Year 2021, Volume 11 , Issue 2, Pages 1420 - 1429 2021-06-01

Design, Synthesis and Antimicrobial Activities of New Carbon Nanotubes Derivatives
Design, Synthesis and Antimicrobial Activities of New Carbon Nanotubes Derivatives

Aybek YİĞİT [1] , Mehmet Hakkı ALMA [2] , Yüksel AKINAY [3] , Nurettin MENGEŞ [4]


Even though natural products or crops have been more common and popular in the recent, the chemicals without side-effects have been also addressed in various fields of industries due to possibility obtaining the large quantity and more bio-efficacy. In that context, many drugs have been developed for antibacterial activities but the over-uses of those relevant drugs have caused that microorganisms have adapted and evolved resistance against those drugs. Those lead to the researchers to focus on newly synthesized or functionalized molecules. In that context, nanotechnology, especially modified nanocarbon tubes (NCTs), are of the great interest of the various industries. Along with the current study, multi-walled carbon nanotubes (MWCNTs) were functionalized with three steps. Firstly, the carbon nanotube with a carboxylic acid tip on its surface was commercially purchased and then converted into acyl chloride, and later converted into a more reactive group. Then, the nucleophilic amino group such as diethylene triamine is bonded onto the carbon nanotube. Finally, after the carbon nanotube material with amine groups was functionalized with boric acid, carbon nanotube molecules carrying boric acid molecules were synthesized. Following modification and functionalization of MWCNTs, the newly synthesized molecules were characterized using FT-IR, SEM, TEM and XPS. After chemical characterization, the relevant molecules were screened for their anti-bacterial activities in comparison to those of well-known antibiotics. For anti-bacterial assays, molecules were tested against K. pneumoniae, E. coli, P.aeruginosa, S. aureus and B. subtilis. Concerning the findings of the antibacterial assays, concentrations of 40 and 80 μg /mL exhibited a range of activities but in parallel with those of standard antibiotics whereas the lower concentration, viz. 5, 10 and 20 μg / mL did not exhibit any activities. The highest activity was noted for 80 μg / mL, in comparison to those of antibiotics and other concentrations, against B. subtilis, with a 23 mm inhibition zone.
Even though natural products or crops have been more common and popular in the recent, the chemicals without side-effects have been also addressed in various fields of industries due to possibility obtaining the large quantity and more bio-efficacy. In that context, many drugs have been developed for antibacterial activities but the over-uses of those relevant drugs have caused that microorganisms have adapted and evolved resistance against those drugs. Those lead to the researchers to focus on newly synthesized or functionalized molecules. In that context, nanotechnology, especially modified nanocarbon tubes (NCTs), are of the great interest of the various industries. Along with the current study, multi-walled carbon nanotubes (MWCNTs) were functionalized with three steps. Firstly, the carbon nanotube with a carboxylic acid tip on its surface was commercially purchased and then converted into acyl chloride, and later converted into a more reactive group. Then, the nucleophilic amino group such as diethylene triamine is bonded onto the carbon nanotube. Finally, after the carbon nanotube material with amine groups was functionalized with boric acid, carbon nanotube molecules carrying boric acid molecules were synthesized. Following modification and functionalization of MWCNTs, the newly synthesized molecules were characterized using FT-IR, SEM, TEM and XPS. After chemical characterization, the relevant molecules were screened for their anti-bacterial activities in comparison to those of well-known antibiotics. For anti-bacterial assays, molecules were tested against K. pneumoniae, E. coli, P.aeruginosa, S. aureus and B. subtilis. Concerning the findings of the antibacterial assays, concentrations of 40 and 80 μg /mL exhibited a range of activities but in parallel with those of standard antibiotics whereas the lower concentration, viz. 5, 10 and 20 μg / mL did not exhibit any activities. The highest activity was noted for 80 μg / mL, in comparison to those of antibiotics and other concentrations, against B. subtilis, with a 23 mm inhibition zone.
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Primary Language en
Subjects Engineering, Chemical
Published Date Haziran-2021
Journal Section Kimya / Chemistry, Kimya Mühendisliği / Chemical Engineering
Authors

Orcid: 0000-0001-8279-5908
Author: Aybek YİĞİT (Primary Author)
Institution: Igdir University
Country: Turkey


Orcid: 0000-0001-6323-7230
Author: Mehmet Hakkı ALMA
Institution: Igdir University
Country: Turkey


Orcid: 0000-0002-6171-6307
Author: Yüksel AKINAY
Institution: VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ
Country: Turkey


