Association of DRD2 Gene C957T Polymorphism with Stuttering in Turkish Population

Year 2022, Volume: 12 Issue: 1, 124 - 132, 01.03.2022

Fikriye Polat , Ayşe Aydin , Burcu Yüksel

https://doi.org/10.21597/jist.946694

Abstract

This study aims to evaluate the association of DRD2 gene C957T polymorphism with stuttering within Turkish children who stutter. The sample of the study included 121 children between the ages of 5-16, 44 children with stuttering and 77 typically developing children. The genomic DNA’s were extracted from the saliva of the individuals. The genotyping of DRD2 C957T was carried out using polymerase chain reaction-restriction fragment length polymorphism. The relationship between genotypes and stuttering was examined through logistic regression analysis. In the study, it was determined that distributions of allele frequencies and the DRD2 gene C957T polymorphism were not significantly different from the control group (OR 0.762; CI 0.458-1.267, p=0.304). The genotype distributions of the DRD2 gene were estimated for CT (OR 1.103; CI 0.443-2.743, p=0.833) and TT (OR 0.868; CI 0.306-2.461; P=0.791). The genotype distributions of DRD2 C957T polymorphism were not statistically significant for additive, dominant, recessive, and codominant models between study groups. As a result, the polymorphic feature of the alleles and genotypes for the DRD2 gene C957T in Turkish children who stutter were analyzed, and it was detected that the differences between CWS and CWNS groups were not significant.Keywords: Stuttering, DRD2, rs6277, Turkish population

Keywords

Stuttering, DRD2, rs6277, Turkish population

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