The use of fetal bovine acellular dermal matrix for management of chronic wounds

Year 2023, Volume: 6 Issue: 4, 713 - 719, 30.07.2023

Tuna Gümüş

https://doi.org/10.32322/jhsm.1261658

Abstract

Aims: In the treatment of chronic wounds, tissue growth must be addressed and optimized. The purpose of this study is to investigate the use of the regenerative medicinal product Fetal Bovine Acellular Dermal Matrix (FBADM) in chronic wounds.
Methods: The patients were chosen sporadically and randomly based on availability to FBADM. Patients were assessed for adequate perfusion, debridement was performed, and wounds were ensured to be free of infection. FBADM was placed in the wound bed covered with a non-adherent contact layer, and a hydrogel sheet was placed to maintain adequate moisture. Offloading or compression was used as clinically indicated. Patients were then followed weekly. Digital photography was used to visually document healing progress.
Results: After 1-3 weeks wounds managed with FBADM had improved characteristics and healthy vascularized tissue that subsequently epithelialized from wound margins or grafted with split thickness skin grafts. Of the 14 wounds we achieved 69% complete healing, 24% non-complete healing after 12 weeks of FBADM application. 7% of the wounds needed skin graft surgery.
Conclusion: We found FBADM to be useful for treatment regimen of diabetic foot and leg ulcers, venous leg ulcers, surgical wounds, and wounds being prepared for skin grafting.

Keywords

Chronic wounds, extracellular matrix, tissue engineering, skin substitutes

Supporting Institution

Wake Forest University School of Medicine

Project Number

00033880

Thanks

Cover letter Dear editor; In this article subjects have been retrospectively evaluated after obtaining IRB approval from Wake Forest School of Medicine ethics committee. Ethics committee approval State IRB number is: IRB00033880. In figures there is no information or evidence to reveal the identities of the participants in the study. The name of the submitted article is “The Use of Fetal Bovine Acellular Dermal Matrix for Management of Chronic Wounds”. This study is conducted in Wake Forest University Wound Care and Hyperbaric Medicine center in USA and article is not published elsewhere and is not being process of being evaluated in another journal at the same time. Conflict of Interest Statement: The authors have no conflicts of interest to declare. Financial Disclosure: The authors declared that this study has received no financial support. Author Contributions: All of the authors declare that they have all participated in the design, execution, and analysis of the paper, and that they have approved the final version. Tuna Gümüş Department of Undersea and Hyperbaric Medicine, University of Health Sciences, Kartal Dr. Lutfi Kirdar City Hospital, Istanbul, Turkey Principal author: Tuna Gümüş Corresponding author: Tuna Gümüş, Department of Undersea and Hyperbaric Medicine, University of Health Sciences, Kartal Dr. Lutfi Kirdar City Hospital, Istanbul, Turkey E mail: [e-mail] Mailing Address: Kartal Dr. Lutfi Kirdar Sehir Hastanesi, 34865, Istanbul / Turkey Mobile: [phone] Fax: [phone]

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