Orcid: 0000-0002-5990-6275
Author: Nurettin MENGEŞ
Institution: VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ
Country: Turkey


Supporting Institution This study was funded by both Van Yüzüncü Yil University (Project Number: 2019-FDK-7816) and Igdir University (Project number: 2019-FBE-A27). Authors thank to The head of the center of Scientific and Application Center in Van Yüzüncü Yil University for spectral support. Also, bioactivity studies was made in Staff Chemical Reagent Company.
Project Number Van Yüzüncü Yil University (Project Number: 2019-FDK-7816) and Igdir University (Project number: 2019-FBE-A27)
Dates

Application Date : January 27, 2021
Acceptance Date : February 4, 2021
Publication Date : June 1, 2021

Bibtex @research article { jist869281, journal = {Journal of the Institute of Science and Technology}, issn = {2146-0574}, eissn = {2536-4618}, address = {}, publisher = {Igdir University}, year = {2021}, volume = {11}, pages = {1420 - 1429}, doi = {10.21597/jist.869281}, title = {Design, Synthesis and Antimicrobial Activities of New Carbon Nanotubes Derivatives}, key = {cite}, author = {Yiğit, Aybek and Alma, Mehmet Hakkı and Akınay, Yüksel and Mengeş, Nurettin} }
APA Yiğit, A , Alma, M , Akınay, Y , Mengeş, N . (2021). Design, Synthesis and Antimicrobial Activities of New Carbon Nanotubes Derivatives . Journal of the Institute of Science and Technology , 11 (2) , 1420-1429 . DOI: 10.21597/jist.869281
MLA Yiğit, A , Alma, M , Akınay, Y , Mengeş, N . "Design, Synthesis and Antimicrobial Activities of New Carbon Nanotubes Derivatives" . Journal of the Institute of Science and Technology 11 (2021 ): 1420-1429 <https://dergipark.org.tr/en/pub/jist/issue/61423/869281>
Chicago Yiğit, A , Alma, M , Akınay, Y , Mengeş, N . "Design, Synthesis and Antimicrobial Activities of New Carbon Nanotubes Derivatives". Journal of the Institute of Science and Technology 11 (2021 ): 1420-1429
RIS TY - JOUR T1 - Design, Synthesis and Antimicrobial Activities of New Carbon Nanotubes Derivatives AU - Aybek Yiğit , Mehmet Hakkı Alma , Yüksel Akınay , Nurettin Mengeş Y1 - 2021 PY - 2021 N1 - doi: 10.21597/jist.869281 DO - 10.21597/jist.869281 T2 - Journal of the Institute of Science and Technology JF - Journal JO - JOR SP - 1420 EP - 1429 VL - 11 IS - 2 SN - 2146-0574-2536-4618 M3 - doi: 10.21597/jist.869281 UR - https://doi.org/10.21597/jist.869281 Y2 - 2021 ER -
EndNote %0 Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi Design, Synthesis and Antimicrobial Activities of New Carbon Nanotubes Derivatives %A Aybek Yiğit , Mehmet Hakkı Alma , Yüksel Akınay , Nurettin Mengeş %T Design, Synthesis and Antimicrobial Activities of New Carbon Nanotubes Derivatives %D 2021 %J Journal of the Institute of Science and Technology %P 2146-0574-2536-4618 %V 11 %N 2 %R doi: 10.21597/jist.869281 %U 10.21597/jist.869281
ISNAD Yiğit, Aybek , Alma, Mehmet Hakkı , Akınay, Yüksel , Mengeş, Nurettin . "Design, Synthesis and Antimicrobial Activities of New Carbon Nanotubes Derivatives". Journal of the Institute of Science and Technology 11 / 2 (June 2021): 1420-1429 . https://doi.org/10.21597/jist.869281
AMA Yiğit A , Alma M , Akınay Y , Mengeş N . Design, Synthesis and Antimicrobial Activities of New Carbon Nanotubes Derivatives. Iğdır Üniv. Fen Bil Enst. Der.. 2021; 11(2): 1420-1429.
Vancouver Yiğit A , Alma M , Akınay Y , Mengeş N . Design, Synthesis and Antimicrobial Activities of New Carbon Nanotubes Derivatives. Journal of the Institute of Science and Technology. 2021; 11(2): 1420-1429.
IEEE A. Yiğit , M. Alma , Y. Akınay and N. Mengeş , "Design, Synthesis and Antimicrobial Activities of New Carbon Nanotubes Derivatives", Journal of the Institute of Science and Technology, vol. 11, no. 2, pp. 1420-1429, Jun. 2021, doi:10.21597/jist.869281