Use of Plant Immunostimulant in Aquaculture

Abstract

The major components of the innate immune system are macrophages, monocytes, granulocytes,
and humoral elements, like lysozyme or complement system which constitute the frst line of defence against
invading pathogens in fsh. Medicinal herbs as immunostimulants of the medicinal herbs increase resistance to
disease by enhancing nonspecifc and specifc defence mechanisms. The active compounds of herbs activate
several components of the immune system, such as phagocytes, natural killer cells, T-lymphocytes, B-lymphocytes,
complement, and lysozyme. In this context plants or their by products are preferred since they contain several
phenolic, polyphenolic, alkaloid, quinine, terpenoid, lectine, and polypeptide compounds many of which have
been shown to be very effective alternatives to antibiotics, chemicals, vaccines, and other synthetic compounds.
Administration of herbal extracts or their products at various concentrations through oral (diet) or injection route
enhance the innate and adaptive immune response of different freshwater and marine fsh and shellfsh against
bacterial, viral, and parasitic diseases. The present review describes the role of medicinal herbs and their products
on innate and adaptive immune response of fsh.

Keywords

• Immunostimulant,aquaculture,plant extract,non-specifc immune system

Su Ürünleri Yetiştiriciliğinde Bitkisel İmmunostimulant Kullanımı

Abstract

Doğal bağışıklık sisteminin önemli komplementleri makrofajlar, monositler, granülositler ve lizozim,
komplement gibi humoral elementler balıklarda patojenlerin istilasına karşı ilk savunma mekanizmasını oluştururlar.
Tıbbi bitkiler bir immunostimulant olarak spesifk ve spesifk olmayan savunma mekanizmasıyla hastalıklara karşı
direnci artırabilmektedirler. Bitkilerin aktif bileşenleri lizozim, komplement, B ve T lenfositleri, doğal öldürücü
hücreler ve fagositoz gibi bağışıklık sisteminin çeşitli komplementlerini etkinleştirebilirler. Bu bağlamda, bitkiler
ve onların yan ürünleri bağışıklık sistemini güçlendirmek için tercih edilebilmektedir. Bitkiler, fenolik, polifenolik,
alkoloid, kinon, terpenoid, lektin ve polipeptit bileşikleri içermektedir. Bu bitkilerin çoğu antibiyotiklere,
kimyasallara, aşılara ve diğer sentetik bileşiklere oldukça etkili alternatifler olarak gösterilmektedirler. Su ürünleri
yetiştiriciliğinde bitkisel ilaçların aynı zamanda antimikrobiyal aktivite gösteren, gelişmeyi kolaylaştıran ve kültür
edilen türlerin olgunlaşmasında etkisi olduğu bunun yanı sıra yoğun yetiştiricilik yapılan çiftliklerde anti-stres
özelliklerinin olduğu herhangi bir çevresel tehlike oluşturmadan kullanıldıkları bilinmektedir. Bitki ekstraktları ya
da onların ürünlerinin çeşitli konsantrasyonlarda oral ya da enjeksiyon yolu ile uygulanması farklı tatlı su ve deniz
balıklarında bakteriyel, viral ve parazitik hastalıklara karşı doğuştan ve adaptif immün cevabı artırmaktadır. Bu
derlemede, balıklarda doğal ve adaptif immün cevap üzerine tıbbi bitkiler ve onların rolü açıklanmaya çalışılacaktır

