Yüksek FSH değeri her zaman kötü prognostik faktör müdür?

Abstract

Azalmış over rezervi, in vitro fertilizasyon (IVF) tedavisi endikasyonlarından biridir. Bazal FSH seviyelerinin yüksek olması, düşük AMH düzeyi ve antral folikül sayısında azalma tüp bebek başarısını etkileyen olumsuz prognostik faktörler olarak değerlendirilmektedir. Biz bu çalışmada; 33 yaşında FSH değeri 42 IU/L olan ve düşük AMH değerine sahip, azalmış over rezervi nedeniyle IVF tedavisi uygulanan ve ilk siklusta gebe kalan ve gebeliği devam eden olguyu sunmayı amaçladık.

Keywords

• Yüksek FSH
• IVF başarısı
• düşük AMH
• azalmış over rezervi

High FSH value always a bad prognostic factor?

Abstract

Decreased ovarian reserve is one of the indications for in vitro fertilization (IVF) treatment. High basal FSH levels, low AMH level and decrease in the number of antral follicles are considered as negative prognostic factors affecting IVF success. In this study; We aimed to present a 33-year-old case with a former FSH value of 42 IU/L and low AMH values, who underwent IVF treatment due to decreased ovarian reserve, who is pregnant in the first cycle and whose pregnancy continued.

Keywords

• Elevated FSH
• IVF success
• low AMH
• diminished ovarian reserve

References

1. 1. Practice Committee of the American Society for Reproductive Medicine. Testing and interpreting measures of ovarian reserve: A committee opinion. Fertil Steril. 2012;98:1407–15.
2. 2. Chang Y, Li J, Li X, Liu H, Liang X. Egg Quality and Pregnancy Outcome in Young Infertile Women with Diminished Ovarian Reserve. Med Sci Monit. 2018 Oct 12;24:7279-7284.
3. 3.Lu Q, Shen H, Li Y, Zhang C, Wang C, Chen X, et al. Low testosterone levels in women with diminished ovarian reserve impair embryo implantation rate: a retrospective case-control study. J Assist Reprod Genet. 2014;31(4):485–91.
4. 4.Yilmaz N, Uygur D, Inal H, Gorkem U, Cicek N, Mollamahmutoglu L. Dehydroepiandrosterone supplementation improves predictive markers for diminished ovarian reserve: serum AMH, inhibin B and antral follicle count. Eur J Obstet Gynecol Reprod Biol. 2013;169(2):257–60.
5. 5.Check JH, Summers-Chase D, Yuan W, Horwath D, Wilson C. Effect of embryo quality on pregnancy outcome following single embryo transfer in women with a diminished egg reserve. Fertil Steril. 2007;87(4):749–56
6. 6.Tanbo T, Dale PO, Abyholm T, Stokke KT: Follicle-stimulating hormone as a prognostic indicator in clomiphene citrate/human menopausal gonadotropin-stimulated cycles for in vitro fertilization. Hum Reprod 1989; 4:647
7. 7. Scott RT, Toner JP, Muasher SJ, Oehninger S, Robinson S, Rosenwaks Z: Follicle-stimulating hormone levels on cycle day 3 are predictive of in vitro fertilization outcome. Fertil Steril 1989; 51:651
8. 8. Toner JP, Philput CB, Jones GS, Muasher SJ. Basal follicle-stimulating hormone level is a better predictor of in vitro fertilization performance than age. Fertil Steril. 1991 ;55(4):784-91.

9. 9. Martin, J. S. B., Nisker, J. A., Tummon, I. S., Daniel, S. A. J., Auckland, J. L., & Feyles, V. (1996). Future in vitro fertilization pregnancy potential of women with variably elevated day 3 follicle-stimulating hormone levels. Fertility and Sterility, 65(6), 1238–1240.
10. 10.Roberts, J., Spandorfer, S., Fasoulıotıs, S., Kashyap, S., & Rosenwaks, Z. (2005). Taking a basal follicle-stimulating hormone history is essential before initiating in vitro fertilization. Fertility and Sterility, 83(1), 37–41.