The Novel Method and One-pot Synthesis of Potential Biological Active Azidosulfonyl Compounds from Alcohols

Abstract

In this study, the one-pot synthesis of azidosulphonyl compounds by a new method was carried out in the presence of chlorosulfonyl isocyanate (CSI) and sodium azide with various alcohols. The acid, base and solvent parameters used to increase the reaction yield were investigated and synthesis of azidosulfonyl compounds was carried out in high yields under optimized reaction conditions. The structure characterization of the synthesized molecules was performed with 1H NMR, 13C NMR, IR and Elemental analysis.

Keywords

• Sulfamoylazide,alcohol,chlorosulfonyl isocyanate,sodium azide

Project Number

BAP-FBA-2018-6964

Tek Kapta Yeni Bir Yöntemle Alkollerden Potansiyel Biyolojik Aktif Azidosülfonil Bileşiklerinin Sentezi

Abstract

Bu çalışmada, çeşitli alkoller ile klorosülfonil izosiyanat (CSI) ve sodyum azid varlığında tek kapta yeni bir yöntemle azidosülfonil bileşiklerinin sentezi gerçekleştirilmiştir. Reaksiyon verimin artırılması için kullanılan asit, baz ve çözücü parametreleri incelenmiş ve optimize reaksiyon şartlarında yüksek verimlerle azidosülfonil bileşiklerinin sentezi gerçekleştirilmiştir. Sentezleri gerçekleştirilen bileşiklerin yapı karakterizasyonları 1H NMR, 13C NMR, IR ve Elementel analiz sonuçları ile yapılmıştır.

Keywords

• Azidosulfonil,alkol,klorosulfonil izosiyanat,sodyum azit

Supporting Institution

Atatürk Üniversitesi

Project Number

BAP-FBA-2018-6964

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