A CUT OFF VALUE FOR ADVANCED MATERNAL AGE IN PREDICTING ADVERSE OBSTETRIC AND NEONATAL OUTCOMES IN SPONTANEOUS PREGNANCIES

Canan Unal; Atakan Tanacan; Erdem Fadıloğlu; Nurhayat Halis; Murat Cagan; M.sinan Beksac

doi:10.38136/jgon.724384

A CUT OFF VALUE FOR ADVANCED MATERNAL AGE IN PREDICTING ADVERSE OBSTETRIC AND NEONATAL OUTCOMES IN SPONTANEOUS PREGNANCIES

Abstract

Amaç: 40 yaşın üzerindeki spontan gebeliklerde olumsuz obstetrik ve neonatal sonuçları tahmin etmek için anne yaşı için bir eşik değer tanımlamak. Yöntem: 40 yaş ve üzeri 359 gebelik retrospektif olarak değerlendirildi. Gebeler grup 1 (40-43) ve grup 2 (≥44) olmak üzere iki gruba ayrıldı. Çalışma gruplarının obstetrik ve neonatal sonuçları karşılaştırıldı. Ayrıca maternal yaş açısından olumsuz obstetrik ve neonatal sonuçları tahmin etmek için ROC eğrisi analizi yapıldı. Bulgular: Obstetrik komplikasyon oranı grup 2'de (% 80.5) grup 1'den (% 36.5) anlamlı olarak daha yüksekti (p <0.001). Preeklampsi oranı da grup 2'de anlamlı olarak daha fazlaydı (p: 0.001). NICU'ya yatış oranları, grup 2'de (% 77.1) grup 1'e (% 28.7) göre istatistiksel olarak anlamlı derecede yüksekti (p <0.001). ROC eğrisi analizi, 41.5 yaşın olumsuz yenidoğan sonuçlarını ve NICU’ya ihtiyacı tahmin etmek için bir eşik değeri olarak bulundu (AUC: 0.607,0.566 sırasıyla). Sonuç: Doktorlar ileri anne yaşı gebeliklerinin yönetiminde özellikle ≥41,5 yaş grubunda olan annelerde daha dikkatli olmalıdırlar. Background: To define a cut off value for maternal age to predict adverse obstetric and neonatal outcomes in spontaneous pregnancies ≥40 years of age. Methods: We retrospectively evaluated 359 pregnant women ≥40 years of age. Patients were enrolled into two groups as Group 1 (40-43) and Group 2 (≥44). We compared the obstetric and neonatal adverse outcomes of the study groups. We also performed ROC curve analysis to predict adverse obstetric and neonatal outcomes in terms of maternal age. Results: Composite obstetric complication rate was significantly higher in group 2 (80.5%) than in group 1 (36.5%) (p < 0.001). Preeclampsia rate was also significantly more common in group 2 (p: 0.001). Admission to NICU was statistically significantly higher in group 2 (77.1%) compared to group 1 (28.7%) (p < 0.001). ROC curve analysis revealed 41.5 years of age as a cut-off value for predicting adverse neonatal outcomes and NICU admission (AUC: 0.607 and 0.566, respectively). Conclusion: Physicians should be cautious in the management of advence maternal age (AMA) pregnancies especially in patients with maternal age of ≥41.5 years.

Keywords

Advanced maternal age,, adverse obstetric outcome,, adverse neonatal outcome,, high risk pregnancy,, pregnancy

References

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Details

Primary Language

English

Subjects

Obstetrics and Gynaecology

Journal Section

Research Article

Authors

Canan Unal ^*
0000-0003-0881-2831
Türkiye

Atakan Tanacan
0000-0001-8209-8248
Türkiye

Erdem Fadıloğlu This is me
0000-0001-7953-2517
Türkiye

Nurhayat Halis This is me
0000-0003-0014-121X
Türkiye

Murat Cagan This is me
0000-0003-0629-4401
Türkiye

M.sinan Beksac
0000-0001-6362-787X
Türkiye

Publication Date

September 30, 2020

Submission Date

April 21, 2020

Acceptance Date

May 16, 2020

Published in Issue

Year 2020 Volume: 17 Number: 3

DOI

https://doi.org/10.38136/jgon.724384

IZ

https://izlik.org/JA44TS59NG

Cite

RIS / Bibtex

APA

Unal, C., Tanacan, A., Fadıloğlu, E., Halis, N., Cagan, M., & Beksac, M. (2020). A CUT OFF VALUE FOR ADVANCED MATERNAL AGE IN PREDICTING ADVERSE OBSTETRIC AND NEONATAL OUTCOMES IN SPONTANEOUS PREGNANCIES. Jinekoloji-Obstetrik Ve Neonatoloji Tıp Dergisi, 17(3), 446-449. https://doi.org/10.38136/jgon.724384

