Research Article
Year 2020,
, 345 - 348, 25.06.2020
Abstract
Amaç: Bu çalışmada uterusa sınırlı endometroid endometrium kanserinde, tümör lokalizasyonunun prognoza etkisinin araştırılması hedeflenmiştir.
Gereçler ve Yöntem: Retrospektif olarak dosya kayıtları incelendi. Tümörün yerleşim yeri (fundus, korpus, istmus veya yaygın) ve şekli açık olarak patoloji raporlarında belirtilen hastalar tespit edildi. Bu hastalardan evre I-II olan, endometroid histoloji ve tam takip bilgilerine sahip olan hastalar çalışmaya dahil edildi. Tümörün yerleşim yerine göre yaşam analizleri karşılaştırıldı.
Bulgular: Çalışma, uterusa sınırlı endometroid endometrial kanseri olan 99 hastayla yürütüldü. Lokalizasyon dağılımları; fundus 37 (%37,4), korpus 24 (%24,2), istmus 6 (%6,1) ve yaygın 32 (%32,3) şeklinde tespit edildi. Univaryant analizde, diğer yerleşim yerlerine göre (fundus: %100, korpus: %94, yaygın: %94) istmik yerleşimli tümörler (%64), istatistiksel olarak anlamlı daha az 5-yıllık hastalıksız sağkalıma sahip idi (p=0.033). Ancak bu anlamlılık multivaryant analizle teyit edilmedi (HR: 0.037, GA: 0.000-2.345). Kanser spesifik sağkalım bakımından ise, tümörün yerleşim yerine göre hastalar arasında anlamlı fark yoktu.
Sonuç: Uterusa sınırlı endometroid endometrial kanserlerde, tümörün yerleşim yeri ne hastalıksız ne de kanser spesifik sağkalım için bağımsız prognostik faktördü.
Keywords
References
- 1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018 Nov;68(6):394-424. 2. Gultekin M, Kucukyildiz I, Karaca MZ, Dundar S, Boztas G, Turan SH, et al. Trends of Gynecological Cancers in Turkey: Toward Europe or Asia? Int J Gynecol Cancer 2017 Oct;27(8S):S1-S9. 3. Bokhman JV. Two pathogenetic types of endometrial carcinoma. Gynecol Oncol 1983 Feb;15(1):10-7. 4. Arem H, Irwin ML. Obesity and endometrial cancer survival: a systematic review. Int J Obes (Lond) 2013 May;37(5):634-9. 5. Bouwman F, Smits A, Lopes A, Das N, Pollard A, Massuger L, et al. The impact of BMI on surgical complications and outcomes in endometrial cancer surgery--an institutional study and systematic review of the literature. Gynecol Oncol 2015 Nov;139(2):369-76. 6. Doll KM, Tseng J, Denslow SA, Fader AN, Gehrig PA. High-grade endometrial cancer: revisiting the impact of tumor size and location on outcomes. Gynecol Oncol 2014 Jan;132(1):44-9. 7. Kizer NT, Gao F, Guntupalli S, Thaker PH, Powell MA, Goodfellow PJ, et al. Lower uterine segment involvement is associated with poor outcomes in early-stage endometrioid endometrial carcinoma. Ann Surg Oncol 2011 May;18(5):1419-24. 8. Brown AK, Madom L, Moore R, Granai CO, DiSilvestro P. The prognostic significance of lower uterine segment involvement in surgically staged endometrial cancer patients with negative nodes. Gynecol Oncol 2007 Apr;105(1):55-8. 9. Creasman WT, Morrow CP, Bundy BN, Homesley HD, Graham JE, Heller PB. Surgical pathologic spread patterns of endometrial cancer. A Gynecologic Oncology Group Study. Cancer 1987 Oct 15;60(8 Suppl):2035-41. 10. Erkaya S, Oz M, Topcu HO, Sirvan AL, Gungor T, Meydanli MM. Is lower uterine segment involvement a prognostic factor in endometrial cancer? Turk J Med Sci 2017 Feb 27;47(1):300-6. 11. Dilek S, Dede M, Gezginc K, Yenen MC, Goktolga U, Ulutin HC, et al. Does the localisation of tumour at stage I endometrial endometrioid adenocarcinoma have an impact on invasion of the tumour and individualisation of the surgical procedure? Eur J Gynaecol Oncol 2008;29(2):138-40. 12. Hachisuga T, Kaku T, Enjoji M. Carcinoma of the lower uterine segment. Clinicopathologic analysis of 12 cases. Int J Gynecol Pathol 1989;8(1):26-35. 13. Phelan C, Montag AG, Rotmensch J, Waggoner SE, Yamada SD, Mundt AJ. Outcome and management of pathological stage I endometrial carcinoma patients with involvement of the lower uterine segment. Gynecol Oncol 2001 Dec;83(3):513-7. 14. Gemer O, Uriev L, Harkovsky T, Peled R, Ben-Dor D, Barak F, et al. Significance of lower uterine segment involvement in women with stage I endometrial adenocarcinoma. J Reprod Med 2004 Sep;49(9):703-6. 15. Mayr NA, Wen BC, Benda JA, Sorosky JI, Davis CS, Fuller RW, et al. Postoperative radiation therapy in clinical stage I endometrial cancer: corpus, cervical, and lower uterine segment involvement--patterns of failure. Radiology 1995 Aug;196(2):323-8. 16. Gemer O, Gdalevich M, Voldarsky M, Barak F, Ben Arie A, Schneider D, et al. Lower uterine segment involvement is associated with adverse outcome in patients with stage I endometroid endometrial cancer: results of a multicenter study. Eur J Surg Oncol 2009 Aug;35(8):865-9. 17. Kogan L, Octeau D, Amajoud Z, Abitbol J, Laskov I, Ferenczy A, et al. Impact of lower uterine segment involvement in type II endometrial cancer and the unique mutational profile of serous tumors. Gynecol Oncol Rep 2018 May;24:43-7. 18. Westin SN, Lacour RA, Urbauer DL, Luthra R, Bodurka DC, Lu KH, et al. Carcinoma of the lower uterine segment: a newly described association with Lynch syndrome. J Clin Oncol 2008 Dec 20;26(36):5965-71.
