UTERUS TRANSPLANTASYONUNDA CANLI VE ÖLÜ DONÖR SEÇİMİ

Year 2021, Volume: 18 Issue: 2, 840 - 846, 01.07.2021

Nurcan Kırca Meryem Öngen

https://doi.org/10.38136/jgon.725241

Abstract

Doğurganlık çağındaki her 500 kadından birinde uterin faktör infertilitesi bulunmaktadır. Uterin faktör infertilitesine neden olan durumlar arasında; endometrial ve servikal kanser nedeniyle histerektomi, müllerian kanal agenezisi nedeniyle uterus ve vajina gelişiminin olmaması, uterus unikornus, bikornus ve uterin septum nedeniyle implantasyon başarısızlığı ve abortus, şiddetli uterin adhezyonlar yer almaktadır. Uterus transplantasyonu, uterin faktörü infertilitesi olan kadınların gebe kalabilmelerine ve bebeklerini taşıyabilmelerine imkân sunmaktadır. Ayrıca, transplante edilen uterusun alıcıda geçici bir süreliğine kalması nedeniyle uzun dönemde görülebilecek immünolojik ret reaksiyonu riski de önemli ölçüde azalmaktadır. Şu ana kadar canlı donörden nakledilen uterusla dokuz canlı doğum, ölü donörden nakledilen uterusla da bir canlı doğum bildirilmiştir. Transplantasyon için hem canlı hem de ölü donör kullanımına yönelik başarılı örneklerin olması bu yöntemin gelişimi için umut vericidir.