AMA

1.Unal C, Tanacan A, Fadıloğlu E, Halis N, Cagan M, Beksac M. A CUT OFF VALUE FOR ADVANCED MATERNAL AGE IN PREDICTING ADVERSE OBSTETRIC AND NEONATAL OUTCOMES IN SPONTANEOUS PREGNANCIES. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi. 2020;17(3):446-449. doi:10.38136/jgon.724384

Chicago

Unal, Canan, Atakan Tanacan, Erdem Fadıloğlu, Nurhayat Halis, Murat Cagan, and M.sinan Beksac. 2020. “A CUT OFF VALUE FOR ADVANCED MATERNAL AGE IN PREDICTING ADVERSE OBSTETRIC AND NEONATAL OUTCOMES IN SPONTANEOUS PREGNANCIES”. Jinekoloji-Obstetrik Ve Neonatoloji Tıp Dergisi 17 (3): 446-49. https://doi.org/10.38136/jgon.724384.

EndNote

Unal C, Tanacan A, Fadıloğlu E, Halis N, Cagan M, Beksac M (September 1, 2020) A CUT OFF VALUE FOR ADVANCED MATERNAL AGE IN PREDICTING ADVERSE OBSTETRIC AND NEONATAL OUTCOMES IN SPONTANEOUS PREGNANCIES. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi 17 3 446–449.

IEEE

[1]C. Unal, A. Tanacan, E. Fadıloğlu, N. Halis, M. Cagan, and M. Beksac, “A CUT OFF VALUE FOR ADVANCED MATERNAL AGE IN PREDICTING ADVERSE OBSTETRIC AND NEONATAL OUTCOMES IN SPONTANEOUS PREGNANCIES”, Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi, vol. 17, no. 3, pp. 446–449, Sept. 2020, doi: 10.38136/jgon.724384.

ISNAD

Unal, Canan - Tanacan, Atakan - Fadıloğlu, Erdem - Halis, Nurhayat - Cagan, Murat - Beksac, M.sinan. “A CUT OFF VALUE FOR ADVANCED MATERNAL AGE IN PREDICTING ADVERSE OBSTETRIC AND NEONATAL OUTCOMES IN SPONTANEOUS PREGNANCIES”. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi 17/3 (September 1, 2020): 446-449. https://doi.org/10.38136/jgon.724384.

JAMA

1.Unal C, Tanacan A, Fadıloğlu E, Halis N, Cagan M, Beksac M. A CUT OFF VALUE FOR ADVANCED MATERNAL AGE IN PREDICTING ADVERSE OBSTETRIC AND NEONATAL OUTCOMES IN SPONTANEOUS PREGNANCIES. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi. 2020;17:446–449.

MLA

Unal, Canan, et al. “A CUT OFF VALUE FOR ADVANCED MATERNAL AGE IN PREDICTING ADVERSE OBSTETRIC AND NEONATAL OUTCOMES IN SPONTANEOUS PREGNANCIES”. Jinekoloji-Obstetrik Ve Neonatoloji Tıp Dergisi, vol. 17, no. 3, Sept. 2020, pp. 446-9, doi:10.38136/jgon.724384.

Vancouver

1.Canan Unal, Atakan Tanacan, Erdem Fadıloğlu, Nurhayat Halis, Murat Cagan, M.sinan Beksac. A CUT OFF VALUE FOR ADVANCED MATERNAL AGE IN PREDICTING ADVERSE OBSTETRIC AND NEONATAL OUTCOMES IN SPONTANEOUS PREGNANCIES. Jinekoloji-Obstetrik ve Neonatoloji Tıp Dergisi. 2020 Sep. 1;17(3):446-9. doi:10.38136/jgon.724384