Keywords

• İmmunostimulant,yetiştiricilik,bitki ekstraktı,spesifk olmayan immunite

References

1. Abdel- Tawwab M, Ahmad HM, Seden MEA, Sakr SFM, 2010. Use of green tea, (Camellia sinensis L.), in practical diet for growth and protection of Nile Tilapia, (Oreochromis niloticus L.), against Aeromonas hydrophila infection. Journal of World Aquaculture Society, 41: 203–213.
2. Acar Ü, Kesbiç OS, Yılmaz S, Gültepe N, Türker A, 2015. Evaluation of the effects of essential oil extracted from sweet orange peel (Citrus sinensis) on growth rate of tilapia (Oreochromis mossambicus) and possible disease resistance against Streptococcus iniae. Aquaculture, 437: 282–286.
3. Agnew W, Barnes AC, 2007. Streptococcus iniae: an aquatic pathogen of global veterinary significance and a challenging candidate for reliable vaccination. Veterinary Microbiology, 122: 1–15.
4. Alderman DJ, Hasting TS, 1998. Antibiotic use in aquaculture: development of antibiotic resistance-potential for consumer health risks. International Journal of Food Science Technology, 33: 139–155.
5. Anderson DP, Moritomo T, Grooth Rd, 1992. Neutrophile, glass adherent, nitroblue tetrazolium assay gives early indication of immunization effectivenecs in rainbow trout. Veterinary Immunol Immunopathology, 30: 419–429.
6. Arda M, Seçer S, Sarıeyüpoğlu M, 2005. Balık Hastalıkları. Medisan Yayınları, Ankara, 61–65 p.
7. Ardo L, Yin G, Xu P, Varadi L, Szigeti G, Jeney Z, Jeney G, 2008. Chinese herbs (Astragalus membranaceus and Lonicera japonica) and boron enhance the non-specific immune response of Nile tilapia (Oreochromis niloticus) and resistance against Aeromonas hydrophila. Aquaculture, 275: 26–33.
8. Aoki T, 1992. Chemotherapy and drug resistance in fish farms in Japan. In: Shariff M, Subasighe RP, Arthur JR, (Eds.). Diseases in Asian Aquaculture Fish Health Section, Asian Fisheries Society, Manila, Philippines, 1: 519–529.