Year 2020,
, 345 - 348, 25.06.2020
Abstract
References
- 1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018 Nov;68(6):394-424. 2. Gultekin M, Kucukyildiz I, Karaca MZ, Dundar S, Boztas G, Turan SH, et al. Trends of Gynecological Cancers in Turkey: Toward Europe or Asia? Int J Gynecol Cancer 2017 Oct;27(8S):S1-S9. 3. Bokhman JV. Two pathogenetic types of endometrial carcinoma. Gynecol Oncol 1983 Feb;15(1):10-7. 4. Arem H, Irwin ML. Obesity and endometrial cancer survival: a systematic review. Int J Obes (Lond) 2013 May;37(5):634-9. 5. Bouwman F, Smits A, Lopes A, Das N, Pollard A, Massuger L, et al. The impact of BMI on surgical complications and outcomes in endometrial cancer surgery--an institutional study and systematic review of the literature. Gynecol Oncol 2015 Nov;139(2):369-76. 6. Doll KM, Tseng J, Denslow SA, Fader AN, Gehrig PA. High-grade endometrial cancer: revisiting the impact of tumor size and location on outcomes. Gynecol Oncol 2014 Jan;132(1):44-9. 7. Kizer NT, Gao F, Guntupalli S, Thaker PH, Powell MA, Goodfellow PJ, et al. Lower uterine segment involvement is associated with poor outcomes in early-stage endometrioid endometrial carcinoma. Ann Surg Oncol 2011 May;18(5):1419-24. 8. Brown AK, Madom L, Moore R, Granai CO, DiSilvestro P. The prognostic significance of lower uterine segment involvement in surgically staged endometrial cancer patients with negative nodes. Gynecol Oncol 2007 Apr;105(1):55-8. 9. Creasman WT, Morrow CP, Bundy BN, Homesley HD, Graham JE, Heller PB. Surgical pathologic spread patterns of endometrial cancer. A Gynecologic Oncology Group Study. Cancer 1987 Oct 15;60(8 Suppl):2035-41. 10. Erkaya S, Oz M, Topcu HO, Sirvan AL, Gungor T, Meydanli MM. Is lower uterine segment involvement a prognostic factor in endometrial cancer? Turk J Med Sci 2017 Feb 27;47(1):300-6. 11. Dilek S, Dede M, Gezginc K, Yenen MC, Goktolga U, Ulutin HC, et al. Does the localisation of tumour at stage I endometrial endometrioid adenocarcinoma have an impact on invasion of the tumour and individualisation of the surgical procedure? Eur J Gynaecol Oncol 2008;29(2):138-40. 12. Hachisuga T, Kaku T, Enjoji M. Carcinoma of the lower uterine segment. Clinicopathologic analysis of 12 cases. Int J Gynecol Pathol 1989;8(1):26-35. 13. Phelan C, Montag AG, Rotmensch J, Waggoner SE, Yamada SD, Mundt AJ. Outcome and management of pathological stage I endometrial carcinoma patients with involvement of the lower uterine segment. Gynecol Oncol 2001 Dec;83(3):513-7. 14. Gemer O, Uriev L, Harkovsky T, Peled R, Ben-Dor D, Barak F, et al. Significance of lower uterine segment involvement in women with stage I endometrial adenocarcinoma. J Reprod Med 2004 Sep;49(9):703-6. 15. Mayr NA, Wen BC, Benda JA, Sorosky JI, Davis CS, Fuller RW, et al. Postoperative radiation therapy in clinical stage I endometrial cancer: corpus, cervical, and lower uterine segment involvement--patterns of failure. Radiology 1995 Aug;196(2):323-8. 16. Gemer O, Gdalevich M, Voldarsky M, Barak F, Ben Arie A, Schneider D, et al. Lower uterine segment involvement is associated with adverse outcome in patients with stage I endometroid endometrial cancer: results of a multicenter study. Eur J Surg Oncol 2009 Aug;35(8):865-9. 17. Kogan L, Octeau D, Amajoud Z, Abitbol J, Laskov I, Ferenczy A, et al. Impact of lower uterine segment involvement in type II endometrial cancer and the unique mutational profile of serous tumors. Gynecol Oncol Rep 2018 May;24:43-7. 18. Westin SN, Lacour RA, Urbauer DL, Luthra R, Bodurka DC, Lu KH, et al. Carcinoma of the lower uterine segment: a newly described association with Lynch syndrome. J Clin Oncol 2008 Dec 20;26(36):5965-71.
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Details
| Primary Language | Turkish |
|---|---|
| Subjects | Obstetrics and Gynaecology |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | June 25, 2020 |
| Submission Date | December 23, 2019 |
| Acceptance Date | June 26, 2020 |
| Published in Issue | Year 2020 |