinated and non germinated soybeans at different doses of feeding against CCl₄ induced hepatic cell toxicity in mice was investigated in this study. The heptatoprotective activity was analyzed by assessing the ratio of liver weight to body weight (L/B), the levels of serum alanine aminotransferase (ALT), total cholesterols (TC), the hepatic malondehydyde (MDA), protein carbonyl (PC) and vitamin C levels as well as the histopathological analysis of liver tissue. All types of silk tofu significantly reduced the L/B value; ALT activity, total cholesterol, hepatic MDA and PC levels, beside, liver vitamin C content increased compared to CCl₄ intoxicated mice. Silk tofu made from germinated soybeans expressed higher hepatoprotective activity as compared to silk tofu made from non germinated soybeans. Mice fed with silk tofu made from germinated soybeans at the dose of 0.4 g/g body weight/day displayed all biochemical parameters as well as the liver tissue histopathological analysis that were similar to that of normal mice and silymarin treated mice. It was suggested that tofu specially made from germinated soybeans expressed great hepatoprotective effect.

Keywords

• Liver injury,Carbon tetrachloride,Silk to-fu,Germination,Antioxidants

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