9. Austin B, Austin DA, 2007. Bacterial fish pathogens, Diseases of Farmed and Wild edition. Praxis, Publishing Ltd., Chichester, UK.
10. Awad E, Austin B, 2010. Use of lupin, Lupinus perennis, mango, Mangifera indica, and stinging nettle, Urtica dioica, as feed additives to prevent Aeromonas hydrophila infection in rainbow trout, Oncorhynchus mykiss (Walbaum). Journal of Fish Diseases, 33: 413–420.
11. Awad E, Austin D, Lyndon AR, 2013. Effect of black cumin seed oil (Nigella sativa) and nettle extract (Quercetin) on enhancement of immunity in rainbow trout, Oncorhynchus mykiss (Walbaum), Aquaculture, 388-391: 193–197.
12. Baba E, Acar Ü, Öntaş C, Kesbiç OS, Yılmaz S, 2016. The use of Avena sativa extract against Aeromonas hydrophila and its effect on growth performance, hematological and immunological parameters in common carp (Cyprinus carpio). Italian Journal of Animal Science, 15,2: 325–333. Baba E, Acar Ü, Öntaş C, Kesbiç OS, Yılmaz S, 2016a. Evaluation of Citrus limon peels essential oil on growth performance, immune response of Mozambique tilapia Oreochromis mossambicus challenged with Edwardsiella tarda. Aquaculture, 465: 13–18.
13. Batista S, Ozoria ROA, Kollias S, Dhanasiri AK, Lokesh J, Kiron V, 2016. Changes in intestinal microbiota, immune- and stress-related transcript levels in Senegalese sole (Solea senegalensis) fed plant ingredient diets intercropped with probiotics or immunostimulants. Aquaculture, 458: 149–157.
14. Chen D, Ainsworth AJ, 1992. Glucan administration potentiates immune defense mechanisms of channel catfish, Ictalurus punctatus Rafineque. Journal of Fish Disease, 15: 295–304.
15. Chong YG, Chao TM, 1969. Common Diseases in Marine Finfish. Primary Production Department, Republic of Singapore.
16. Christybapita D, Divyagnaneswari M, Michael DR, 2007. Oral administration of Eclipta alba leaf aqueous extract enhances the non-specific immune responses and disease resistance of Oreochromis mossambicus. Fish Shellfish Immunology, 23: 840–852.
17. Citarasu T, Babu MM, Marian MP, 1998. Application of biomedicinal products for improving marine shrimp larval production. Aqua-Terr. Annual Symposium. School of Biological sciences, MK. University, Madurai, India.
18. Defoirdt T, Boon N, Sorgeloos P, Verstraete W, Bossier P, 2007. Alternatives toantibiotics to control bacterial infections: luminescent vibriosis in aquaculture as an example. Trends Biotechnology, 25: 472–479.
19. Dhar AK., Manna SK., Thomas Allnutt FC, 2014. Viral vaccines for farmed finfish. Virusdisease, 25: 1–17.
20. Divyagnaneswari M, Christybapita D, Dinakaran Michael R, 2007. Enhancement of nonspesific immunity and disease resistance in Oreochromis mossambicus by Solanum trilobatum leaf fractions. Fish Shellfish Immunology, 23:2 49-–259.
21. Ellis AE, 1999. Immunity to bacteria in fish. Fish Shelfish Immunology, 9: 291–308.
22. Fu YW, Hou WY, Yeh ST, Li CH, Chen JC, 2007. The immunostimulatory effects of hot water extract of Gelidium amansii via immersion, injection and dietary administrations on white shrimp Litopenaeus vannamei and its resistance against Vibrio alginolyticus. Fish Shellfish Immunology, 22: 673–685.
23. Gabriel NN, Qiang J, He J, Ma XY, Kpundeh MD, Xu P, 2015. Dietary Aloe vera supplementation on growth performance, some haemato-biochemical parameters and disease resistance against Streptococcus iniae in tilapia (GIFT). Fish Shellfish Immunology, 44:504–514.
24. Galeotti M, 1998. Some aspects of the application of immunostimulants and a critical review of methods for their evaluation. Jornal of Applied Ichthyology, 14: 189–199.
25. Gesamp, 1997. Towards safe and effective use of chemicals in coastal aquaculture. Joint Group of Experts on the Scientific Aspects of Marine Environmental Protection Reports and Studies. FAO, Rome, Italy, 40.
26. Harikrishnan R, Balasundaram C, Heo MS, 2011. Impact of plant products on innate and adaptive immune system of cultured finfish and shellfish. Aquaculture, 317: 1–15.
