Synthesis of Potentially Biologically Active Some Asymmetric Phenylethyl Urea Derivatives

Abstract

In this study, a number of potentially biologically active asymmetric urea derivatives were synthesized. Accordingly, (R)-(+)-1-phenylethylamine (7) was reacted with 1,1'-carbonyldiimidazole in water and imidazolide intermediates were formed. Then phenethylamine (8a) and substituted phenethylamine derivatives (8b-e) were given. As a result, potentially biologically active novel asymmetric ureas (R)-1-phenethyl-3-(1-phenylethyl) urea (9a) and substituted derivatives (9b-e) were obtained in yields between 60% - 71%.

Keywords

• Asymmetric urea
• 1-phenylethylamine
• phenethylamine
• 1,1’-carbonyldiimidazole

Potansiyel Biyolojik Aktif Bazı Asimetrik Feniletil Üre Türevlerinin Sentezi

Abstract

Bu çalışmada, bir dizi potansiyel biyolojik aktif asimetrik üre türevi sentezlenmiştir. Buna göre (R)-(+)-1-feniletilamin (7) 1,1’-karbonildiimidazol ile su içerisinde reaksiyona sokulmuş ve imidazolid ara ürünleri oluşturulmuştur. Daha sonra üzerine fenetilamin (8a) ve sübstitüe fenetilamin türevleri (8b-e) verildi. Sonuç olarak, potansiyel biyolojik aktif yeni asimetrik üreler (R)-1-fenetil-3- (1-feniletil) üre (9a) ve sübstitüe türevleri (9b-e), % 60 - % 71 arasındaki verimlerle elde edildi.

Keywords

• Asimetrik üre
• 1-feniletilamin
• fenetilamin
• 1,1’-karbonildiimidazol

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