Keywords

Canlı donör, ölü donör, uterus transplantasyonu

References

• 1. Milliez J. Uterine transplantation FIGO Committee for the Ethical Aspects of Human Reproduction and Women's Health. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 2009; 106(3):270.
• 2. Oppelt P, Renner SP, Kellermann A, Brucker S, Hauser GA, Ludwig KS, et al. Clinical aspects of Mayer-Rokitansky-Kuester-Hauser syndrome: recommendations for clinical diagnosis and staging. Human reproduction (Oxford, England) 2006; 21(3):792-7.
• 3. Brannstrom M. Current status and future direction of uterus transplantation. Current opinion in organ transplantation 2018; 23(5):592-7.
• 4. Testa G, McKenna GJ, Gunby RT, Anthony T, Koon EC, Warren AM, et al. First live birth after uterus transplantation in the United States. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2018;18(5): 1270-4.
• 5. Brannstrom M, Johannesson L, Bokstrom H, Kvarnstrom N, Molne J, Dahm-Kahler P, et al. Livebirth after uterus transplantation. Lancet (London, England) 2015; 385(9968):607-16.
• 6. Fageeh W, Raffa H, Jabbad H, Marzouki A. Transplantation of the human uterus. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 2002; 76(3):245-51.
• 7. Ozkan O, Akar ME, Ozkan O, Erdogan O, Hadimioglu N, Yilmaz M, et al. Preliminary results of the first human uterus transplantation from a multiorgan donor. Fertility and sterility 2013; 99(2):470-6.
• 8. Erman Akar M, Ozkan O, Aydinuraz B, Dirican K, Cincik M, Mendilcioglu I, et al. Clinical pregnancy after uterus transplantation. Fertility and sterility 2013; 100(5):1358-63.
• 9. GU. World's first child born after uterus transplantation Sweden: University of Gothenberg; 2014. Erişim tarihi: 20 Nisan 2020. Available from: https://www.gu.se/english/about_the_university/news-calendar/News_detail/world-s-first-child-born-after-uterus-transplantation.cid1239052.
• 10. Cleveland Clinic Performs Nation’s First Uterus Transplant: Cleveland Clinic; 2016. Erişim tarihi: 20 Nisans 2020. Available from: https://health.clevelandclinic.org/cleveland-clinic-is-first-u-s-to-offer-clinical-trial-of-uterus-transplant/.
• 11. Ezjenberg D, Andraus W, Mendes LRBC, Ducatti L, Song A, Tanigawa R, et al. Livebirth after uterus transplantation from a deceased donor in a recipient with uterine infertility. Lancet (London, England) 2018; 392(10165):2697-704.
• 12. Brannstrom M, Dahm-Kahler P. Uterus transplantation and fertility preservation. Best practice & research Clinical obstetrics & gynaecology 2019; 55:109-16.
• 13. Brannstrom M, Bokstrom H, Dahm-Kahler P, Diaz-Garcia C, Ekberg J, Enskog A, et al. One uterus bridging three generations: first live birth after mother-to-daughter uterus transplantation. Fertility and sterility 2016; 106(2):261-6.
• 14. Molne J, Broecker V, Ekberg J, Nilsson O, Dahm-Kahler P, Brannstrom M. Monitoring of Human Uterus Transplantation With Cervical Biopsies: A Provisional Scoring System for Rejection. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2017; 17(6):1628-36.
• 15. Ejzenberg D, Andraus W, Baratelli Carelli Mendes LR, Ducatti L, Song A, Tanigawa R, et al. Livebirth after uterus transplantation from a deceased donor in a recipient with uterine infertility. Lancet (London, England) 2019; 392(10165):2697-704.
• 16. Mazzon I, Corrado G, Masciullo V, Morricone D, Ferrandina G, Scambia G. Conservative surgical management of stage IA endometrial carcinoma for fertility preservation. Fertility and sterility 2010; 93(4):1286-9.
• 17. Park JY, Kim DY, Kim JH, Kim YM, Kim KR, Kim YT, et al. Long-term oncologic outcomes after fertility-sparing management using oral progestin for young women with endometrial cancer (KGOG 2002). European journal of cancer (Oxford, England : 1990) 2013; 49(4):868-74.
• 18. Tock S, Jadoul P, Squifflet JL, Marbaix E, Baurain JF, Luyckx M. Fertility Sparing Treatment in Patients With Early Stage Endometrial Cancer, Using a Combination of Surgery and GnRH Agonist: A Monocentric Retrospective Study and Review of the Literature. Frontiers in medicine 2018; 5:240.
• 19. Bosch FX, Castellsague X, de Sanjose S. HPV and cervical cancer: screening or vaccination? British journal of cancer 2008; 98(1):15-21.
• 20. Kwee A, Bots ML, Visser GH, Bruinse HW. Emergency peripartum hysterectomy: A prospective study in The Netherlands. European journal of obstetrics, gynecology, and reproductive biology 2006; 124(2):187-92.
• 21. Borgfeldt C, Andolf E. Transvaginal ultrasonographic findings in the uterus and the endometrium: low prevalence of leiomyoma in a random sample of women age 25-40 years. Acta obstetricia et gynecologica Scandinavica 2000; 79(3):202-7.
• 22. Donnez J, Dolmans MM. Ovarian cortex transplantation: 60 reported live births brings the success and worldwide expansion of the technique towards routine clinical practice. Journal of assisted reproduction and genetics 2015; 32(8):1167-70.
• 23. Chan YY, Jayaprakasan K, Tan A, Thornton JG, Coomarasamy A, Raine-Fenning NJ. Reproductive outcomes in women with congenital uterine anomalies: a systematic review. Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 2011; 38(4):371-82.
• 24. Grimbizis GF, Camus M, Tarlatzis BC, Bontis JN, Devroey P. Clinical implications of uterine malformations and hysteroscopic treatment results. Hum Reprod Update 2001; 7(2):161-74.
• 25. Fernandez H, Al-Najjar F, Chauveaud-Lambling A, Frydman R, Gervaise A. Fertility after treatment of Asherman's syndrome stage 3 and 4. Journal of minimally invasive gynecology 2006; 13(5):398-402.
• 26. Brannstrom M, Johannesson L, Dahm-Kahler P, Enskog A, Molne J, Kvarnstrom N, et al. First clinical uterus transplantation trial: a six-month report. Fertility and sterility 2014; 101(5):1228-36.
• 27. Wei L, Xue T, Tao KS, Zhang G, Zhao GY, Yu SQ, et al. Modified human uterus transplantation using ovarian veins for venous drainage: the first report of surgically successful robotic-assisted uterus procurement and follow-up for 12 months. Fertility and sterility 2017; 108(2):346-56.e1.
• 28. Johannesson L, Kvarnstrom N, Molne J, Dahm-Kahler P, Enskog A, Diaz-Garcia C, et al. Uterus transplantation trial: 1-year outcome. Fertility and sterility 2015; 103(1):199-204.
• 29. Brucker SY, Brannstrom M, Taran FA, Nadalin S, Konigsrainer A, Rall K, et al. Selecting living donors for uterus transplantation: lessons learned from two transplantations resulting in menstrual functionality and another attempt, aborted after organ retrieval. Archives of gynecology and obstetrics 2018; 297(3):675-84.
• 30. Brannstrom M, Dahm-Kahler P, Kvarnstrom N, Akouri R, Rova K, Olausson M, et al. Live birth after robotic-assisted live donor uterus transplantation. Acta obstetricia et gynecologica Scandinavica 2020.
• 31. Kvarnstrom N, Jarvholm S, Johannesson L, Dahm-Kahler P, Olausson M, Brannstrom M. Live Donors of the Initial Observational Study of Uterus Transplantation-Psychological and Medical Follow-Up Until 1 Year After Surgery in the 9 Cases. Transplantation 2017; 101(3):664-70.
• 32. Mertes H, Van Assche K. UTx With Deceased Donors Also Places Risks and Burdens on Third Parties. The American journal of bioethics : AJOB 2018; 18(7):22-4.
• 33. Chmel R, Pastor Z, Novackova M, Matecha J, Cekal M, Fronek J. Clinical pregnancy after deceased donor uterus transplantation: Lessons learned and future perspectives. The journal of obstetrics and gynaecology research 2019; 45(8):1458-65.
• 34. Chmel R, Novackova M, Janousek L, Matecha J, Pastor Z, Maluskova J, et al. Revaluation and lessons learned from the first 9 cases of a Czech uterus transplantation trial: Four deceased donor and 5 living donor uterus transplantations. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2019; 19(3):855-64.