27. Hashimoto GSO, Neto FM, Ruiz ML, Achille M, Chagas EC, Chaves FCM, Martins ML, 2016. Essential oils of Lippia sidoides and Mentha piperita against monogenean parasites and their influence on the hematology of Nile tilapia. Aquaculture 450: 182–186.
28. Hsieh TJ, Wang JC, Hu CY, Li CT, Kuo CM, Hsieh SL, 2008. Effects of Rutin from Toona sinensis on the immune and physiological responses of white shrimp (Litopenaeus vannamei) under Vibrio alginolyticus challenge. Fish Shellfish Immunology, 25: 581–588.
29. Jeney G, Jeney Z, 2002. Application of immuno stimulants for modulation of the non-specific defense mechanisms in sturgeon hybrid: Acipenser ruthenus x A. baeri. Jornal of Applied Ichthyology, 18: 416– 418.
30. Jian J, Wu Z, 2003. Effects of traditional Chinese medicine on non-spesific immunity and disease resistance of large yellow croaker, Pseudosciaena crocea (Richardson). Aquaculture, 218: 1–9.
31. Jorgensen H, Lunde Robertsen B, 1993. Peritoneal and head-kidney cell response to intraperitoneally injected yeast glucan in Atlantic salmon, Salmo salar L. Journal of Fish Disease, 16: 313–325. Kajita Y, Sakai M, Atsuda S, Kobayashi M, 1990. The immunonodulatory effect of levamisole on rainbow trout Oncorhynchus mykiss. Fish Pathology, 25: 93–98.
32. Kennedy NJ, Spithill TW, Tennent J, Wood PR, Piedrafita D, 2006. DNA vaccines in sheep: CTLA-4 mediated targeting and CpG motifs enhance immunogenicity in a DNA prime/protein boost strategy. Vaccine, 24: 970–979.
33. Kirubakaran CJW, Alexander CP, Dinakaran Michael R, 2010. Enhancement of non-specific immune responses and disease resistance on oral administrati on of Nyctanthes arbortristis seed extract in Oreochromis mossambicus (Peters). Aquaculture, 41: 1630–1639.
34. Kitao T, Yoshida T, 1986. Effect of an immunopotentiator on Aeromonas salmonicida infection in rainbow trout (Salmo gairdneri). Veterinary Immunology Immunopathology, 12: 287–291.
35. Knopf K, Ekanem AP, 2004. Plant extracts for the treatment of Ichthyophthiriasis in fish. Deutscher tropentag, October 5-7, Berlin.
36. Logambal SM, Venkatalakshmi S, Dinakaran MR, 2000. Immunostimulatory effect of Ocimum sanctum Linn. in Oreochromis mossambicus (Peters). Hydrobiologia, 430: 113–120. Magnadottir B, 2006. Innate immunity of fish. Fish Shellfish Immunology, 20: 137–151. Naylor RL, Goldburg RJ, Primavera JH, Kautsky N, Beveridge MC, Clay J, Folke C, Lubchenco J, Money H, Troell M, 2000. Effect of aquaculture on world fish supplies. Nature, 405: 1017–1024.
37. Ngugi CC, Oyoo-Okoth E, Mugo-Bundi J, Orina PS, Chemoiwa EJ, Aloo PA, 2015. Effects of dietary administration of stinging nettle (Urtica dioica) on the growth performance, biochemical, hematological and immunological parameters in juvenile and adult Victoria labeo (Labeo victorianus) challenged with Aeromonas hydrophila. Fish Shellfish Immunology, 44: 530–541.
38. Ngugi CC, Oyoo-Okoth E, Muchiri M, 2016. Effects of dietary levels of essential oil (EO) extract from bitter lemon (Citrus limon) fruit peels on growth, biochemical, haemato-immunological parameters and disease resistance in Juvenile Labeo victorianus fingerlings challenged with Aeromonas hydrophila. Aquaculture Research, 1–13.
39. Nya EJ, Austin B, 2009. Use of garlic, Allium sativum, to control Aeromonas hydrophila infection in rainbow trout, Oncorhynchus mykiss (Walbaum). Journal of Fish Diseases, 32: 963–970.
40. Parisien A, Allain B, Zhang J, Mandeville R, Lan CQ, 2008. Novel alternatives toantibiotics : bacteriophages , bacterial cell wall hydrolases , and antimicrobial peptides. Journal Applied Microbiology, 104: 1–13.
41. Punitha SMJ, Babu MM, Sivaram V, Shankar VS, Dhas SA, Mahesh TC, Immanuel G, Citarasu T, 2008. Immunostimulating influence of herbal bio-medicines on non-specific immunity in Grouper Epinephelus tauvina juvenile against Vibrio harveyi infection. Aquaculture International, 16: 511–523. Raa J, Rorstad G, Engstad RE, Robertson B, 1992. The use of immunostimulants to increase resistance of aquatic organisms to microbial infections. In: Shariff M, Subasinghe RP, Arthur JR, (Eds.). Disease in Asian Aquaculture. Proceedings of the First Symposium on Diseases in Asian Aquaculture. Asian Fisheries Society, Philippines, 1: 39–50.
