Comparison of Serum Malondialdehyde and Paraoxonase-1 Levels in Patients with Epilepsy with and without Status Epilepticus

Ahmet Dündar; Demet Arslan; Gülsüm Çelik Uysal; Ahmet Yılmaz

Comparison of Serum Malondialdehyde and Paraoxonase-1 Levels in Patients with Epilepsy with and without Status Epilepticus

Abstract

Aim: The underlying pathophysiological mechanisms in epilepsy are still not fully known. Paraoxonase (PON)-1 activity and malondialdehyde (MDA) levels are biomarkers used in the measurement of oxidative stress. Studies show that oxidative stress has a role in the pathophysiology of epilepsy. The aim of our study is to evaluate serum PON-1 activity and MDA levels in epilepsy patients with and without status epilepticus (SE). Materials and Method: The subjects included in the study were established in two groups. Group I: The patient diagnosed with status epilepticus (n=30), group II: 30 adult patients with epilepsy who were in the outpatient policlinic follow-up and were not in status were included in the study. Serum MDA levels and PON-1 activity were measured by spectrophotometric method in the biochemistry laboratory. Results: Serum MDA levels were found to be 86.8±32.4 nmol/ mL in patients with SE and 65.8±15.7 nmol/mL in patients without SE. Serum PON-1 activity was 180.8±28.3 U/L in patients with SE and 170.2±25.0 U/L in patients without SE. When patients with SE and patients without SE were compared, serum MDA levels were found to be higher than patients without SE and statistically significant (p<0.001). There was no significant difference between the two patient groups in terms of PON-1 activity (p>0.05). Conclusion: The results of our study indicate that the oxidant/ antioxidant balance in the pathogenesis of status epilepticus has deteriorated in favor of oxidative stress and the antioxidant system cannot give an adequate response. Larger research should be conducted to evaluate the use of serum MDA levels as a biomarker.

Keywords

References

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Details

Primary Language

English

Subjects

Clinical Sciences

Journal Section

Research Article

Authors

Ahmet Dündar This is me
Türkiye

Demet Arslan This is me
Türkiye

Gülsüm Çelik Uysal This is me
Türkiye

Ahmet Yılmaz This is me
Türkiye

Publication Date

April 26, 2023

Submission Date

March 11, 2022

Acceptance Date

January 9, 2023

Published in Issue

Year 2023 Volume: 13 Number: 1

IZ

https://izlik.org/JA86CY77PM

Cite

RIS / Bibtex

APA

Dündar, A., Arslan, D., Çelik Uysal, G., & Yılmaz, A. (2023). Comparison of Serum Malondialdehyde and Paraoxonase-1 Levels in Patients with Epilepsy with and without Status Epilepticus. Kafkas Journal of Medical Sciences, 13(1), 18-23. https://izlik.org/JA86CY77PM

AMA

1.Dündar A, Arslan D, Çelik Uysal G, Yılmaz A. Comparison of Serum Malondialdehyde and Paraoxonase-1 Levels in Patients with Epilepsy with and without Status Epilepticus. Kafkas Journal of Medical Sciences. 2023;13(1):18-23. https://izlik.org/JA86CY77PM

Chicago

Dündar, Ahmet, Demet Arslan, Gülsüm Çelik Uysal, and Ahmet Yılmaz. 2023. “Comparison of Serum Malondialdehyde and Paraoxonase-1 Levels in Patients With Epilepsy With and Without Status Epilepticus”. Kafkas Journal of Medical Sciences 13 (1): 18-23. https://izlik.org/JA86CY77PM.

EndNote

Dündar A, Arslan D, Çelik Uysal G, Yılmaz A (April 1, 2023) Comparison of Serum Malondialdehyde and Paraoxonase-1 Levels in Patients with Epilepsy with and without Status Epilepticus. Kafkas Journal of Medical Sciences 13 1 18–23.

IEEE

[1]A. Dündar, D. Arslan, G. Çelik Uysal, and A. Yılmaz, “Comparison of Serum Malondialdehyde and Paraoxonase-1 Levels in Patients with Epilepsy with and without Status Epilepticus”, Kafkas Journal of Medical Sciences, vol. 13, no. 1, pp. 18–23, Apr. 2023, [Online]. Available: https://izlik.org/JA86CY77PM

ISNAD

Dündar, Ahmet - Arslan, Demet - Çelik Uysal, Gülsüm - Yılmaz, Ahmet. “Comparison of Serum Malondialdehyde and Paraoxonase-1 Levels in Patients With Epilepsy With and Without Status Epilepticus”. Kafkas Journal of Medical Sciences 13/1 (April 1, 2023): 18-23. https://izlik.org/JA86CY77PM.

JAMA

1.Dündar A, Arslan D, Çelik Uysal G, Yılmaz A. Comparison of Serum Malondialdehyde and Paraoxonase-1 Levels in Patients with Epilepsy with and without Status Epilepticus. Kafkas Journal of Medical Sciences. 2023;13:18–23.

MLA

Dündar, Ahmet, et al. “Comparison of Serum Malondialdehyde and Paraoxonase-1 Levels in Patients With Epilepsy With and Without Status Epilepticus”. Kafkas Journal of Medical Sciences, vol. 13, no. 1, Apr. 2023, pp. 18-23, https://izlik.org/JA86CY77PM.

Vancouver

1.Ahmet Dündar, Demet Arslan, Gülsüm Çelik Uysal, Ahmet Yılmaz. Comparison of Serum Malondialdehyde and Paraoxonase-1 Levels in Patients with Epilepsy with and without Status Epilepticus. Kafkas Journal of Medical Sciences [Internet]. 2023 Apr. 1;13(1):18-23. Available from: https://izlik.org/JA86CY77PM