Auditory, visual and tactile hallucinations in a 16-year-old adolescent with high-dose duloxetine at one time

Year 2020, Volume: 4 Issue: 1, 99 - 101, 02.01.2020

Sefa Cosgun

https://doi.org/10.28982/josam.627206

Abstract

Duloxetine is a dual-acting serotonin-noradrenaline reuptake inhibitor. It has FDA approval for the diagnosis of Major Depressive Disorder (MDD), Generalized Anxiety Disorder (GAD), Diabetic Neuropathic Pain, Fibromyalgia, Chronic Skeletal Muscle Pain in adults, and GAD in children and adolescents. This article presents a 16-year-old female patient referred to the emergency department with hallucinations starting after she took a total of 330 mg/day duloxetine for headaches. It is thought that her experienced hallucinations may be due to increased dopamine, as a result of inhibition of serotonergic system and noradrenaline transport system. It is thought that this article will contribute to the literature in terms of pharmacokinetic and pharmacodynamic effects of duloxetine in children and adolescents.

Keywords

Duloxetine, Hallucination, Adolescent

16 yaşındaki ergende tek seferde yüksek doz duloksetin kullanımı ortaya çıkan işitsel, görsel ve dokunsal halüsinasyonlar

Abstract

Duloksetin dual etkili serotonin-noradrenalin geri alım inhibitörüdür. Erişkinlerde Major Depresif Bozukluk (MDD), Yaygın Anksiyete Bozukluğu (GAD), Diyabetik Nöropatik Ağrı, Fibromiyalji, Kronik İskelet Kas Ağrısı tanılarında, çocuk ve ergenlerde GAD için FDA onayı vardır. Bu yazıda, baş ağrıları olduğu için toplam 330 mg/gün duloksetin içen sonrasında halüsinasyonları başladığı için acil servise başvuran 16 yaşındaki kadın hasta sunulacaktır. Halüsinasyonların serotonerjik sistem ve noradrenalin transport sisteminin inhibisyonu sonucunda dopamin artışına bağlı olabileceği düşünülmektedir. Bu yazı, duloksetinin, çocuk ve ergenlerdeki farmakokinetik ve farmakodinamik etkileri açısından literatüre katkı sağlayacağı düşünülmüştür.

Keywords

Duloksetin, Halüsinasyon, Ergen

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