42. Rattanachaikunsopon P, Phumkhachorn P, 2010. Potential of cinnamon (Cinnamomum verum) oil to control Streptococcus iniae infection in tilapia (Oreochromis niloticus). Fish. Science, 76: 287–293.
43. Robertsen B, 1999. Modulation of the non-specific defence of fish by structurally conserved microbial polymers. Fish Shellfish Immunology, 9: 269–290.
44. Sahu S, Das BK, Mishra BK, Pradhan J, Sarangi N, 2007. Effect of Allium sativum on the immunity and survival of Labeo rohita infected with Aeromonas hydrophila. Journal of Applied Ichthyology, 23: 80–86.
45. Sakai M, 1999. Current research status of fish immunostimulants. Aquaculture, 172: 63–92.
46. Secombes C J, 1996. The Non-specific Immune System: Cellular Defence. In: Iwama G, Nakanishi T, (Eds.). The Fish Immune System. Academic Press, San Diego, California, 63-103.
47. Segvic-Bubic T, Boban J, Grubisic L, Trumbic Z, Radman M, Percic M, Coz-Rakovac R, 2013. Effects of propolis enriched diet on growth performance and plasma biochemical parameters of juvenile European sea bass (Dicentrarchus labrax L.) under acute low-temperature stress. Aquaculture Nutrition, 19:877–885.
48. Sivaram V, Babu MM, Citarasu T, Immanue lG, Murugadass S, Marian MP, 2004.Growth and immune response of juvenile greasy groupers (Epinephelus tauvina ) fed with herbal antibacterial active principle supplemented diets against Vibrio harveyi infections. Aquaculture, 237: 9 –20.
49. Smith P, Hiney MP, Samuelesen OB, 1994. Bacterial resistance to antimicrobialagent used in fish farming: a critical evaluation of method and meaning. Annual Review of Fish Disease, 4: 273–313.
50. Sommerset I, Krossøy B, Biering E, Frost P, 2005. Vaccines for fish in aquaculture. Expert Review Vaccines ,4: 89–101. Trewes- Brown KM, 2000. Applied Fish Pharmacology. Kluwer Academic Publishers, 251-260 p.
51. Yin G, Jeney G, Racz T, Xu P, Jun X, Jeney Z, 2006. Effect of two Chinese herbs (Astragalus radix and Scutellaria radix ) on non-speci fic immune response of tilapia, Oreochromis niloticus. Aquaculture, 253: 39–47.
52. Yoshida T, Sakai M, Kitao T, Khlil SM, Araki S, Saitoh R, Ineno T, Inglis V, 1993. Immunomodulatory effects of the fermented products of chicken egg, EF203, on rainbow trout, Oncorhynchus mykiss. Aquaculture, 109: 207–214.
53. Verma VK, Rani KV, Sehgal N, Prakash O, 2012. Immunostimulatory response induced by supplementation of Ficus benghalensis root powder, in the artificial feed the Indian freshwater murrel, Channa punctatus. Fish Shellfish Immunology, 33: 590–596.
54. Wang JL, Meng X, Lub R, Wu C, Luo YT, Yan X, Li XJ, Kong XH, Nie GX, 2015. Effects of Rehmannia glutinosa on growth performance, immunological parameters and disease resistance to Aeromonas hydrophila in common carp (Cyprinus carpio L.). Aquaculture, 435: 293–300.
55. Watanuki H, Ota Kazuki, Tassakka AR, Kato T, Sakai M, 2006. Immunostimulant effects of dietary Spirulina plantesis on carp, Cyprinus carpio. Aquaculture, 258: 157–163.
56. Won KM, Kim PK, Lee SH, Park SI, 2008. Effect of the residuum extract of Siberian ginseng Eleutherococcus senticosus on non-specific immunity in olive flounder Paralichthys olivaceus. Fish Science 74: 635– 641.
57. Zahran E, Risha E, AbdelHamid F, Mahgoub HA, Ibrahim T, 2014. Effects of dietary Astragalus polysaccharides (APS) on growth performance, immunological parameters, digestive enzymes, and intestinal morphology of Nile tilapia (Oreochromis niloticus). Fish Shellfish Immunology 38: 149–157.
58. Zapata AG, Torroba M, Varas A, Jimenenez E, 1997. Immunity of fish larvae. Developments Biological Standardization, 90: 23–32.
59. ZoyJin, 2003. Application of immunostimulants in larviculture: Feasibility and challenges. Shanghai Fisheries University, 8: 4.