The Effect of Lidocaine, Bupivacaine and Their Mixture on the Life-span of Fruit Flies

Year 2018, , 305 - 313, 30.12.2018

Hakan Aşkın , Ümmügülsüm Tükenmez

https://doi.org/10.21597/jist.433879

Abstract

In this study, the effects of two anesthetic agents with different properties on the life span of

Drosophila melanogaster (fruit-fly) were investigated. There are very few studies on the effects of local anesthetics

in this organism. For this purpose, different doses of the local anesthetic agents (0.0625 %, 0.125 %, 0.25 % and

0.5 %) were applied to third stage larvae. The data obtained from control and test groups showed that there were

changes in the longevity of adults flies which grew from larvae to exposed to these agents. The present results

elucidated that although lidocaine and bupivacaine applications increased life span in parallel with an increase

in dose in female individuals compared to control (p<0.05). The mixture of these two local anesthetics affected

adversely mean life span, maximum mean life span.

Keywords

Bupivacaine, Drosophila melanogaster, lidocaine, the life span

Lidokain, Bupivakain ve Bunların Karışımının Meyve Sineklerinde Ömür Uzunluğu Üzerine Olan Etkisi

Abstract

Bu çalışmada, farklı özelliklere sahip iki anestezik maddenin Drosophila melanogaster’de (meyve sineği)

ömür uzunluğu üzerine etkileri araştırılmıştır. Bu canlıda lokal anestezik maddelerin etkilerine yönelik oldukça az

sayıda çalışma mevcuttur. Bu amaçla üçüncü evre larvalara lokal anestezik maddelerin farklı dozları (% 0.0625,

% 0.125, % 0.25 ve % 0.5) uygulanmıştır. Kontrol ve uygulama gruplarından elde edilen verilerdebu maddelere

maruz kalan larvalardan gelişen ergin sineklerin ömür uzunluğueğişikliklerine neden olduğu belirlenmiştir. Bu

çalışmadan elde edilen sonuçlar lidokain ve bupivakain uygulamalarının dişi bireylerde ömür uzunluğunu kontrole

göre arttırdığını ortaya çıkarmıştır (p<0.05). Bu iki lokal anestezik maddenin karışımı ise ortalama ömür uzunluğu

ve maksimum ortalama ömür uzunluğu üzerine olumlu etki göstermemiştir.

Keywords

Bupivakain, Drosophila melanogaster, lidokain, ömür uzunluğu

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